Carcinoma della prostata: prostatectomia radicale nei pazienti over 70

Prostate cancer is one of the most common male cancers in industrialized countries and it occurs mainly in men older than 50 years. In light of a rapidly ageing population it seems certain tha increasingly many septuagenarians with significant life-expectancy will present with prostate cancer to urologist. However currently there is a lack of consensus on prostate cancer and its treatment in the cohort of men ≥ 70 years of age. Although elderly men are often recommended a watchfull waiting option based on lower life expentancy and potentially slow disease progression, recent evidences indicate suggest a potential benefit of radical prostatectomy in selected older patients. The aim of this review is to illustrate the evidences demonstrating the efficacy and safety and of radical prostatectomy in patients over 70. Also, are presented the results of a small Italian study on patients aged ≥ 70 years with clinically localized prostate cancer undergoing radical prostatectomy. The results show that radical prostatectomy is a safe and effective option in elderly patients, with low incidence of complications and recovery of continence in about two-thirds of patients.

Carcinoma della prostata: prostatectomia radicale nei pazienti over 70

Prostate cancer is one of the most common male cancers in industrialized countries and it occurs mainly in men older than 50 years. In light of a rapidly ageing population it seems certain tha increasingly many septuagenarians with significant life-expectancy will present with prostate cancer to urologist. However currently there is a lack of consensus on prostate cancer and its treatment in the cohort of men ≥ 70 years of age. Although elderly men are often recommended a watchfull waiting option based on lower life expentancy and potentially slow disease progression, recent evidences indicate suggest a potential benefit of radical prostatectomy in selected older patients. The aim of this review is to illustrate the evidences demonstrating the efficacy and safety and of radical prostatectomy in patients over 70. Also, are presented the results of a small Italian study on patients aged ≥ 70 years with clinically localized prostate cancer undergoing radical prostatectomy. The results show that radical prostatectomy is a safe and effective option in elderly patients, with low incidence of complications and recovery of continence in about two-thirds of patients.

Valore prognostico della ploidia cellulare nel carcinoma della prostata

Clinical and pathological staging and histological grading do not always have sufficient value to predict the behaviour of prostatic carcinoma after prostatectomy. Many studies have suggested that DNA ploidy can provide additional prognostic information. DNA ploidy was determined by flow cytometry on paraffin-embedded tissue from 44 radical prostatectomies for carcinoma. The percentage of aneuploid tumours was higher among poorly differentiated neoplasms, in advanced stage and in cases with progression of disease, also considering the same stage and grade. DNA ploidy can represent a significant prognostic parameter in the post-operative evaluation of patients with prostatic carcinoma.