Intermolecular Cyclopropanation of Iodonium Ylides and Electron-Deficient Alkenes through a Highly Efficient Catalyst-Free Process

2018 ◽  
Vol 7 (10) ◽  
pp. 2065-2068 ◽  
Author(s):  
Xiang Zhang ◽  
Rong Zeng ◽  
Xin Feng ◽  
Qing-Song Dai ◽  
Yue Liu ◽  
...  
Keyword(s):  
Efficient Catalyst ◽  
Catalyst Free ◽  
Highly Efficient ◽  
Free Process ◽  
Iodonium Ylides

Highly Efficient, Catalyst-Free, Diastereoselective, Diversity-Oriented Synthesis of Dihydrocoumarin–Pyrrolidine–Spirooxindoles Bearing Three Contiguous Stereocenters

Synthesis ◽  
2019 ◽  
Vol 51 (11) ◽  
pp. 2339-2350 ◽  
Author(s):  
Xiong Zuo ◽  
Shuang Chen ◽  
Sheng-Wen Xu ◽  
Shun-Qin Chang ◽  
Xiong-Li Liu ◽  
...  
Keyword(s):  
Carboxylic Acid ◽  
Bioactive Molecules ◽  
Acid Activation ◽  
Efficient Catalyst ◽  
Diversity Oriented Synthesis ◽  
Efficient Approach ◽  
Catalyst Free ◽  
Highly Efficient

A new methodology has been developed for the highly efficient diastereoselective construction of dihydrocoumarin–pyrrolidine–spirooxindole collections via a domino Michael/annulation reaction of 3-isothiocyanato oxindoles and coumarins under catalyst-free conditions. The resulting biologically important molecules bearing three pharmacophores and three contiguous stereocenters were obtained in up to 92% yield and >20:1 dr. It is noteworthy that utilization of a carboxylic acid activation/decarboxylation strategy represents an efficient approach for the domino Michael/annulation reaction of the chemically inert coumarin moiety. This protocol could expand candidate libraries, that will benefit the requirement for new bioactive molecules.

High-sensitivity stimuli-responsive polysiloxane synthesized via catalyst-free aza-Michael addition for ibuprofen loading and controlled release

RSC Advances ◽  
2016 ◽  
Vol 6 (101) ◽  
pp. 99414-99421 ◽  
Author(s):  
Shusheng Li ◽  
Shengyu Feng
Keyword(s):  
Controlled Release ◽  
Michael Addition ◽  
High Sensitivity ◽  
Stimuli Responsive ◽  
Efficient Catalyst ◽  
Catalyst Free ◽  
Highly Efficient

High-sensitive stimuli-responsive polysiloxanes with high sensitive respond to three changes of thermo-, pH-, and salinity were synthesized via a facile, highly efficient, catalyst-free aza-Michael addition of poly(aminopropylmethylsiloxane) with N-isopropylacrylamide.

From LCST to UCST: the phase separation behaviour of thermo-responsive polysiloxanes with the solubility parameters of solvents

2017 ◽  
Vol 41 (5) ◽  
pp. 1997-2003 ◽  
Author(s):  
Shusheng Li ◽  
Linglong Feng ◽  
Hang Lu ◽  
Shengyu Feng
Keyword(s):  
Phase Separation ◽  
Michael Addition ◽  
Mixed Solvents ◽  
Solubility Parameters ◽  
Efficient Catalyst ◽  
Catalyst Free ◽  
Highly Efficient ◽  
Type Phase

Thermo-responsive polysiloxanes with tunable LCST- and UCST-type phase separation in mixed solvents were synthesised via a facile, highly efficient, catalyst-free aza-Michael addition of poly(aminopropylmethylsiloxane) to N-isopropylacrylamide.

ChemInform Abstract: A Highly Efficient Catalyst-Free Cycloisomerization Approach to Indolizinones.

ChemInform ◽  
2009 ◽  
Vol 40 (4) ◽  
Author(s):  
Ikyon Kim ◽  
Jihyun Choi ◽  
Sunkyung Lee ◽  
Ge Hyeong Lee
Keyword(s):  
Efficient Catalyst ◽  
Catalyst Free ◽  
Highly Efficient
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