His bundle recording in acquired conduction disease

1975 ◽  
Vol 135 (3) ◽  
pp. 397-403 ◽  
Author(s):  
R. C. Dhingra
1981 ◽  
Vol 59 (11) ◽  
pp. 1192-1195
Author(s):  
Peter E. Dresel ◽  
Keith D. Cameron

The effects of disopyramide (DP) and a new antiarrhythmic agent, disobutamide (DB) on cardiac conduction were studied using His bundle recording from modified rabbit Langendorff preparations electrically driven at 3 and 4 Hz. Both disopyramide (4–16 μg/mL) and disobutamide (1–30 μg/ml) slowed conduction throughout the atrioventricular conduction system, i.e., SA, AH, and HV intervals were increased in a dose-related manner. Conversion of the conduction time changes to percent changes indicates that disobutamide has a relatively equal effect on each part of the system whereas disopyramide exhibited significantly less effect on AV nodal conduction. Slowing of conduction in the AV node by DP was clearly related to rate. Changes in SA and HV intervals were rate related to a lesser degree. No such rate-related effect was evident with disobutamide. Block of atrial conduction occurred in two out of six hearts when the rate was increased at 8 μg/mL of DP and in three additional hearts at 16 μg/mL. This was interpreted to indicate a change in atrial excitability such that 2 × threshold currents no longer excited the tissues. This was not observed at any concentration of DB.


2016 ◽  
Vol 8 (1) ◽  
pp. 51
Author(s):  
Nicolas Badenco ◽  
Caroline Nguyen ◽  
Robert Frank ◽  
G. Duthoit ◽  
Carole Maupain ◽  
...  

1978 ◽  
pp. 33-45 ◽  
Author(s):  
Ludger Seipel ◽  
Gunter Breithardt ◽  
Horst Kuhn

1983 ◽  
Vol 6 (5) ◽  
pp. 1057-1061 ◽  
Author(s):  
PEDRO BRUGADA ◽  
ALPHONS R V. WYLICK ◽  
HOSHIAR ABDOLLAH ◽  
JAN STAPPERS ◽  
HEIN J.J. WELLENS

1988 ◽  
Vol 11 (2) ◽  
pp. 220-224 ◽  
Author(s):  
JUAN CINCA ◽  
ANGEL MOYA ◽  
ALFREDO BARDAJÍ ◽  
JAIME FIGUERAS ◽  
JORGE RIUS

1972 ◽  
Vol 81 (6) ◽  
pp. 1167-1170 ◽  
Author(s):  
Jill H. Morriss ◽  
George S. Eugster ◽  
James J. Nora ◽  
Ray Pryor

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