Effect of 2,6-diisopropylphenol and 1,1,1,3,3,3-hexafluoro-2-(fluoromethoxy) propane as Anesthetic

Sevoflurane (2,2,2-trifluoro-1-[trifluoromethyl]ethyl fluoromethyl ether or C4H3F7O), with a molar mass 200.055 g/mol, also called fluoromethyl, is a highly fluorinated methyl isopropyl ether with general anesthetic property, available for clinical practice for about 30 years. Sevoflurane is a sweet-smelling, non-flammable and it is used for induction and maintenance of general anesthesia. Together with desflurane, it is replacing isoflurane and halothane in modern anesthesiology. Propofol (2,6-diisopropylphenol or C12H18O), with a molar mass 178.271g/mol is an alkylphenol derivative formulated for induction and maintenance (in some cases) of general anesthesia, sedation and hypnosis and acting as an intravenous anaesthetic drug, having largely replaced sodium thiopental because recovery from propofol is more rapid and clear.

Antagonism of calcium-induced contraction in potassium-depolarized rabbit detrusor muscle strips by dicyclomine hydrochloride and rodverine

The musculotropic action of dicyclomine hydrochloride in bladder muscle has been attributed to its local anesthetic activity. In this study rabbit detrusor strips were depleted of calcium by incubation in a Ca2+ -free solution containing ethylene glycol bis(β-aminoethyl ether)-N,N′-tetraacetic acid (EGTA). Contractions elicited by replacement of Ca2− during depolarization with 80 mM K+ were only slightly affected by atropine or scopolamine but were antagonized in a noncompetitive manner by dicyclomine and rociverine (pD2′ = 4.89 and 4.61, respectively). These contractions were also blocked with greater potency by nifedipine (pD2′ = 8.50) and with lesser potency by lidocaine (pD2′ = 2.52). Procaine was ineffective up to 1 mM. Comparison of the antagonism produced by dicyclomine and rociverine with that produced by nifedipine or lidocaine did not help to define the mechanism of the musculotropic drugs. However, as rociverine is not a local anesthetic and procaine was not effective, it appears that the "local anesthetic" property is not sufficient to explain the action of these musculotropic drugs.

THE EFFECT OF BARBITURATES AND OTHER SUBSTANCES ON MOTION SICKNESS IN DOGS

A large series of barbiturates and other substances have been tested for their ability to prevent motion sickness in dogs. Many compounds were found to possess this activity, which was not related to the anesthetic property of the compound. A number of barbiturates were found to be considerably more active than V-12, which was used as a standard. Pyridoxine, hyoscine, and streptomycin were inactive in the tests described. Bulbocapnine possessed half the potency of V-12 and showed an additive effect when the two substances were given together.

About the action of peronin by eye

Abstracts. Eye diseases.L. V. Smirnov. About the action of peronin by eye. Diss. S.-PB. 1900.In 1899, Bufalini offered in eye practice the local anaestheticum peronin, chemical nature chlorine hydrate benzene of the morphine ether, which belongs to the derivatives of morphine. The author investigated the proposed remedy, having tested its anesthetic property, its influence on the pupil, accommodation, tension, diffusion and on the corneal epithelium.