Being Agreeable

This chapter focuses on the social practice of being agreeable. The practice consists in the appropriate acknowledgment of other people in social gatherings, appropriate responsiveness to their needs and claims, and an appropriately cheerful disposition. The social practice of presenting oneself as open to engagement with other people and willing to respond to their claims is important to the normative space that constitutes a good moral neighborhood. In that space, people are able to carry out their projects and live up to their various commitments. The practice of agreeableness reinforces our willingness to help each other with those projects and enables us to count on others in return. Like self-deprecation, the social practice of agreeableness has the potential to undermine moral neighborhoods, particularly when it is used to reinforce troubling social norms about gender and race.

Multiantibody Strategies for HIV

Vaccination strategies depend entirely on the appropriate responsiveness of our immune system against particular antigens. For this active immunization to be truly effective, neutralizing antibodies (nAbs) need to efficiently counter the infectivity or propagation of the pathogen. Some viruses, including HIV, are able to take advantage of this immune response in order to evade nAbs. This review focuses on viral immune evasion strategies that result directly from a robust immune response to infection or vaccination. A rationale for multi-Ab therapy to circumvent this phenomenon is discussed. Progress in the formulation, production, and regulatory approval of monoclonal antibodies (mAbs) is presented.