Multiple intracranial metastases of malignant melanoma with long-term survival

1984 ◽  
Vol 60 (3) ◽  
pp. 621-624 ◽  
Author(s):  
Eduardo Fernandez ◽  
Giulio Maira ◽  
Alfredo Puca ◽  
Andrea Vignati
Keyword(s):  
Malignant Melanoma ◽  
Brain Metastases ◽  
Term Survival ◽  
Long Term Survival ◽  
Content Type ◽  
Multiple Brain Metastases ◽  
Intracranial Metastases ◽  
Fine Print

✓ The authors present a case of multiple brain metastases and an extracranial secondary localization from malignant melanoma. The patient was operated on three times for the intracranial masses and had a 49-month survival with a good quality of life after the first of the three operations. She lived a total of 80 months from the time of diffusion of the primary tumor. The course of malignant melanoma is unpredictable, and long-term survival can be achieved in some cases, even in the presence of multiple brain metastases.

The influence of sex and the presence of giant cells on postoperative long-term survival in adult patients with supratentorial glioblastoma multiforme

2004 ◽  
Vol 101 (2) ◽  
pp. 219-226 ◽  
Author(s):  
Naoki Shinojima ◽  
Masato Kochi ◽  
Jun-Ichiro Hamada ◽  
Hideo Nakamura ◽  
Shigetoshi Yano ◽  
...  
Keyword(s):  
Glioblastoma Multiforme ◽  
Giant Cell ◽  
Adult Patients ◽  
Term Survival ◽  
Long Term Survival ◽  
Content Type ◽  
Free Interval ◽  
Younger Age ◽  
Fine Print

Object. Glioblastoma multiforme (GBM) remains incurable by conventional treatments, although some patients experience long-term survival. A younger age, a higher Karnofsky Performance Scale (KPS) score, more aggressive treatment, and long progression-free intervals have been reported to be positively associated with long-term postoperative patient survival. The aim of this retrospective study was the identification of additional favorable prognostic factors affecting long-term survival in surgically treated adult patients with supratentorial GBM. Methods. Of 113 adult patients newly diagnosed with histologically verified supratentorial GBM who were enrolled in Phase III trials during the period between 1987 and 1998, six (5.3%) who survived for longer than 5 years were defined as long-term survivors, whereas the remaining 107 patients served as controls. All six were women and were compared with the controls; they were younger (mean age 44.2 years, range 31–60 years), and their preoperative KPS scores were higher (mean 85, range 60–100). Four of the six patients underwent gross-total resection. In five patients (83.3%) the progression-free interval was longer than 5 years and in three a histopathological diagnosis of giant cell GBM was made. This diagnosis was not made in the other 107 patients. Conclusions. Among adult patients with supratentorial GBM, female sex and histopathological characteristics consistent with giant cell GBM may be predictive of a better survival rate, as may traditional factors (that is, younger age, good KPS score, more aggressive resection, and a long progression-free interval).

scholarly journals Long-term survival of patients after ipilimumab and hypofractionated brain radiotherapy for brain metastases of malignant melanoma: sequence matters

2018 ◽  
Vol 194 (12) ◽  
pp. 1144-1151 ◽  
Author(s):  
Heinz Schmidberger ◽  
Matthias Rapp ◽  
Anne Ebersberger ◽  
Silla Hey-Koch ◽  
Carmen Loquai ◽  
...  
Keyword(s):  
Malignant Melanoma ◽  
Brain Metastases ◽  
Term Survival ◽  
Long Term Survival ◽  
Brain Radiotherapy

Repeated gamma knife surgery for multiple brain metastases from renal cell carcinoma

2002 ◽  
Vol 97 (4) ◽  
pp. 785-793 ◽  
Author(s):  
Berndt Wowra ◽  
Michael Siebels ◽  
Alexander Muacevic ◽  
Friedrich Wilhelm Kreth ◽  
Andreas Mack ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Brain Metastases ◽  
Cell Carcinoma ◽  
Gamma Knife ◽  
Renal Cell ◽  
Radiation Toxicity ◽  
Content Type ◽  
Multiple Brain Metastases ◽  
Fine Print

