mycobacterium avium intracellulare
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2021 ◽  
pp. 40-47
Author(s):  
V. V. Skvortsov ◽  
L. V. Zaklyakova ◽  
B. N. Levitan ◽  
M. Yu. Bolgova ◽  
I. K. Zaklyakov ◽  
...  

The definition of gastritis is based on the histological features of the gastric mucosa. This is not the erythema observed during gastroscopy, and there are no specific clinical manifestations or symptoms that determine it. The modern classification of gastritis is based on time (acute and chronic), histological features, anatomical distribution and the main pathological mechanisms. Acute gastritis will develop into chronic if left untreated. Helicobacter pylori (H. pylori) is the most common cause of gastritis worldwide. However, from 60 to 70% H. pylori-negative subjects with functional dyspepsia or non-erosive gastroesophageal reflux were also found to have gastritis. H. pylori-negative gastritis is considered when a person meets all four of these criteria: negative triple staining of biopsies of the gastric mucosa, no history of treatment of H. pylori. In these patients, the cause of gastritis may be associated with tobacco smoking, alcohol consumption and / or the use of nonsteroidal anti-inflammatory drugs (NSAIDs) or steroids. Other causes of gastritis include autoimmune gastritis associated with antibodies of serum anti-parietal and anti-internal factor; organisms other than H. pylori, such as Mycobacterium avium intracellulare, Herpes simplex and Cytomegalovirus; gastritis caused by acid reflux; Rare causes of gastritis include collagen gastritis, sarcoidosis, eosinophilic gastritis and lymphocytic gastritis. The clinical picture, laboratory studies, gastroscopy, as well as histological and microbiological examination of tissue biopsies are important for the diagnosis of gastritis and its causes. Treatment of gastritis caused by H. pylori leads to the rapid disappearance of polymorphic-nuclear infiltration and a decrease in chronic inflammatory infiltrate with gradual normalization of the mucous membrane. Other types of gastritis should be treated based on their etiology.


Author(s):  
Mariana Fernandez-Pittol ◽  
◽  
Yuliya Zboromyrska ◽  
Angely Román ◽  
Griselda Tudó Vilanova ◽  
...  

Objectives. The main objective of the present study is to assess the sensitivity and specificity of a retrospective diagnostic of lymphatic tuberculosis (LTB), testing frozen samples using gene amplification PCR methods. The secondary objective was to compare the results of two different commercial tuberculosis gene amplification methods for this purpose. Material and methods. We retrospectively studied 38 frozen samples, previously processed for mycobacterial culture between January 2014 and August 2019. The results of the previous cultures were: 21 samples positive for Mycobacterium tuberculosis complex (MTB) (5 being smear positive), 7 samples culture positive for Mycobacterium avium-intracellulare complex and 10 samples which were mycobacterial culture negative and discarded for LTB diagnosis, used as controls. The samples were processed using two gene amplification methods: Xpert® MTB/RIF Ultra (Cepheid) and Abbott RealTime MTB Assay (Abbott). Results. Compared to initial culture results the sensitivity and specificity of Xpert® MTB/RIF Ultra were 57.1% and 100% and 52.3 % and 92.5%, respectively for the Abbott RealTime MTB assay. The differences were not statiscally significant. In addition, there were no differences according to the period of freezing. Conclusions. Gene amplification of frozen samples confirmed the diagnosis of lymphatic TB in almost 60% of cases, allowing retrospective diagnosis in initially non suspected cases. Both gene amplification techniques tested were equally useful.


2021 ◽  
Vol 157 (8) ◽  
pp. 408
Author(s):  
Martina Comes Escoda ◽  
Alba Mesa Tudel ◽  
Jose Tomas Navarro Ferrando ◽  
Jose Maria Ribera Santasusana

CHEST Journal ◽  
2021 ◽  
Vol 160 (4) ◽  
pp. A436
Author(s):  
Vihitha Thota ◽  
SANA MULLA ◽  
Sudheer Konduru ◽  
Manaswitha Thota ◽  
Mrunal Sharma

2021 ◽  
Vol 5 (2) ◽  
pp. 88-99
Author(s):  
Chaterine Rahel ◽  
Retno Adriyani ◽  
Hernanda Arie Nurfitria

