Coumatetralyl (COM) is an anticoagulant rodenticide absorbed quickly after oral dosing. It causes rodent’s death due to internal or external bleeding after complete depletion of plasma vitamin K-dependent coagulation factors. The present study aimed was to shed light on metabolic alterations as the potential hepato- and nephrotoxicity caused by ¼ LD50 COM in Rattus rattus, Arvicanthis niloticus, and Geribellus geribellus wild rat species. Elevation in plasma alanine aminotransferase (ALT), aspartate aminotransferase (AST), albumin, total free amino acids, and erythrocyte lysate glucose-6-phosphate dehydrogenase levels were observed in COM fed rats. Furthermore, plasma creatinine and urea and free hemoglobin levels increased following COM exposure in the challenged rats compared with that in the control ones. It was concluded that ¼ LD50 COM induced hepato- and nephron-toxicity in the fighting rodents.
Quality assessment of ready-to-eat foods served in some cafeterias of Makkah City, Saudi Arabia