This introduction discusses the development of Quine’s system over time and the centrality of structure to it. It explains the contributions made in this volume to our understanding of Quine’s thought on structure and ontology, especially with respect to philosophical logic, philosophy of language, history of philosophy, mathematics, philosophy of time, and set theory. Chapters by Michael Resnik, Frederique Janssen-Lauret and Fraser MacBride, John Collins, Jaroslav Peregrin, and Paul Gregory explore whether Quine’s structuralism is epistemological, language-based, or ontological. Greg Frost-Arnold, Robert Sinclair, and Gary Kemp and Andrew Lugg explore Quine’s views on structure from a historical point of view. Nathan Salmón, Gila Sher, Marianna Antonutti Marfori, and Natalja Deng consider Quine’s views on the structure of logic, language, and theories in relation to contemporary philosophy, specifically ontology, the philosophy of logic and mathematics, philosophy of set theory, and philosophy of time.