Natural hot spring is one of the recreational water. The public used it for recreation, relaxation, and therapy. The water quality should meet standards, such as free from microorganisms to prevent the onset of health complaints. This paper aimed to identify the pathogenic microorganisms and recreational water illness in natural hot spring users from worldwide studies. Method: This systematic review analysis use PRISMA Protocol as a guide to provide this article and PEO Framework to specified the criteria. Various database used to find those article is NCBI, Google Scholar, and Science Direct. In total of 10 eligible articles to analyse from 2010 -2020. Discussion: The result showed that hot spring users experienced health complaints after using hot springs contaminated with pathogenic microorganisms. The microorganisms identified were Naegleria spp, Naegleria fowleri, Legionella pneumophila, Vittaforma corneae, Mycobacterium avium-intracellulare Complex (MAC), Pseudomonas aeruginosa, and Mycobacterium phocaicum. Recreation water illnesses identified were Primary Amebic Meningoencephalitis (PAM), Legionella pneumonia, Pseudomonas foliculitis, Pseudomonas mastitis, Microsporidial keratitis, Hot tub lung (HTL), and P. aeruginosa pneumonia. Besides the water quality, age, comorbid, and frequency of visiting hot springs were risk factors of recreational water illness. Conclusion: The onset of recreational water illness in users of hot springs was influenced by the quality of water microbiology and age.


2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Masayuki Nakajima ◽  
Masashi Matsuyama ◽  
Mio Kawaguchi ◽  
Sosuke Matsumura ◽  
Takumi Kiwamoto ◽  
...  

AbstractThe programmed cell death-1 (PD-1) and programmed cell death-ligand 1 (PD-L1) pathway could affect antimicrobial immune responses by suppressing T cell activity. Several recent studies demonstrated that blocking of the PD-1/PD-L1 pathway exacerbated Mycobacterium tuberculosis infection. However, the effect of blocking this pathway in pulmonary Mycobacterium avium–intracellulare complex (MAC) infection is not fully understood. Wild-type, PD-1-deficient mice, and PD-L1-deficient mice were intranasally infected with Mycobacterium avium bacteria. Depletion of PD-1 or PD-L1 did not affect mortality and bacterial burden in MAC-infected mice. However, marked infiltration of CD8-positive T lymphocytes was observed in the lungs of PD-1 and PD-L1-deficient mice compared to wild-type mice. Comprehensive transcriptome analysis showed that levels of gene expressions related to Th1 immunity did not differ according to the genotypes. However, genes related to the activity of CD8-positive T cells and related chemokine activity were upregulated in the infected lungs of PD-1 and PD-L1-deficient mice. Thus, the lack of change in susceptibility to MAC infection in PD-1 and PD-L1-deficient mice might be explained by the absence of obvious changes in the Th1 immune response. Furthermore, activated CD8-positive cells in response to MAC infection in these mice seemed to not be relevant in the control of MAC infection.


Pathogens ◽  
2021 ◽  
Vol 10 (8) ◽  
pp. 920
Author(s):  
Zhihong Yuan ◽  
Zohra Prasla ◽  
Frances Eun-Hyung Lee ◽  
Brahmchetna Bedi ◽  
Roy L. Sutliff ◽  
...  

Non-tuberculous mycobacteria (NTM) have been recognized as a causative agent of various human diseases, including severe infections in immunocompromised patients, such as people living with HIV. The most common species identified is the Mycobacterium avium-intracellulare complex (MAI/MAC), accounting for a majority of infections. Despite abundant information detailing the clinical significance of NTM, little is known about host–pathogen interactions in NTM infection. MicroRNAs (miRs) serve as important post-transcriptional regulators of gene expression. Using a microarray profile, we found that the expression of miR-155 and cyclo-oxygenase 2 (COX-2) is significantly increased in bone-marrow-derived macrophages from mice and human monocyte-derived macrophages from healthy volunteers that are infected with NTM. Antagomir against miR-155 effectively suppressed expression of COX-2 and reduced Prostaglandin E2(PGE2) secretion, suggesting that COX-2/PGE2 expression is dependent on miR-155. Mechanistically, we found that inhibition of NF-κB activity significantly reduced miR-155/COX-2 expression in infected macrophages. Most importantly, blockade of COX-2, E-prostanoid receptors (EP2 and EP4) enhanced killing of MAI in macrophages. These findings provide novel mechanistic insights into the role of miR-155/COX-2/PGE2 signalling and suggest that induction of these pathways enhances survival of mycobacteria in macrophages. Defining host–pathogen interactions can lead to novel immunomodulatory therapies for NTM infections which are difficult to treat.


2021 ◽  
Vol 13 (2) ◽  
pp. 454-464
Author(s):  
Sanu Rajendraprasad ◽  
Christopher Destache ◽  
David Quimby

Nontuberculous mycobacterial (NTM) genitourinary (GU) infections are relatively rare, and there is frequently a delay in diagnosis. Mycobacterium avium-intracellulare complex (MAC) cases seem to be less frequent than other NTM as a cause of these infections. In addition, there are no set treatment guidelines for these organisms in the GU tract. Given the limitations of data this review summarizes a case presentation of this infection and the literature available on the topic. Many different antimicrobial regimens and durations have been used in the published literature. While the infrequency of these infections suggests that there will not be randomized controlled trials to determine optimal therapy, our case suggests that a brief course of amikacin may play a useful role in those who cannot tolerate other antibiotics.


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