Probing Inclusion Complexes of Pentoxifylline and Pralidoxim inside Cyclic Oligosaccharides by Physicochemical Methodologies

Structurally different Molecules namely Pentoxifylline and Pralidoxim were chosen along with α-cyclodextrin and β-cyclodextrin to study host-guest inclusion phenomena. The formations of host guest inclusion complexes were confirmed by studying 1H-NMR spectra, FT-IR spectra, apparent molar volume and viscosity co-efficient. The stabilities of inclusion complexes were compared calculating the binding constant from UV-VIS spectroscopic study. The 1:1 stoichiometry of the inclusion complexes were also determined by analysing the Jobs plot and surface tension data. The values for Gibbs’ free energy were found negative for both the processes. Based on all the above experiments the inclusion processes were found feasible for both the compounds. These types of inclusion complexes are of high interest in the field of research and industry as these are used as drug delivery systems.

An air-supported liquid crystal system for real-time reporting of host–guest inclusion events

A new method for reporting host–guest inclusion phenomena using an air-supported liquid crystal system based on cyclodextrins was developed.

Inclusion Phenomena between theβ-Cyclodextrin Chiral Selector and Trp-D,L, and Its Use on the Assembly of Solid Membranes

The application ofβ-cyclodextrin (β-CD) and the chiral ionic liquids formed fromβ-cyclodextrin mono-6-deoxy-6-(3-methylimidazolium)-β-cyclodextrin tosylate (β-CD-IL) as chiral selectors is described. The inclusion phenomena between theβ-cyclodextrin chiral selectors and D,L-tryptophan (D,L-Trp) was studied. The inclusion compounds were prepared by grinding, and their properties analyzed by X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FT-IR), and nuclear magnetic resonance (NMR). The separation factor betweenβ-CD andβ-CD-IL with D,L-Trp was studied by the saturated solution method. This indicated a different binding capacity ofβ-CD andβ-CD-IL to the two enantiomers. This result shows that the chiral ionic liquids have a higher separation factor because of their high solubility. Theβ-cyclodextrin chiral ionic liquids and CS were cross-linked and immobilized on an N6 membrane to form composite membranes. Adsorption experiments and permeation experiments were carried out. 105.43 mg D,L-Trp/g membrane was obtained.