Statistical Significance in Biological Sequence Comparison

2008 ◽  
pp. 40-66
Author(s):  
W. R. Pearson ◽  
T. C. Wood
Keyword(s):  
Sequence Comparison ◽  
Statistical Significance ◽  
Biological Sequence ◽  
Biological Sequence Comparison

scholarly journals H-Tuple Approach to Evaluate Statistical Significance of Biological Sequence Comparison with Gaps

2007 ◽  
Vol 6 (1) ◽  
Author(s):  
Afshin Fayyaz movaghar ◽  
Sabine Mercier ◽  
Louis Ferré
Keyword(s):  
Sequence Comparison ◽  
Numerical Experiments ◽  
Statistical Significance ◽  
P Value ◽  
Biological Sequence ◽  
P Values ◽  
Local Score ◽  
Approximate Distribution ◽  
Biological Sequence Comparison ◽  
New Scoring

We propose an approximate distribution for the gapped local score of a two sequence comparison. Our method stands on combining an adapted scoring scheme that includes the gaps and an approximate distribution of the ungapped local score of two independent sequences of i.i.d. random variables. The new scoring scheme is defined on h-tuples of the sequences, using the gapped global score. The influence of h and the accuracy of the p-value are numerically studied and compared with obtained p-value of BLAST. The numerical experiments emphasize that our approximate p-values outperform the BLAST ones, particularly for both simulated and real short sequences.

Parallel Processing of Biological Sequence Comparison Algorithms

1988 ◽  
Author(s):  
Nolan G. Gore ◽  
Elizabeth W. Edmiston ◽  
Joel H. Saltz ◽  
Roger M. Smith
Keyword(s):  
Parallel Processing ◽  
Sequence Comparison ◽  
Biological Sequence ◽  
Biological Sequence Comparison ◽  
Comparison Algorithms

Supercomputers and biological sequence comparison algorithms

1989 ◽  
Vol 22 (6) ◽  
pp. 497-515 ◽  
Author(s):  
Nolan G. Core ◽  
Elizabeth W. Edmiston ◽  
Joel H. Saltz ◽  
Roger M. Smith
Keyword(s):  
Sequence Comparison ◽  
Biological Sequence ◽  
Biological Sequence Comparison ◽  
Comparison Algorithms

Parallel processing of biological sequence comparison algorithms

1988 ◽  
Vol 17 (3) ◽  
pp. 259-275 ◽  
Author(s):  
Elizabeth W. Edmiston ◽  
Nolan G. Core ◽  
Joel H. Saltz ◽  
Roger M. Smith
Keyword(s):  
Parallel Processing ◽  
Sequence Comparison ◽  
Biological Sequence ◽  
Biological Sequence Comparison ◽  
Comparison Algorithms
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