Sofosbuvir (Sovaldi): The First-in-Class HCV NS5B Nucleotide Polymerase Inhibitor

2015 ◽  
pp. 61-80 ◽  
Author(s):  
Raymond F. Schinazi ◽  
Junxing Shi ◽  
Tony Whitaker
Keyword(s):  
Polymerase Inhibitor ◽  
Hcv Ns5b

Highly Diastereoselective Synthesis of a HCV NS5B Nucleoside Polymerase Inhibitor

2018 ◽  
Vol 84 (8) ◽  
pp. 4780-4795 ◽  
Author(s):  
Yong-Li Zhong ◽  
Ed Cleator ◽  
Zhijian Liu ◽  
Jianguo Yin ◽  
William J. Morris ◽  
...  
Keyword(s):  
Diastereoselective Synthesis ◽  
Polymerase Inhibitor ◽  
Hcv Ns5b

The First Kilogram Synthesis of Beclabuvir, an HCV NS5B Polymerase Inhibitor

2018 ◽  
Vol 22 (10) ◽  
pp. 1393-1408 ◽  
Author(s):  
Jeffrey Bien ◽  
Akin Davulcu ◽  
Albert J. DelMonte ◽  
Kenneth J. Fraunhoffer ◽  
Zhinong Gao ◽  
...  
Keyword(s):  
Ns5b Polymerase Inhibitor ◽  
Polymerase Inhibitor ◽  
Hcv Ns5b ◽  
Ns5b Polymerase

968 GENOTYPIC CHARACTERISATION OF HCV NS5B FOLLOWING 8-DAY MONOTHERAPY WITH THE POLYMERASE INHIBITOR PF-00868554 IN HCV-INFECTED SUBJECTS

2009 ◽  
Vol 50 ◽  
pp. S351 ◽  
Author(s):  
P. Troke ◽  
M. Lewis ◽  
P. Simpson ◽  
E. van der Ryst ◽  
J. Hammond ◽  
...  
Keyword(s):  
Polymerase Inhibitor ◽  
Hcv Ns5b

Discovery of an irreversible HCV NS5B polymerase inhibitor

2013 ◽  
Vol 23 (24) ◽  
pp. 6585-6587 ◽  
Author(s):  
Qingbei Zeng ◽  
Anilkumar G. Nair ◽  
Stuart B. Rosenblum ◽  
Hsueh-Cheng Huang ◽  
Charles A. Lesburg ◽  
...  
Keyword(s):  
Ns5b Polymerase Inhibitor ◽  
Polymerase Inhibitor ◽  
Hcv Ns5b ◽  
Ns5b Polymerase
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