On a routine examination of 168 muscle biopsies by transmission electron microscopy, we observed various structures, like filamentous bodies in 49 cases (29%), tubular aggregates in 22 (13%), paracrystalline inclusions in 15 (9%), honeycomb arrays in 11 (6.5%), concentric laminated bodies in 10 (6%), fingerprint bodies in 6 (3.8%), and fibrous nuclear inclusions in 3 (1.8%), for a total of 116/168 or a 70% occurrence. In order to evaluate the significance and occurrence of these structures in muscle biopsies, we correlated the clinical features, light microscopic and histochemical findings on these patients.168 muscle biopsies were studied. The muscle biopsy was obtained by using the conventional muscle clamp in all the cases. After obtaining the muscle biopsy in each case, about 1/3 of the length was frozen in liquid nitrogen at -170 degrees F to be used for histochemistry. The second 1/3 was fixed in formalin for paraffin section, and the remaining 1/3 was minced in small pieces and fixed in 2.5% glutaraldehyde for electron microscopy study.