sn2 reactions
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2021 ◽  
Author(s):  
Honggen Wang ◽  
Fang-Hai Tu ◽  
Zhan Li ◽  
Shuang Yang ◽  
Yin Li ◽  
...  

The gem-difluoroalkanes widely exist in pharmaceuticals, agrochemicals and materials. Reported herein is a facile synthesis of tosyloxylated gem-difluoroalkanes via an oxidative fluorination of readily available vinyl sulfonates. An intriguing [2,3]-sulfonyloxy migration is involved as a key step. The OTs group in the product enables a divergent and modular synthesis of a wide variety of functionalized gem-difluoroalkanes via reliable SN2 reactions. Notable features of this protocol include mild reaction conditions, high efficiency and remarkably good functional-group tolerance.


2021 ◽  
Author(s):  
Trevor A. Hamlin ◽  
Thomas Hansen ◽  
Pascal Vermeeren ◽  
F. Matthias Bickelhaupt
Keyword(s):  

Author(s):  
Trevor A. Hamlin ◽  
Thomas Hansen ◽  
Pascal Vermeeren ◽  
F. Matthias Bickelhaupt
Keyword(s):  

Author(s):  
Malte Fugel ◽  
Anneke Dittmer ◽  
Florian Kleemiss ◽  
Simon Grabowsky

2021 ◽  
Author(s):  
Clàudia Climent ◽  
Johannes Feist

<div> <div> <div> <p> </p><div> <div> <div> <p>In September 2020, we became aware that a comment (A. Thomas, L. Lethuillier-Karl, J. Moran and T. Ebbesen, 2020, DOI:10.26434/chemrxiv.12982358.v1.) on our recent paper (C. Climent and J. Feist, Phys. Chem. Chem. Phys., 2020, 22, 23545) had been posted to ChemRxiv. Since our attempts in October 2020 to reach out to the authors to discuss the points they raised did not receive a response as of April 2021, and the comment was not submitted as a formal comment to the original journal either, we here provide a brief reply based on the results that were already reported in our original manuscript. Most importantly, we show that we did not “presumably overlook” any data in the supplementary material of their original article, but that our results are actually fully consistent with those data. </p> </div> </div> </div> </div> </div> </div>


2021 ◽  
Author(s):  
Clàudia Climent ◽  
Johannes Feist

<div> <div> <div> <p> </p><div> <div> <div> <p>In September 2020, we became aware that a comment (A. Thomas, L. Lethuillier-Karl, J. Moran and T. Ebbesen, 2020, DOI:10.26434/chemrxiv.12982358.v1.) on our recent paper (C. Climent and J. Feist, Phys. Chem. Chem. Phys., 2020, 22, 23545) had been posted to ChemRxiv. Since our attempts in October 2020 to reach out to the authors to discuss the points they raised did not receive a response as of April 2021, and the comment was not submitted as a formal comment to the original journal either, we here provide a brief reply based on the results that were already reported in our original manuscript. Most importantly, we show that we did not “presumably overlook” any data in the supplementary material of their original article, but that our results are actually fully consistent with those data. </p> </div> </div> </div> </div> </div> </div>


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