Anti-arrhytmic Activity of N-Acetic Derivative of l-Glutamic Acid in Case of Acute Myo-cardium Ischemia and Streptozotocin-Induced Diabetes Mellitus

Anti-arrhythmic activity of liquid dosage forms of N-acetyl-L-glutamic acid internally introduced was studied in experiments on animals with streptozotocin diabetes mellitus and acute myocardial ischemia. The prescription of this compound to rats with diabetes in the dose of 125 mg/kg / day for 14 days and it use prevents early occlusion and reperfusion arrhythmias, resulting in a statistically significant reduction in the development of ventricular arrhythmias and ventricular fibrillation. The studies in dogs with diabetes mellitus proved that prophylactic introduction N-acetyl-L-glutamic acid at a dose of 60 mg/kg is accompanied by full and partial suppression of ectopic activity on the second day after the formation of acute myocardial infarction, reduction of metabolic acidosis and increased oxygen consumption in the ischemic zone of alteration. The results suggest that the course introduction domestic derivative of L-glutamic acid in animals of different species prevents the formation of ischemia-mediated cardiovascular events and can be as potential anti-arrhythmic agent. The work is supported by the project (project code-2859) performed by Mordovia State N.P. Ogarev University and RFBR grant 14-04-31104.