OCULAR DISTURBANCES ASSOCIATED WITH EXPERIMENTAL LESIONS OF THE MESENCEPHALIC CENTRAL GRAY MATTER

1937 ◽  
Vol 18 (4) ◽  
pp. 614 ◽  
Author(s):  
ERNEST A. SPIEGEL
Neurosurgery ◽  
1979 ◽  
Vol 4 (2) ◽  
pp. 152-156 ◽  
Author(s):  
J. E. Smith ◽  
P. V. Hall ◽  
M. R. Galvin ◽  
A. R. Jones ◽  
R. L. Campbell

Abstract Twelve female mongrel dogs were made paraplegic by midthoracic spinal cord transection. Beginning at 9 weeks posttransection, either glycine (50 mg/kg) or saline was injected intramuscularly each day and the signs of spinal spasticity were assessed clinically. After treating the dogs for 3 weeks, we removed the lumbar enlargement of each dog and microdissected it into gray and white areas which we assayed for glycine, glutamate, and aspartate content. Some of the clinical signs of spasticity improved in the animals injected with glycine compared to the saline-injected controls. The content of glycine was significantly elevated in the central gray matter and ventral medial white matter of the glycinetreated dogs. The levels of glutamate were also significantly elevated in the central, lateral ventral, and medial ventral gray matter and in the dorsal lateral and ventral medial white matter of the glycine-treated dogs. The possible role of these segmental putative neurotransmitters in spinal spasticity is discussed.


1987 ◽  
Vol 104 (5) ◽  
pp. 1509-1512 ◽  
Author(s):  
Yu. D. Ignatov ◽  
Yu. N. Vasil'ev ◽  
M. S. Butkhuzi ◽  
Z. A. Sakvarelidze ◽  
E. V. Abzianidze ◽  
...  

1971 ◽  
Vol 35 (3) ◽  
pp. 272-276 ◽  
Author(s):  
Franklin C. Wagner ◽  
George J. Dohrmann ◽  
Paul C. Bucy

✓ The microscopic appearance of the primate spinal cord within a 4-hour interval following the delivery of a direct force sufficient to produce a transitory paraplegia was investigated by light microscopy. The resulting hemorrhagic lesion involved primarily the central gray matter and was attributed to the direct effect of the trauma on the vessels in the gray matter with a consequent impairment of blood supply to the injured area. Chromatolysis, vacuolation, and alterations in cytoplasmic density and stainability were observed within the neurons. The edematous changes in the white matter, which were more marked in the internal layers relative to the external layers, appeared minimal and explain in part why the paraplegia was transient.


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