Object. The aim of this study was to evaluate the therapeutic profile of repeated gamma knife surgery (GKS) for renal cell carcinoma that has metastasized to the brain on multiple occasions. Methods. Data from this study were culled from a single institution and cover a 6-year period of outpatient radiosurgery. A standard protocol for indication, dose planning, and follow up was established. In cases of distant or local recurrences, radiosurgery was undertaken repeatedly (up to six times in one individual). Seventy-five patients harboring 350 cerebral metastases were treated. Relief from pretreatment neurological symptoms occurred in 72% of patients within a few days or a few weeks after the procedure. The actuarial local tumor control rate after the initial GKS was 95%. In patients free from relapse of intracranial metastases after repeated radiosurgery, long-term survival was 91% after 4 years; median survival was 11.1 ± 3.2 months after radiosurgery and 4.5 ± 1.1 years after diagnosis of the primary kidney cancer. Survival following radiosurgery was independent of patient age and sex, side of the renal cell carcinoma, pretreatment of the cerebrum by using radiotherapy or surgery, number of brain metastases and their synchronization with the primary renal cell carcinoma, and the frequency of radiosurgical procedures. In contrast, survival was dependent on the patient's clinical performance score and the extracranial tumor status. Tumor bleeding was observed in seven patients (9%) and late radiation toxicity (LRT) in 15 patients (20%). Treatment-related morbidity was moderate and mostly transient. Late radiation toxicity was encountered predominantly in long-term survivors. Conclusions. Outpatient repeated radiosurgery is an effective and only minimally invasive treatment for multiple brain metastases from renal cell cancer and is recommended as being the method of choice to control intracranial disease, especially in selected patients with limited extracranial disease. Physicians dealing with such patients should be aware of the characteristic aspects of LRT.

Quality of long-term survival in young children with medulloblastoma

1994 ◽  
Vol 80 (6) ◽  
pp. 1004-1010 ◽  
Author(s):  
Dennis L. Johnson ◽  
Mary Ann McCabe ◽  
H. Stacy Nicholson ◽  
Amy L. Joseph ◽  
Pamela R. Getson ◽  
...  
Keyword(s):  
Neuropsychological Testing ◽  
Motor Task ◽  
Achievement Test ◽  
Physical Growth ◽  
Term Survival ◽  
Content Type ◽  
Long Term Survivors ◽  
Fine Print

✓ The reported success of treatment for children with medulloblastoma must be balanced against the effect that treatment has on the quality of life of long-term survivors. The outcome of long-term survivors reported in previous studies has been conflicting. The authors evaluate the mental and behavioral skills of a group of medulloblastoma survivors from their institution, all of whom had survived for more than 5 years postdiagnosis. A review of the institutional records yielded 32 patients. Twenty-three families were interviewed by telephone and, of these, 13 subjects came to the hospital for detailed neuropsychological and neurological evaluations. Intelligence quotient (IQ) was less than 90 for all participants tested, and patients diagnosed before the age of 3 years had lower IQ scores on average than those diagnosed later. Mean IQ and achievement test scores in reading, spelling, and mathematics were all higher in survivors who had undergone shunting. Achievement test results were often not in accord with intellectual potential, and individual intellectual skills varied widely. Perceptual-motor task performance was below average in more than 50% of the participants, but motor dexterity was more severely affected than perception. Problems in learning and a delay in both physical growth and development were seen in a majority of participants. This study directs attention to the serious difficulties faced by long-term survivors of medulloblastoma and their families, and underscores the importance of routine neuropsychological testing. Moreover, the study provides further impetus to seek alternatives to irradiation in the treatment of malignant brain tumors.

