Zollinger-Ellison syndrome. Advances in treatment of gastric hypersecretion and the gastrinoma

JAMA ◽  
1994 ◽  
Vol 271 (18) ◽  
pp. 1429-1435 ◽  
Author(s):  
R. T. Jensen
Keyword(s):  
Gastric Hypersecretion ◽  
Zollinger Ellison Syndrome

scholarly journals Mechanism of the Gastric Hypersecretion in the Zollinger-Ellison Syndrome

1962 ◽  
Vol 155 (2) ◽  
pp. 167-174 ◽  
Author(s):  
Stanley R. Freisen ◽  
Hilda J. Tracy ◽  
R. A. Grecory
Keyword(s):  
Gastric Hypersecretion ◽  
Zollinger Ellison Syndrome

Zollinger-Ellison Syndrome in a Nineyear -old Child: A Case Report and Review of this Entity in Childhood

PEDIATRICS ◽  
1971 ◽  
Vol 47 (3) ◽  
pp. 594-598
Author(s):  
Richard M. Buchta ◽  
J. M. Kaplan
Keyword(s):  
Abdominal Pain ◽  
Case Report ◽  
Clinical Data ◽  
Islet Cell ◽  
Islet Cell Tumor ◽  
Cell Tumor ◽  
Gastric Hypersecretion ◽  
Zollinger Ellison Syndrome ◽  
History Of ◽  
Epigastric Abdominal Pain

In 1955, Zollinger and Ellison1 described a syndrome consisting of peptic ulceration, marked gastric hypersecretion, and non-beta islet cell tumor of the pancreas. Although there have been over 300 cases in the adult literature2-5 only 19 patients, 16 years old or younger have been reported. We add one more child to this growing list and review the clinical data of the known cases described. Case Report The patient (R.L.) was a 9-year-old Negro male with a 7-month history of intermittent episodes of mid-epigastric abdominal pain. The pain was somewhat relieved by eating, or the use of antispasmodics. During this period of time, the child had occasional episodes of vomiting, but no melena or hematemesis.

Impaired intestinal absorption in the Zollinger-Ellison syndrome independent of gastric hypersecretion

1970 ◽  
Vol 119 (3) ◽  
pp. 250-253 ◽  
Author(s):  
Hastings K Wright ◽  
Theodore Hersh ◽  
Martin H Floch ◽  
L Donald Weinstein
Keyword(s):  
Intestinal Absorption ◽  
Gastric Hypersecretion ◽  
Zollinger Ellison Syndrome

scholarly journals Mechanism of the Gastric Hypersecretion in the Zollinger-Ellison Syndrome

1962 ◽  
Vol 155 (2) ◽  
pp. 167-174 ◽  
Author(s):  
Stanley R. Freisen ◽  
Hilda J. Tracy ◽  
R. A. Grecory
Keyword(s):  
Gastric Hypersecretion ◽  
Zollinger Ellison Syndrome

Ulcerogenic Tumors of the Pancreas

1968 ◽  
Vol 26 ◽  
pp. 186-187
Author(s):  
J. C. Garancis ◽  
J. F. Kuzma ◽  
S. D. Wilson ◽  
E. H. Ellison
Keyword(s):  
Endoplasmic Reticulum ◽  
Tumor Cells ◽  
Islet Cell ◽  
Disease Process ◽  
Central Core ◽  
Islet Cell Tumors ◽  
Opaque Zone ◽  
Granular Form ◽  
Zollinger Ellison Syndrome

It has been proposed that a gastrin-like hormone elaborated by non-beta islet tumors of the pancreas may be responsible for a fulminating ulcer diathesis. Subsequently, a potent gastric secretagogue was isolated from ulcerogenic tumors of the pancreas. This disease process is known now as “Zollinger-Ellison syndrome”.In our studies of two cases of Zollinger-Ellison syndrome, pancreatic lesions were identified as alpha islet cell tumors (Fig. 1). Tumor cells were fairly uniform. The sizes of the alpha granules were not significantly different, but their number and distribution varied greatly from one cell to another. Each granule consisted of a round, highly dense central core, separated from the limiting membrane by an opaque zone. The granular form of the endoplasmic reticulum was particularly prominent. Numerous mitochondria, round or elongated, were dispersed throughout the cytoplasm. Individual or clusters of lysosomes were observed in the majority of cells.

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