Chiral Separations by High‐Performance Liquid Chromatography

2019 ◽  
pp. 1-28
Author(s):  
Karen D. Ward ◽  
Ardith D. Bravenec ◽  
Timothy J. Ward
Keyword(s):  
High Performance Liquid Chromatography ◽  
Liquid Chromatography ◽  
High Performance ◽  
Chiral Separations

Synthesis and Chiral Separation of Some 4-thioflavones

2021 ◽  
Author(s):  
Mohammed El Amin Zaid ◽  
Nasser Belboukhari ◽  
Khaled Sekkoum ◽  
Bousmaha Ibtissam ◽  
Hassan Y Aboul Enein
Keyword(s):  
High Performance Liquid Chromatography ◽  
Liquid Chromatography ◽  
Mobile Phase ◽  
High Performance ◽  
Wittig Reaction ◽  
Stationary Phases ◽  
Enantiomeric Separation ◽  
Chiral Separations ◽  
Chiral Discrimination ◽  
Set Up

Abstract A thionation reaction was performed on some chiral flavanones using Lawesson’s reagent (LR) and leads to the formation of new chiral thiocarbonyl flavanes. LR in this thionation reaction with Hesperetin and Naringenin gives new flavan-4-thiones with yields ranged between 41 and 52%. Based on the Wittig reaction principle, LR is currently the most widely used reagent for this type of reaction. Enantiomeric separation by high-performance liquid chromatography methods was then set-up using three different polysaccharide-based chiral stationary phases (CSPs). Chiral separations were successfully accomplished with high resolution (1.22 ≤ Rs ≤ 5.23). The chiral discrimination mechanism(s) between the analytes under study, mobile phase, and the CSPs were discussed.

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