LE cell test and antinuclear antibodies

JAMA ◽  
1967 ◽  
Vol 200 (12) ◽  
pp. 1053-1054 ◽  
Author(s):  
E. L. Dubois
Keyword(s):  
Antinuclear Antibodies ◽  
Cell Test

LE Cell Test and Antinuclear Antibodies

JAMA ◽  
1967 ◽  
Vol 200 (12) ◽  
pp. 1053 ◽  
Author(s):  
Edmund L. Dubois
Keyword(s):  
Antinuclear Antibodies ◽  
Cell Test

Organized Intraglomerular Deposits in NZB Mouse Disease

1971 ◽  
Vol 29 ◽  
pp. 544-545
Author(s):  
Francis R. Comerford ◽  
Alan S. Cohen
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Antinuclear Antibodies ◽  
Human Systemic Lupus Erythematosus ◽  
Systemic Lupus ◽  
Glomerular Lesion ◽  
Ultrastructural Studies ◽  
Dense Deposits ◽  
Experimental Nephritis ◽  
Glomerular Lesions

Mice of the inbred NZB strain develop a spontaneous disease characterized by autoimmune hemolytic anemia, positive lupus erythematosus cell tests and antinuclear antibodies and nephritis. This disease is analogous to human systemic lupus erythematosus. In ultrastructural studies of the glomerular lesion in NZB mice, intraglomerular dense deposits in mesangial, subepithelial and subendothelial locations were described. In common with the findings in many examples of human and experimental nephritis, including many cases of human lupus nephritis, these deposits were amorphous or slightly granular in appearance with no definable substructure.We have recently observed structured deposits in the glomeruli of NZB mice. They were uncommon and were found in older animals with severe glomerular lesions by morphologic criteria. They were seen most commonly as extracellular elements in subendothelial and mesangial regions. The deposits ranged up to 3 microns in greatest dimension and were often adjacent to deposits of lipid-like round particles of 30 to 250 millimicrons in diameter and with amorphous dense deposits.

Antinuclear Antibodies in both Healthy Individuals and Subjects with Raynaud's Phenomenon.

1993 ◽  
Vol 55 (5) ◽  
pp. 915-919 ◽  
Author(s):  
Yoko KOMURA ◽  
Hideyo YOSHIDA ◽  
Setsuya FUJITA ◽  
Ryoichi INABA ◽  
Hirotoshi IWATA
Keyword(s):  
Antinuclear Antibodies ◽  
Raynaud’S Phenomenon ◽  
Raynaud's Phenomenon ◽  
Healthy Individuals

Comparison of the Bidirectional Load Test with the Top-Down Load Test

2005 ◽  
Vol 1936 (1) ◽  
pp. 108-116 ◽  
Author(s):  
Oh Sung Kwon ◽  
Yongkyu Choi ◽  
Ohkyun Kwon ◽  
Myoung Mo Kim
Keyword(s):  
Load Transfer ◽  
Measurement Data ◽  
Load Test ◽  
Load Testing ◽  
Pile Head ◽  
Top Down ◽  
Simple Method ◽  
Testing Method ◽  
Settlement Behavior ◽  
Cell Test

For the past decade, the Osterberg testing method (O-cell test) has been proved advantageous over the conventional pile load testing method in many aspects. However, because the O-cell test uses a loading mechanism entirely different from that of the conventional pile loading testing method, many investigators and practicing engineers have been concerned that the O-cell test would give inaccurate results, especially about the pile head settlement behavior. Therefore, a bidirectional load test using the Osterberg method and the conventional top-down load test were executed on 1.5-m diameter cast-in-place concrete piles at the same time and site. Strain gauges were placed on the piles. The two tests gave similar load transfer curves at various depth of piles. However, the top-down equivalent curve constructed from the bidirectional load test results predicted the pile head settlement under the pile design load to be approximately one half of that predicted by the conventional top-down load test. To improve the prediction accuracy of the top-down equivalent curve, a simple method that accounts for the pile compression was proposed. It was also shown that the strain gauge measurement data from the bidirectional load test could reproduce almost the same top-down curve.

scholarly journals Raynaud's phenomenon and positive antinuclear antibodies in a malignancy.

1990 ◽  
Vol 49 (11) ◽  
pp. 935-936 ◽  
Author(s):  
C Tolosa-Vilella ◽  
J Ordi-Ros ◽  
M Vilardell-Tarres ◽  
A Selva-O'Callaghan ◽  
R Jordana-Comajuncosa
Keyword(s):  
Antinuclear Antibodies ◽  
Raynaud’S Phenomenon ◽  
Raynaud's Phenomenon

scholarly journals Evaluation of the performance of immunoblot and immunodot techniques used to identify autoantibodies in patients with autoimmune diseases

2021 ◽  
Vol 19 (1) ◽  
pp. 237-244
Author(s):  
Youssef EL Hassouni ◽  
Mohammed Bourhia ◽  
Ahmed Bari ◽  
Riaz Ullah ◽  
Hafiz Majid Mahmood ◽  
...  
Keyword(s):  
Immune System ◽  
Autoimmune Diseases ◽  
Indirect Immunofluorescence ◽  
Antinuclear Antibodies ◽  
Pathological Conditions ◽  
Nuclear Antigens ◽  
Significant Difference ◽  
U1 Snrnp

Abstract Autoimmune diseases are pathological conditions in which the immune system mistakenly attacks its own tissues. This study evaluates the performance of two techniques, which are identifiers of autoantibody specifics: immunoblot and immunodot. This study was conducted in 300 patients of whom 62 were tested positive for antinuclear antibodies. The patients were initially screened for antinuclear antibodies using indirect immunofluorescence. Then, the identification of specific autoantibodies such as anti-extractable nuclear antigens (ENAs) was carried out using the immunoblot and immunodot techniques. The results showed that immunoblot and immunodot did not present a significant difference in their sensitivity against anti-SSA/52, SSB, CENP-B, PCNA, U1-snRNP, Jo-1, Pm-scl, and Mi-2 (p > 0.05). However, the two techniques showed a significant difference in their sensitivity toward autoantibodies anti-DNAn, anti-histone, anti-SmD1, and anti-ds-DNA (p < 0.05). The immunoblot data were in complete accordance with the immunodot data (100%) regarding the detection of autoantibodies such as anti SSA/52, SSB, CENP-B, PCNA, U1-snRP, Jo-1, Pm-scl, and Mi-2, 80% regarding SmD1, and 75% concerning ds-DNA. We should certainly pay closer attention to the efficiency of the techniques used in the diagnosis of autoimmune diseases.

THE SIGNIFICANCE OF THE L.E. CELL TEST

1957 ◽  
Vol 1 (26) ◽  
pp. 905-909 ◽  
Author(s):  
D. C. Cowling ◽  
I. D. Thomas
Keyword(s):  
Cell Test
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