scholarly journals Dosimetric impact of rotational errors on the quality of VMAT‐SRS for multiple brain metastases: Comparison between single‐ and two‐isocenter treatment planning techniques

2020 ◽  
Vol 21 (3) ◽  
pp. 32-44 ◽  
Author(s):  
Georgia Prentou ◽  
Eleftherios P Pappas ◽  
Andreas Logothetis ◽  
Efi Koutsouveli ◽  
Evaggelos Pantelis ◽  
...  
Keyword(s):  
Brain Metastases ◽  
Treatment Planning ◽  
Planning Techniques ◽  
Multiple Brain Metastases

Quality of Life following Stereotactic Radiosurgery for Single and Multiple Brain Metastases

2016 ◽  
Vol 96 (2) ◽  
pp. E536
Author(s):  
J.A. Miller ◽  
R. Kotecha ◽  
G.H. Barnett ◽  
J.H. Suh ◽  
L. Angelov ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Brain Metastases ◽  
Stereotactic Radiosurgery ◽  
Multiple Brain Metastases

scholarly journals HyperArc VMAT planning for single and multiple brain metastases stereotactic radiosurgery: a new treatment planning approach

2018 ◽  
Vol 13 (1) ◽  
Author(s):  
Shingo Ohira ◽  
Yoshihiro Ueda ◽  
Yuichi Akino ◽  
Misaki Hashimoto ◽  
Akira Masaoka ◽  
...  
Keyword(s):  
Brain Metastases ◽  
Stereotactic Radiosurgery ◽  
Treatment Planning ◽  
Multiple Brain Metastases ◽  
Planning Approach ◽  
New Treatment

scholarly journals Training and evaluation of a knowledge-based model for automated treatment planning of multiple brain metastases

2019 ◽  
Vol 2019 ◽  
Author(s):  
Vishruta A. Dumane ◽  
Tsu-Chi Tseng ◽  
Ren-Dih Sheu ◽  
Yeh-Chi Lo ◽  
Vishal Gupta ◽  
...  
Keyword(s):  
Brain Metastases ◽  
Treatment Planning ◽  
Multiple Brain Metastases ◽  
Knowledge Based

SU-E-T-672: Comparisons of Single and Multiple Isocenter Stereotactic IMRT Treatment Planning for Multiple Brain Metastases Treatment

2013 ◽  
Vol 40 (6Part21) ◽  
pp. 360-360 ◽  
Author(s):  
S Hossain ◽  
O Algan ◽  
I Ali ◽  
J Young ◽  
S Ahmad
Keyword(s):  
Brain Metastases ◽  
Treatment Planning ◽  
Multiple Brain Metastases

scholarly journals Randomised prospective phase II trial in multiple brain metastases comparing outcomes between hippocampal avoidance whole brain radiotherapy with or without simultaneous integrated boost: HA-SIB-WBRT study protocol

BMC Cancer ◽  
2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Brendan Seng Hup Chia ◽  
Jing Yun Leong ◽  
Ashley Li Kuan Ong ◽  
Cindy Lim ◽  
Shi Hui Poon ◽  
...  
Keyword(s):  
Brain Metastases ◽  
Whole Brain Radiotherapy ◽  
Target Lesion ◽  
Whole Brain ◽  
Tumour Control ◽  
Multiple Brain Metastases ◽  
Brain Radiotherapy ◽  
Hippocampal Avoidance ◽  
Integrated Boost

Abstract Background Recent evidence supports hippocampal avoidance with whole brain radiotherapy (HA-WBRT) as the recommended treatment option in patients with good prognosis and multiple brain metastases as this results in better neurocognitive preservation compared to whole brain radiotherapy. However, there is often poor tumour control with this technique due to the low doses given. Stereotactic Radiosurgery (SRS), a form of focused radiotherapy which is given to patients who have a limited number of brain metastases, delivers a higher radiation dose to the metastases resulting in better target lesion control. With improvements in radiation technology, advanced dose-painting techniques now allow a simultaneous integrated boost (SIB) dose to lesions whilst minimising doses to the hippocampus to potentially improve brain tumour control and preserve cognitive outcomes. This technique is abbreviated to HA-SIB-WBRT or HA-WBRT+SIB. Methods We hypothesise that the SIB in HA-SIB-WBRT (experimental arm) will result in better tumour control compared to HA-WBRT (control arm). This may also lead to better intracranial disease control as well as functional and survival outcomes. We aim to conduct a prospective randomised phase II trial in patients who have good performance status, multiple brain metastases (4–25 lesions) and a reasonable life expectancy (> 6 months). These patients will be stratified according to the number of brain metastases and randomised between the 2 arms. We aim for a recruitment of 100 patients from a single centre over a period of 2 years. Our primary endpoint is target lesion control. These patients will be followed up over the following year and data on imaging, toxicity, quality of life, activities of daily living and cognitive measurements will be collected at set time points. The results will then be compared across the 2 arms and analysed. Discussion Patients with brain metastases are living longer. Maintaining functional independence and intracranial disease control is thus increasingly important. Improving radiotherapy treatment techniques could provide better control and survival outcomes whilst maintaining quality of life, cognition and functional capacity. This trial will assess the benefits and possible toxicities of giving a SIB to HA-WBRT. Trial registration Clinicaltrials.gov identifier: NCT04452084. Date of registration 30th June 2020.

Multiple intracranial metastases of malignant melanoma with long-term survival

1984 ◽  
Vol 60 (3) ◽  
pp. 621-624 ◽  
Author(s):  
Eduardo Fernandez ◽  
Giulio Maira ◽  
Alfredo Puca ◽  
Andrea Vignati
Keyword(s):  
Malignant Melanoma ◽  
Brain Metastases ◽  
Term Survival ◽  
Long Term Survival ◽  
Content Type ◽  
Multiple Brain Metastases ◽  
Intracranial Metastases ◽  
Fine Print

✓ The authors present a case of multiple brain metastases and an extracranial secondary localization from malignant melanoma. The patient was operated on three times for the intracranial masses and had a 49-month survival with a good quality of life after the first of the three operations. She lived a total of 80 months from the time of diffusion of the primary tumor. The course of malignant melanoma is unpredictable, and long-term survival can be achieved in some cases, even in the presence of multiple brain metastases.

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