Mathematical Modelling of Biological Signaling Networks

2008 ◽  
Author(s):  
Jason M. Haugh
Keyword(s):  
Mathematical Modelling ◽  
Signaling Networks ◽  
Biological Signaling Networks

scholarly journals Minimal intervention strategies in logical signaling networks with ASP

2013 ◽  
Vol 13 (4-5) ◽  
pp. 675-690 ◽  
Author(s):  
ROLAND KAMINSKI ◽  
TORSTEN SCHAUB ◽  
ANNE SIEGEL ◽  
SANTIAGO VIDELA
Keyword(s):  
Large Scale ◽  
Quantitative Methods ◽  
Answer Set Programming ◽  
Intervention Strategies ◽  
Signaling Networks ◽  
Fine Grained ◽  
Qualitative Approaches ◽  
Large Scale Networks ◽  
Biological Signaling Networks ◽  
Biological Outcomes

AbstractProposing relevant perturbations to biological signaling networks is central to many problems in biology and medicine because it allows for enabling or disabling certain biological outcomes. In contrast to quantitative methods that permit fine-grained (kinetic) analysis, qualitative approaches allow for addressing large-scale networks. This is accomplished by more abstract representations such as logical networks. We elaborate upon such a qualitative approach aiming at the computation of minimal interventions in logical signaling networks relying on Kleene's three-valued logic and fixpoint semantics. We address this problem within answer set programming and show that it greatly outperforms previous work using dedicated algorithms.

scholarly journals Noise Filtering and Prediction in Biological Signaling Networks

2016 ◽  
Vol 2 (1) ◽  
pp. 16-30 ◽  
Author(s):  
David Hathcock ◽  
James Sheehy ◽  
Casey Weisenberger ◽  
Efe Ilker ◽  
Michael Hinczewski
Keyword(s):  
Signaling Networks ◽  
Noise Filtering ◽  
Biological Signaling Networks

Mathematical modelling of compatibility of normative and criteria evaluations

2012 ◽  
Author(s):  
Aleksandras Krylovas ◽  
Natalja Kosareva ◽  
Olga Navickiene
Keyword(s):  
Mathematical Modelling

In utero exposure to mainstream cigarette smoke alters neonatal pulmonary signaling networks and postnatal lung function

Pneumologie ◽  
2013 ◽  
Vol 67 (12) ◽  
Author(s):  
S Dehmel ◽  
P Nathan ◽  
K Milger ◽  
R Prungnaud ◽  
R Imker ◽  
...  
Keyword(s):  
Lung Function ◽  
Cigarette Smoke ◽  
In Utero ◽  
Signaling Networks ◽  
In Utero Exposure ◽  
Mainstream Cigarette Smoke

In vivo Analysis of Murine Pneumococcal Pneumonia for Mathematical Modelling of Community Aquired Pneumonia

Pneumologie ◽  
2017 ◽  
Vol 71 (S 01) ◽  
pp. S1-S125
Author(s):  
S Berger ◽  
C Gökeri ◽  
U Behrendt ◽  
SM Wienhold ◽  
J Lienau ◽  
...  
Keyword(s):  
Mathematical Modelling ◽  
Pneumococcal Pneumonia ◽  
In Vivo Analysis ◽  
Community Aquired Pneumonia

Mathematical modelling in education and culture

2003 ◽  
Author(s):  
Qi-Xiao Ye ◽  
Werner Blum ◽  
Ken Houston ◽  
Qi-Yuan Jiang
Keyword(s):  
Mathematical Modelling
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