Association Between Visual Field Damage and Gait Dysfunction in Patients With Glaucoma

AbstractThe main goal of this study is to identify the association between corneal shape, elevation, and thickness parameters and visual field damage using machine learning. A total of 676 eyes from 568 patients from the Jichi Medical University in Japan were included in this study. Corneal topography, pachymetry, and elevation images were obtained using anterior segment optical coherence tomography (OCT) and visual field tests were collected using standard automated perimetry with 24-2 Swedish Interactive Threshold Algorithm. The association between corneal structural parameters and visual field damage was investigated using machine learning and evaluated through tenfold cross-validation of the area under the receiver operating characteristic curves (AUC). The average mean deviation was − 8.0 dB and the average central corneal thickness (CCT) was 513.1 µm. Using ensemble machine learning bagged trees classifiers, we detected visual field abnormality from corneal parameters with an AUC of 0.83. Using a tree-based machine learning classifier, we detected four visual field severity levels from corneal parameters with an AUC of 0.74. Although CCT and corneal hysteresis have long been accepted as predictors of glaucoma development and future visual field loss, corneal shape and elevation parameters may also predict glaucoma-induced visual functional loss.

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The cumulative defect curve: Separation of local and diffuse components of visual field damage

Graefe s Archive for Clinical and Experimental Ophthalmology ◽

10.1007/bf02169816 ◽

1989 ◽

Vol 227 (1) ◽

pp. 9-12 ◽

Cited By ~ 46

Author(s):

H. Bebie ◽

J. Flammer ◽

Th. Bebie

Keyword(s):

Visual Field ◽

Visual Field Damage

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Visual Field Damage and Progression in Glaucomatous Myopic Eyes

European Journal of Ophthalmology ◽

10.1177/112067210701700409 ◽

2007 ◽

Vol 17 (4) ◽

pp. 534-537 ◽

Cited By ~ 32

Author(s):

A. Perdicchi ◽

M. Iester ◽

G. Scuderi ◽

S. Amodeo ◽

E.M. Medori ◽

...

Keyword(s):

Visual Field ◽

Open Angle Glaucoma ◽

Linear Regression Analysis ◽

Visual Fields ◽

Light Sensitivity ◽

Progressive Increase ◽

Central Visual Field ◽

Trend Function ◽

Visual Field Damage ◽

Loss Variance

Purpose To make a visual field retrospective analysis on a group of patients with primary open angle glaucoma (POAG) and to evaluate whether different refractive errors could have different progression of the 30° central sensitivity. Methods A total of 110 patients with POAG (52 men and 58 women) were included in the study. All the patients were divided into four subgroups based on the refractive error. The visual field of all the included patients was assessed by an Octopus 30° central visual field every 6 months, for a total of 837 visual fields examined. The resulting data were analyzed by PERIDATA for Windows 1.7 TREND function. Mean defect (MD) and loss variance (LV) were considered for the analysis. Results At the first examination, 82% of eyes showed a global decrease of differential light sensitivity (MD >2 dB) and in 67% the distribution of the defect was nonhomogeneous (LV >6 dB). The analysis of variance for subgroups showed a more significant decrease of MD in highly myopic patients. A linear regression analysis highlighted a statistically significant change in time of MD in 36% and of LV in 34% of the eyes studied. Highly myopic patients had the highest (p<0.01) percentage of change of MD and LV (46% and 42%, respectively). Among the four subgroups, there was no difference in progression of MD decrease in time. Conclusions These results showed that after 5 years of glaucoma, the visual field was altered in most of the eyes examined (82%) and that in 67% of cases, its defect was nonhomogeneous and worsened with the increase of myopia. The regression linear analysis of visual field changes in time showed a progressive increase of MD and LV in approximately one third of all the eyes examined.

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Influence of Carteolol and Timolol on IOP and Visual Fields in Glaucoma: A Multi-Center, Double-Masked, Prospective Study

European Journal of Ophthalmology ◽

10.1177/112067219200200402 ◽

1992 ◽

Vol 2 (4) ◽

pp. 169-174 ◽

Cited By ~ 6

Author(s):

J. Flammer ◽

Y. Kitazawa ◽

L. Bonomi ◽

B. Mills ◽

M. Fsadni ◽

...

Keyword(s):

Visual Field ◽

Prospective Study ◽

Beta Blockers ◽

Visual Fields ◽

Visual Field Defects ◽

Eye Drops ◽

Treatment Groups ◽

Visual Field Damage ◽

One Year ◽

Field Defects

The influences of Carteolol and Timolol eye drops on intraocular pressure (IOP) and visual fields were compared in a multi-center, double-masked, prospective study. Two-hundred and forty eyes of 120 patients were initially included in the study, and 142 eyes of 72 patients fulfilled all the criteria for final statistical analysis. Both drugs significantly reduced IOP. The visual fields in both treatment groups did not change during one year of treatment. In both groups some patients improved slightly, and others deteriorated slightly. This indicates that locally applied beta-blockers may efficiently stop further progression of visual field defects in cases with increased IOP and early visual field damage. There was no difference between Carteolol and Timolol in this regard. The side effects were minimal, and there were no differences in their frequency or intensity in the two treatment groups.

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