Early conflicts between the Calvinists and Pierre Caroli, Antoine Marcourt, and their allies led to the development of local bastions of sustained opposition to Calvin and his disciples in francophone Switzerland, chiefly in the areas around Yverdon, Morges, and the Pays de Gex. Pierre Caroli fled to Switzerland after the Affair of the Placards. There, he became friends with Jean Lecomte, Thomas Malingre, and Antoine Marcourt. In the first major split among evangelicals in Switzerland, however, he became an enemy of Calvin, Farel, and Viret in a quarrel over prayers for the dead and the trinity. In 1538, the appointment of Marcourt and Jean Morand to replace the exiled Calvin and Farel in Geneva exacerbated the division between the two sides. By the mid-1540s, opposition to the Calvinists was well entrenched in the areas where these individual opponents were active.