Development of Occlusive Arterial Disease in Lower Limbs

1971 ◽  
Vol 103 (5) ◽  
pp. 545 ◽  
Author(s):  
Francois Kuthan
Keyword(s):  
Arterial Disease ◽  
Lower Limbs ◽  
Occlusive Arterial Disease

Cyclic Nucleotides And PlateLet-Leukocyte Aggregates In Patients With Occlusive Arterial Disease

1981 ◽  
Author(s):  
B Kiersnowska-Rogowska ◽  
M Bielawiec ◽  
F Rogowski ◽  
A Bodzenta ◽  
J Giedrojć
Keyword(s):  
Cyclic Amp ◽  
Cyclic Gmp ◽  
Cyclic Nucleotides ◽  
Arterial Disease ◽  
Lower Limbs ◽  
Control Group ◽  
Occlusive Arterial Disease ◽  
Hospital Deaths ◽  
And Function

The aim of the work was to study plasma cyclic nucleotides level /cyclic-AMP and cyclic-GMP/ and platelet-leukocyte aggregates in patients with obliterative arteriosclerosis of the lower limbs. The following parameters were investigated: cyclic-AMP and GMP radioimmunochemically by the use of a cyclic-AMP and cyclic-GMP assay kit, platelet leukocyte aggregates by the method of Silbergleit in our modification.The remainder were hospital deaths, five within the first 48 hours, 8 between 2-14 days, and 4 between 14 and 94 days. Five cases showed subendocardial infarction (SI). Four of these occuring out of hospital. The remaining 18 cases were transmural infarctions (TI). Sixteen of 17 hospital deaths exhibited TI.Significant decrease in cyclic-AMP level was found in arteriosclerotic patients in comparison to the control group. No significant changes in cyclic-GMP level were observed. The number of platelet-leukocyte aggregates was significantly higher in these patients.The influence of Hydroxy-ethyl-rutosides /HR/ on investigated parameters was also studie.The significant decrease in the level of cyclic-GMP in plasma was observed in patients after intravenously injection of 1000 mg of HR whereas no changes were found in cyclic-AMP level. The significant decrease in the number of platelet-leukocytes aggregates in the blood obtained after HR injection was also observed.Our results have shown the disturbances of plasma cyclic nucleotides balance and function of platelets and leukocyte in arteriosclerotic patients. This study also suggests that HR may be a modulating agent of these parameters.

scholarly journals The Platelet-Leukocyte Aggregates in Occlusive Arterial Disease and the Effect of Hydroxyethylrutosides

1977 ◽  
Author(s):  
M. Bielawiec ◽  
B. Kiersnowska-Rogowska ◽  
H. Łukjan
Keyword(s):  
Healthy Subjects ◽  
Arterial Disease ◽  
Diagnostic Value ◽  
Lower Limbs ◽  
Control Group ◽  
Arteriosclerosis Obliterans ◽  
Occlusive Arterial Disease ◽  
Nicotinic Acid Derivatives ◽  
The Mean

The diagnostic value and the effect of the therapy on the number and kind of platelet-leukocyte aggregates in patients with arteriosclerosis obliterans of the lower limbs were investigated. The modified Silbergleit’s method was used. 8 types of aggregates were found. The mean number of aggregates in 20 healthy subjects was 8.2, in 52 patients suffering from obliterative arteriosclerosis of the lower limbs this number was significantly higher, that is 63.9. In healthy subjects most of the aggregates were type 1 to 4 whereas in the patients types 3 and 5 were most frequently found. 30 patients were treated for 3 weeks with hydroxyethylrutosides /HR/ - orally 600 mg three times daily or intravenously 1000 mg twice a day. A significant decrease of the number of platelet - leukocyte aggregates in the groups of patients receiving HR was found. The type of aggregates after HR was similar to that found in the control group. In 22 patients receiving nicotinic acid derivatives /orally 300 mg three times daily and intramuscularly 300 mg twice a day/ for 3 weeks no significant changes in the parameter investigated was observed. The method of differential counting of platelet-leukocyte aggregates may be of value in early diagnosis of occlusive arterial disease and in evaluation of their therapy.

HAIRLESS LOWER LIMBS AND OCCLUSIVE ARTERIAL DISEASE

The Lancet ◽  
1979 ◽  
Vol 313 (8110) ◽  
pp. 276 ◽  
Author(s):  
Nollaig Parfrey ◽  
JohnF. Ryan ◽  
Laura Shanahan ◽  
MichaelP. Brady
Keyword(s):  
Arterial Disease ◽  
Lower Limbs ◽  
Occlusive Arterial Disease

Effects of Buflomedil Hydrochloride in Occlusive Arterial Disease of the Lower Limbs Stage IV

1986 ◽  
Vol 14 (3) ◽  
pp. 115-123 ◽  
Author(s):  
F Briguglio ◽  
E Briguglio ◽  
V Di Marco ◽  
M Swat ◽  
G Materia ◽  
...  
Keyword(s):  
Treatment Period ◽  
Mechanism Of Action ◽  
Stage Iv ◽  
Complete Recovery ◽  
Arterial Disease ◽  
Skin Lesions ◽  
Lower Limbs ◽  
Occlusive Arterial Disease ◽  
Lesion Regression

Ten patients affected by occlusive arterial disease and presenting with skin lesions of the limbs were treated with buflomedil first i.v. and then orally, at a dosage of 600 mg/day. After a treatment period of 30 to 60 days, eight patients showed lesion regression with complete recovery; the remaining two patients dropped out of the study. The mechanism of action of buflomedil in healing skin lesions is also discussed.

RESULTS OF SURGICAL TREATMENT OF OCCLUSIVE ARTERIAL DISEASE AFFECTING THE LOWER LIMBS, 1953–1967

1970 ◽  
Vol 1 (15) ◽  
pp. 745-754 ◽  
Author(s):  
I. A. Ferguson ◽  
K. N. Morris ◽  
K. E. Stuchbery ◽  
Anne Shanahan ◽  
E. G. Stafford ◽  
...  
Keyword(s):  
Surgical Treatment ◽  
Arterial Disease ◽  
Lower Limbs ◽  
Occlusive Arterial Disease
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