scholarly journals Expression of Thymic Stromal Lymphopoietin in Canine Atopic Dermatitis

Author(s):  
Jolanta Klukowska-Rötzler ◽  
Ludovic Chervet ◽  
Eliane J. Müller ◽  
Petra Roosje ◽  
Eliane Marti ◽  
...  
2013 ◽  
Vol 24 (1) ◽  
pp. 54-e14 ◽  
Author(s):  
Jolanta Klukowska-Rötzler ◽  
Ludovic Chervet ◽  
Eliane J. Müller ◽  
Petra Roosje ◽  
Eliane Marti ◽  
...  

2019 ◽  
Vol 143 (2) ◽  
pp. AB67
Author(s):  
Ichiro Imanishi ◽  
Jumpei Uchiyama ◽  
Takako Matsuda ◽  
Keijiro Mizukami ◽  
Hidekatsu Shimakura ◽  
...  

2021 ◽  
Vol 136 ◽  
pp. 74-80
Author(s):  
Sayaka Shiomitsu ◽  
James Gillen ◽  
Salvatore Frasca ◽  
Domenico Santoro

2013 ◽  
Vol 132 (5) ◽  
pp. 1252-1254 ◽  
Author(s):  
Janneke Landheer ◽  
Barbara Giovannone ◽  
Jeanine D. Mattson ◽  
Sandra Tjabringa ◽  
Carla A.F.M. Bruijnzeel-Koomen ◽  
...  

2017 ◽  
Vol 181 (5) ◽  
pp. 118-118 ◽  
Author(s):  
I. Wagner ◽  
K. J. Geh ◽  
M. Hubert ◽  
G. Winter ◽  
K. Weber ◽  
...  

Cytosine-phosphate-guanine oligodeoxynucleotides (CpG ODN) are a promising new immunotherapeutic treatment option for canine atopic dermatitis (AD). The aim of this uncontrolled pilot study was to evaluate clinical and immunological effects of gelatine nanoparticle (GNP)-bound CpG ODN (CpG GNP) on atopic dogs. Eighteen dogs with AD were treated for 8 weeks (group 1, n=8) or 18 weeks (group 2, n=10). Before inclusion and after 2 weeks, 4 weeks, 6 weeks (group 1+2), 8 weeks, 12 weeks and 16 weeks (group 2) 75 µg CpG ODN/dog (bound to 1.5 mg GNP) were injected subcutaneously. Pruritus was evaluated daily by the owner. Lesions were evaluated and serum concentrations and mRNA expressions of interferon-γ, tumour necrosis factor-α, transforming growth factor-β, interleukin (IL) 10 and IL-4 (only mRNA expression) were determined at inclusion and after 8 weeks (group 1+2) and 18 weeks (group 2). Lesions and pruritus improved significantly from baseline to week 8. Mean improvements from baseline to week 18 were 23 per cent and 44 per cent for lesions and pruritus, respectively, an improvement of ≥50 per cent was seen in six out of nine and three out of six dogs, respectively. IL-4 mRNA expression decreased significantly. The results of this study show a clinical improvement of canine AD with CpG GNP comparable to allergen immunotherapy. Controlled studies are needed to confirm these findings.


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