Malignant transformation of ganglioneuroma into spinal neuroblastoma in an adult

1998 ◽  
Vol 88 (2) ◽  
pp. 324-327 ◽  
Author(s):  
Abhaya V. Kulkarni ◽  
Juan M. Bilbao ◽  
Michael D. Cusimano ◽  
Paul J. Muller
Keyword(s):  
Malignant Transformation ◽  
Benign Tumor ◽  
Ganglion Cells ◽  
Term Survival ◽  
Long Term Survival ◽  
Content Type ◽  
First Report ◽  
Fine Print

✓ Ganglioneuroma is generally considered to be a benign tumor and potentially surgically curable. The authors present a case of a 21-year-old woman who underwent resection of a retroperitoneal ganglioneuroma and developed spinal neuroblastoma 11 years later. She has survived 10 more years with only recent development of metastases. To the authors' knowledge, this is the first report of malignant transformation of a ganglioneuroma into a neuroblastoma. Also, such long-term survival in an adult with spinal neuroblastoma has not been reported previously. This case raises the possibility of a dedifferentiating potential for ganglion cells in a ganglioneuroma or the presence of a long-term, quiescent form of neuroblastoma.

scholarly journals A Long-term Survival Case After Removal of Synchronous, Multiple, Brain Metastases Followed by Resection of Lung Cancer.

Haigan ◽  
2002 ◽  
Vol 42 (1) ◽  
pp. 45-49
Author(s):  
Kazuya Fujinaga ◽  
Motoshi Takao ◽  
Fumiaki Watanabe ◽  
Shinji Kanemitsu ◽  
Hideto Shimpo ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Brain Metastases ◽  
Term Survival ◽  
Long Term Survival ◽  
Multiple Brain Metastases ◽  
Survival Case

The neurosurgical management of optic glioma

1982 ◽  
Vol 57 (4) ◽  
pp. 452-458 ◽  
Author(s):  
Robert T. Tenny ◽  
Edward R. Laws ◽  
Brian R. Younge ◽  
James A. Rush
Keyword(s):  
Survival Rate ◽  
Optic Nerve ◽  
Optic Chiasm ◽  
Optic Glioma ◽  
Review Of The Literature ◽  
Term Survival ◽  
Long Term Survival ◽  
Content Type ◽  
Fine Print

✓ A series of 104 patients with surgically verified optic nerve gliomas is presented. Anterior lesions primarily affecting the optic nerve were present in 42 patients, who have a long-term survival rate of 85.5%. Posterior lesions primarily affecting the optic chiasm were present in 62 patients, most of whom underwent radiation therapy postoperatively, and they have a long-term survival rate of 50%. Unequivocal signs of neurofibromatosis were present in 14%. On the basis of these findings and a review of the literature, recommendations are made for the surgical management of these tumors.

Long-term survival of patients treated with BCNU for brain tumors

1975 ◽  
Vol 43 (2) ◽  
pp. 191-196 ◽  
Author(s):  
John Calogero ◽  
David C. Crafts ◽  
Charles B. Wilson ◽  
Edwin B. Boldrey ◽  
Alan Rosenberg ◽  
...  
Keyword(s):  
Brain Tumors ◽  
Potential Role ◽  
Term Survival ◽  
Glial Tumors ◽  
Long Term Survival ◽  
Content Type ◽  
Fine Print

✓The authors present three patients who, after excision and irradiation of their brain tumors, were treated with BCNU for recurrence. All three patients responded well and now are without evidence of tumor, 37, 30, and 36 months after BCNU was stopped. Although these patients represent only a small fraction of those treated with BCNU, they indicate the potential role of chemotherapy in the management of glial tumors.

Deformity correction and long-term survival in an infant with iniencephaly

1991 ◽  
Vol 75 (1) ◽  
pp. 126-130 ◽  
Author(s):  
John J. Gartman ◽  
Thomas E. Melin ◽  
W. Thomas Lawrence ◽  
Stephen K. Powers
Keyword(s):  
Deformity Correction ◽  
Male Infant ◽  
Term Survival ◽  
Long Term Survival ◽  
Content Type ◽  
Cervical Deformity ◽  
Neurosurgical Intervention ◽  
Fine Print

✓ The authors describe the case of a male infant who was diagnosed prenatally as having iniencephaly. Since birth, the child has grown, thrived, and undergone two successful operations to correct his cervical deformity. This case demonstrates that the iniencephaly defect is not uniformly fatal and that neurosurgical intervention may offer significant improvement in the cervical deformity.

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