scholarly journals Density-Profile Processes Describing Biological Signaling Networks: Almost Sure Convergence to Deterministic Trajectories

2009 ◽  
Vol 136 (5) ◽  
pp. 875-901 ◽  
Author(s):  
Roberto Fernández ◽  
Luiz R. Fontes ◽  
E. Jordão Neves
2013 ◽  
Vol 13 (4-5) ◽  
pp. 675-690 ◽  
Author(s):  
ROLAND KAMINSKI ◽  
TORSTEN SCHAUB ◽  
ANNE SIEGEL ◽  
SANTIAGO VIDELA

AbstractProposing relevant perturbations to biological signaling networks is central to many problems in biology and medicine because it allows for enabling or disabling certain biological outcomes. In contrast to quantitative methods that permit fine-grained (kinetic) analysis, qualitative approaches allow for addressing large-scale networks. This is accomplished by more abstract representations such as logical networks. We elaborate upon such a qualitative approach aiming at the computation of minimal interventions in logical signaling networks relying on Kleene's three-valued logic and fixpoint semantics. We address this problem within answer set programming and show that it greatly outperforms previous work using dedicated algorithms.


Author(s):  
David Hathcock ◽  
James Sheehy ◽  
Casey Weisenberger ◽  
Efe Ilker ◽  
Michael Hinczewski

1997 ◽  
Vol 91 (4) ◽  
pp. 761-767 ◽  
Author(s):  
D. HENDERSON ◽  
S. SOKOŁOWSKI ◽  
R. ZAGORSKI ◽  
A. TROKHYMCHUK

1981 ◽  
Vol 64 (11) ◽  
pp. 68-74
Author(s):  
Isamu Nagano ◽  
Masayoshi Mambo ◽  
Tetsuo Fukami ◽  
Koji Namba ◽  
Iwane Kimura

Pneumologie ◽  
2013 ◽  
Vol 67 (12) ◽  
Author(s):  
S Dehmel ◽  
P Nathan ◽  
K Milger ◽  
R Prungnaud ◽  
R Imker ◽  
...  

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