Comparative acute toxicity of four drugs. A study of neomycin, gentamicin, kanamycin, and dihydrostreptomycin

1967 ◽  
Vol 119 (5) ◽  
pp. 493-502 ◽  
Author(s):  
N. M. Nord
Keyword(s):  
Acute Toxicity ◽  
Comparative Acute Toxicity

Comparative Acute Toxicity of Shale and Petroleum Derived Distillates

1985 ◽  
Vol 5 (6) ◽  
pp. 1005-1016 ◽  
Author(s):  
Charles R. Clark ◽  
Paul W. Ferguson ◽  
Mark A. Katchen ◽  
Michael W. Dennis ◽  
Douglas K. Craig
Keyword(s):  
Acute Toxicity ◽  
Skin Irritation ◽  
Inhalation Exposure ◽  
Petroleum Products ◽  
Health Impacts ◽  
Shale Oil ◽  
Potential Health ◽  
Low Toxicity ◽  
Distillate Fractions ◽  
Comparative Acute Toxicity

In anticipation of the commercialization of its shale oil retorting and upgrading process, Unocal Corp. conducted a testing program aimed at better defining potential health impacts of a shale industry. Acute toxicity studies using rats and rabbits compared the effects of naphtha, Jet-A, JP-4, diesel and “residual” distillate fractions of both petroleum derived crude oils and hydrotreated shale oil. No differences in the acute oral (> 5 g/kg LD50) and dermal (> 2 g/kg LD50) toxicities were noted between the shale and petroleum derived distillates and none of the samples were more than mildly irritating to the eyes. Shale and petroleum products caused similar degrees of mild to moderate skin irritation. None of the materials produced sensitization reactions. The LC50 after acute inhalation exposure to Jet-A, shale naphtha, (> 5 mg/L) and JP-4 distillate fractions of petroleum and shale oils was greater than 5 mg/L. The LC50 of petroleum naphtha (> 4.8 mg/L) and raw shale oil (> 3.95 mg/L) also indicated low toxicity. Results demonstrate that shale oil products are of low acute toxicity, mild to moderately irritating and similar to their petroleum counterparts. The results further demonstrate that hydrotreatment reduces the irritancy of raw shale oil.

Caulerpin, Caulerpicin, Caulerpa scalpelliformis: Comparative Acute Toxicity Study

1984 ◽  
Vol 27 (12) ◽  
Author(s):  
J. P. Vidal ◽  
D. Laurent ◽  
S. A. Kabore ◽  
E. Rechencq ◽  
M. Boucard ◽  
...  
Keyword(s):  
Acute Toxicity ◽  
Toxicity Study ◽  
Acute Toxicity Study ◽  
Comparative Acute Toxicity
Sign in / Sign up

Export Citation Format

Share Document