Granulomatous prostatitis. Association with isolation of Mycobacterium kansasii and Mycobacterium fortuitum

JAMA ◽  
1977 ◽  
Vol 237 (22) ◽  
pp. 2408-2409 ◽  
Author(s):  
L. W. Lee
Keyword(s):  
Mycobacterium Fortuitum ◽  
Mycobacterium Kansasii ◽  
Granulomatous Prostatitis

Combination of the Topliss Approach with the Free-Wilson Analysis in the Study of Antimycobacterial Activityof 4-Alkylthiobenzanilides

1997 ◽  
Vol 62 (9) ◽  
pp. 1503-1510 ◽  
Author(s):  
Jiří Kuneš ◽  
Jiří Jáchym ◽  
Petr Jirásko ◽  
Želmíra Odlerová ◽  
Karel Waisser
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Mycobacterium Avium ◽  
Steric Effect ◽  
Antimycobacterial Activity ◽  
Mycobacterium Fortuitum ◽  
Mycobacterium Kansasii ◽  
Isopropyl Group ◽  
Butyl Group ◽  
Preliminary Study ◽  
Cyclohexyl Group

On the basis of a preliminary study of the antimycobacterial activity of thiobenzanilides, a group of 4'-isopropyl- and 4'-butylthiobenzanilides have been synthesized and tested against Mycobacterium tuberculosis, Mycobacterium kansasii, Mycobacterium avium and Mycobacterium fortuitum. The effect of the substituents on minimum inhibitory concentrations was calculated by the Free-Wilson method. The separated values were analyzed by the Topliss approach. The substitution of the thiobenzanilide in position 4' by the isopropyl group or butyl group increased the antimycobacterial activity less than the cyclohexyl group. The substitution in position 4 decreased the activity by the steric effect.

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