Efficient Trapping of Oxonium Ylides with Imines: A Highly Diastereoselective Three-Component Reaction for the Synthesis of β-Amino-α-hydroxyesters with Quaternary Stereocenters

2007 ◽  
Vol 119 (8) ◽  
pp. 1359-1361 ◽  
Author(s):  
Haoxi Huang ◽  
Xin Guo ◽  
Wenhao Hu
Keyword(s):  
Three Component Reaction ◽  
Oxonium Ylides ◽  
Quaternary Stereocenters

A gold(i)-catalysed three-component reaction via trapping oxonium ylides with allenamides

2019 ◽  
Vol 55 (84) ◽  
pp. 12675-12678 ◽  
Author(s):  
Gengxin Liu ◽  
Sifan Yu ◽  
Wenhao Hu ◽  
Huang Qiu
Keyword(s):  
Three Component Reaction ◽  
Oxonium Ylides ◽  
Allylic Ethers

A gold(i)-catalysed three-component reaction between alcohols (and water), α-aryl-α-diazoesters and allenamides is reported, affording tert-allylic ethers (and alcohols), in moderate to excellent yields with excellent geometric selectivity.

A Rh-catalyzed three-component reaction for the diastereoselective synthesis of pyrazolone derivatives with contiguous quaternary stereocenters

2020 ◽  
Vol 18 (18) ◽  
pp. 3466-3470
Author(s):  
Chaoqun Ao ◽  
Jingjing Huang ◽  
Xinfang Xu ◽  
Shikun Jia ◽  
Zhenghui Kang ◽  
...  
Keyword(s):  
Diastereoselective Synthesis ◽  
Efficient Approach ◽  
Pyrazolone Derivatives ◽  
Three Component Reaction ◽  
Quaternary Stereocenters

Efficient approach for the facile construction of polyfunctionalized pyrazolone derivatives bearing two contiguous quaternary stereocenters in good yields with high regioselectivities and excellent diastereoselectivities.

Visible Light-Induced Sulfonylation/Arylation of Styrenes in a Double Radical Three-Component Photoredox Reaction

2019 ◽  
Author(s):  
Benjamin Lipp ◽  
Lisa Marie Kammer ◽  
Murat Kucukdisli ◽  
Adriana Luque ◽  
Jonas Kühlborn ◽  
...  
Keyword(s):  
Visible Light ◽  
Radical Formation ◽  
Three Component Reaction ◽  
Broad Variety ◽  
Styrene Derivatives ◽  
Mechanistic Investigations

Simultaneous sulfonylation/arylation of styrene derivatives is achieved in a photoredox-catalyzed three-component reaction using visible light. A broad variety of difunctionalized products is accessible in mostly excellent yields and high diastereoselectivity. The developed reaction is scalable and suitable for the modification of styrene-functionalized biomolecules. Mechanistic investigations suggest the transformation to be operating through a designed sequence of radical formation and radical combination.<br>

SiO2-POCl2 nano-particles promoted the synthesis of novel structure of alkyl 2-oxo-3,4-diaryloxazolidine-5-carboxylate derivatives

2020 ◽  
Vol 17 ◽  
Author(s):  
Mehdi Abaszadeh ◽  
Seyyed Jalal Roudbaraki ◽  
Hossein Yarahmadi ◽  
Majid Ghashang
Keyword(s):  
Nano Particles ◽  
Methyl Ethyl ◽  
Aniline Derivatives ◽  
Ethyl Methyl ◽  
Novel Structure ◽  
Three Component Reaction ◽  
High Yields

: Silica-POCl2 was used as the promoter for the three-component reaction of ethyl/methyl 3-phenyl glycidate, aniline derivatives, and dimethylcarbonate, leads to the synthesis of methyl/ethyl 2-oxo-4-phenyl-3-aryloxazolidine-5-carboxylate derivatives. The desired product was obtained in high yields.

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