Octreotide: inhibits gastric hypersecretion but does not affect parietal cell mass in Zollinger-Ellison syndrome

InPharma ◽  
1986 ◽  
Vol 530 (1) ◽  
pp. 5-5
Keyword(s):  
Parietal Cell ◽  
Cell Mass ◽  
Gastric Hypersecretion ◽  
Zollinger Ellison Syndrome

Gastric acid secretion and parietal cell mass: effects of thyroidectomy and thyroxine

1989 ◽  
Vol 256 (6) ◽  
pp. G975-G978 ◽  
Author(s):  
K. O. Adeniyi ◽  
M. O. Olowookorun
Keyword(s):  
Gastric Mucosa ◽  
Thyroid Hormones ◽  
Acid Secretion ◽  
Gastric Acid Secretion ◽  
Parietal Cell ◽  
Cell Function ◽  
Cell Mass ◽  
Chronic Administration ◽  
Basal Acid

The role of thyroid hormones on parietal cell function and number was studied in the rat. Chronic administration of thyroxine (6-8 micrograms/100 g body wt/day) for 35 days significantly increased parietal cell mass (from 21.18 +/- 0.13 x 10(6) to 26.71 +/- 0.14 x 10(6] as well as basal acid secretion (from 3.69 +/- 0.08 to 4.99 +/- 0.16 mueq/10 min) and histamine-stimulated acid secretion (from 2.45 +/- 0.12 to 3.69 +/- 0.21 mueq/10 min). Thyroidectomy decreased the number of parietal cells in the gastric mucosa (to 10.48 +/- 0.09 x 10(6] and basal acid secretion (to 3.09 +/- 0.08 mueq/10 min). Histamine (0.2 mg) injection into the thyroidectomized rats increased acid secretion by only 1.41 +/- 0.06 mueq/10 min as against 2.45 +/- 0.12 mueq/10 min obtained for control rats. The results suggest that thyroid hormones regulate basal and secretagogue-stimulated acid secretion via their effects on parietal cell mass.

Helicobacter pylori (HP) does not modify parietal cell mass and acid secretion in duodenal ulcer

1995 ◽  
Vol 108 (4) ◽  
pp. A239
Author(s):  
Gianni Testino ◽  
Matteo Cornaggia ◽  
Alessandro Sumberaz ◽  
Filippo Ansaldi ◽  
Giorgio Ciancamerla
Keyword(s):  
Duodenal Ulcer ◽  
Helicobacter Pylori ◽  
Acid Secretion ◽  
Parietal Cell ◽  
Cell Mass

The Relation between Functioning Parietal Cell and Gastrin Cell Masses in Two Groups of Duodenal Ulcer Patients

1976 ◽  
Vol 50 (5) ◽  
pp. 375-383 ◽  
Author(s):  
D. J. Byrnes ◽  
Shiu Kum Lam ◽  
W. Sircus
Keyword(s):  
Duodenal Ulcer ◽  
Parietal Cell ◽  
Serum Gastrin ◽  
Acid Output ◽  
Ulcer Patient ◽  
Cell Mass ◽  
Inverse Correlation ◽  
Normal Subjects ◽  
Gastrin Cell ◽  
Before And After

1. Serum gastrin concentrations before and after a standardized meal were determined in twenty-eight patients with duodenal ulcer and in ten normal control subjects. 2. In response to pentagastrin, thirteen of the duodenal ulcer subjects secreted acid within the limits of normal and fifteen secreted in excess. 3. The differences in the basal serum gastrin concentrations between the three groups, normal subjects, acid ‘normosecretors’ and hypersecretors were not statistically significant but that of the hypersecretors was suggestively low. 4. The integrated gastrin response and peak gastrin responses to meals were higher in duodenal ulcer patients with normal acid secretion than in the hypersecretors but the values for the latter were not different from normal subjects. 5. Stabilization of intragastric pH by infusion into the antrum of sodium bicarbonate during the test meal response period did not alter these differences between the two ulcer patient groups. 6. A significant inverse correlation exists between the maximal acid output and the integrated gastrin response in both normal subjects and hypersecreting duodenal ulcer patients. 7. The evidence (a) supports the existence of an inverse relationship between the functioning parietal cell and gastrin cell masses, (b) shows the gastrin response in normosecreting ulcer subjects to be inappropriately high, and (c) suggests that excessive vagotonia exerts trophic effects upon both parietal cell mass and gastrin cell mass.

Effect of truncal vagotomy on parietal cell mass and antral gastrin cell mass in dogs

1990 ◽  
Vol 99 (6) ◽  
pp. 1581-1592 ◽  
Author(s):  
Lindsey Inman ◽  
S.Kwon Lee ◽  
Ifat A. Shah ◽  
Richard C. Thirlby ◽  
Mark Feldman
Keyword(s):  
Parietal Cell ◽  
Cell Mass ◽  
Truncal Vagotomy ◽  
Gastrin Cell

scholarly journals Mechanism of the Gastric Hypersecretion in the Zollinger-Ellison Syndrome

1962 ◽  
Vol 155 (2) ◽  
pp. 167-174 ◽  
Author(s):  
Stanley R. Freisen ◽  
Hilda J. Tracy ◽  
R. A. Grecory
Keyword(s):  
Gastric Hypersecretion ◽  
Zollinger Ellison Syndrome

Zollinger-Ellison Syndrome in a Nineyear -old Child: A Case Report and Review of this Entity in Childhood

PEDIATRICS ◽  
1971 ◽  
Vol 47 (3) ◽  
pp. 594-598
Author(s):  
Richard M. Buchta ◽  
J. M. Kaplan
Keyword(s):  
Abdominal Pain ◽  
Case Report ◽  
Clinical Data ◽  
Islet Cell ◽  
Islet Cell Tumor ◽  
Cell Tumor ◽  
Gastric Hypersecretion ◽  
Zollinger Ellison Syndrome ◽  
History Of ◽  
Epigastric Abdominal Pain

In 1955, Zollinger and Ellison1 described a syndrome consisting of peptic ulceration, marked gastric hypersecretion, and non-beta islet cell tumor of the pancreas. Although there have been over 300 cases in the adult literature2-5 only 19 patients, 16 years old or younger have been reported. We add one more child to this growing list and review the clinical data of the known cases described. Case Report The patient (R.L.) was a 9-year-old Negro male with a 7-month history of intermittent episodes of mid-epigastric abdominal pain. The pain was somewhat relieved by eating, or the use of antispasmodics. During this period of time, the child had occasional episodes of vomiting, but no melena or hematemesis.

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