SiO2-POCl2 nano-particles promoted the synthesis of novel structure of alkyl 2-oxo-3,4-diaryloxazolidine-5-carboxylate derivatives

: Silica-POCl2 was used as the promoter for the three-component reaction of ethyl/methyl 3-phenyl glycidate, aniline derivatives, and dimethylcarbonate, leads to the synthesis of methyl/ethyl 2-oxo-4-phenyl-3-aryloxazolidine-5-carboxylate derivatives. The desired product was obtained in high yields.

Novel One-pot Synthesis of Pyranocarbazole Derivatives via an Isocyanide-based Three-component Reaction

Letters in Organic Chemistry ◽

10.2174/1570178617999201020215852 ◽

2020 ◽

Vol 17 ◽

Author(s):

Visarapu Malathi ◽

Pedavenkatagari Narayana Reddy ◽

Pannala Padmaja

Keyword(s):

Efficient Method ◽

Atom Economy ◽

Reaction Conditions ◽

One Pot ◽

Catalyst Free ◽

One Pot Synthesis ◽

Abstract:: An efficient method has been developed for the synthesis of new pyrano[3,2-c] and pyrano[3,2-a]carbazole de-rivatives via a three component reaction of 4-hydroxycarbazole or 2-hydroxycarbazole, isocyanides, and dialkylacetylenedi-carboxylates. Noteworthy features of this protocol include mild reaction conditions, catalyst-free, high atom-economy and high yields.

DNA-binding studies and antioxidant activities of two-, three- and four-coordinate silver(i) complexes containing bis(2-benzimidazolyl)aniline derivatives

New Journal of Chemistry ◽

10.1039/c4nj00503a ◽

2014 ◽

Vol 38 (8) ◽

pp. 3688-3698 ◽

Cited By ~ 36

Author(s):

Huilu Wu ◽

Yanhui Zhang ◽

Chengyong Chen ◽

Jiawen Zhang ◽

Yuchen Bai ◽

...

Keyword(s):

Dna Binding ◽

Hydroxyl Radical ◽

Superoxide Radical ◽

Antioxidant Activities ◽

Binding Studies ◽

Aniline Derivatives ◽

Novel Structure ◽

Dna Binding Studies

Three novel structure Ag(i) complexes have been synthesized and characterized. The three ligands and Ag(i) complexes bind to DNA in an intercalation mode. The Ag(i) complexes have stronger ability of antioxidation for hydroxyl radical and superoxide radical.

Synthesis of spiro[dihydropyridine-oxindoles] via three-component reaction of arylamine, isatin and cyclopentane-1,3-dione

Beilstein Journal of Organic Chemistry ◽

10.3762/bjoc.9.2 ◽

2013 ◽

Vol 9 ◽

pp. 8-14 ◽

Cited By ~ 28

Author(s):

Yan Sun ◽

Jing Sun ◽

Chao-Guo Yan

Keyword(s):

Acetic Acid ◽

Reaction Mechanism ◽

Room Temperature ◽

The Other ◽

Other Hand ◽

A fast and convenient protocol for the synthesis of novel spiro[dihydropyridine-oxindole] derivatives in satisfactory yields was developed by the three-component reactions of arylamine, isatin and cyclopentane-1,3-dione in acetic acid at room temperature. On the other hand the condensation of isatin with two equivalents of cyclopentane-1,3-dione gave 3,3-bis(2-hydroxy-5-oxo-cyclopent-1-enyl)oxindole in high yields. The reaction mechanism and substrate scope of this novel reaction is briefly discussed.

A Simple and Efficient Synthesis of Highly Substituted Indeno[1,2-b]pyrrole and Acenaphtho[1,2-b]pyrrole Derivatives by Tandem Three-Component Reactions

Molecules ◽

10.3390/molecules23113031 ◽

2018 ◽

Vol 23 (11) ◽

pp. 3031 ◽

Cited By ~ 2

Author(s):

Xiaodong Tang ◽

Songlei Zhu ◽

Ying Ma ◽

Ren Wen ◽

Lanqi Cen ◽

...

Keyword(s):

Environmentally Benign ◽

Efficient Synthesis ◽

Reaction Conditions ◽

Dicarbonyl Compounds ◽

Pyrrole Derivatives ◽

High Yields ◽

Operational Simplicity

A green, convenient and tandem procedure for the efficient synthesis of highly substituted indeno[1,2-b]pyrrole and acenaphtho[1,2-b]pyrrole derivatives by domino three-component reaction of tryptamine/benzylamine, 1,3-dicarbonyl compounds and ninhydrin/ acenaphthenequinone is described. The significant features of this procedure were characterized by mild reaction conditions, high yields, operational simplicity and it being environmentally benign.

Behaviour of isomeric methyl ethyl and ethyl methyl halosuccinates under electron impact. Elimination of a halogen atom by a multi-step mechanism

Organic Mass Spectrometry ◽

10.1002/oms.1210260917 ◽

1991 ◽

Vol 26 (9) ◽

pp. 793-798 ◽

Cited By ~ 4

Author(s):

D. Bornstein ◽

A. Mandelbaum ◽

I. Vidavsky ◽

B. Domon ◽

D. Mueller ◽

...

Keyword(s):

Electron Impact ◽

Halogen Atom ◽

Methyl Ethyl ◽

Ethyl Methyl ◽

Step Mechanism ◽

Isomeric Methyl

Zn(L-proline)2: An efficient and reusable organocatalyst for the synthesis of polyfunctionally substituted pyrans and 2-amino-4-aryl-8-oxo-4,8-dihydropyrano[3,2-b]pyran derivatives

European Journal of Chemistry ◽

10.5155/eurjchem.10.2.166-170.1851 ◽

2019 ◽

Vol 10 (2) ◽

pp. 166-170 ◽

Cited By ~ 2

Author(s):

Fatma Ahmed Abo Elsoud ◽

Mohamed Abd-Elmonem ◽

Mohamed Abo Elsebaa ◽

Kamal Usef Sadek

Keyword(s):

Kojic Acid ◽

Aromatic Aldehydes ◽

Efficient Synthesis ◽

Atom Economy ◽

Short Reaction Time ◽

Biologically Relevant ◽

High Yields ◽

Organometallic Catalyst ◽

Work Up

Efficient synthesis of non-annulated 2-amino-4H-pyrans and 2-amino-8-oxo-4,8-dihydropyrano[3,2-b]pyran derivatives, which are biologically relevant heterocycles is achieved, utilizing a domino three-component reaction of ethyl acetoacetate or kojic acid with aromatic aldehydes and malononitrile catalyzed by Zn(L-proline)2 as reusable organometallic catalyst. The process exhibits high atom economy, short reaction time, simple work up, high yields and environmentally friendly nature. Excellent yields of the targeted molecules have been obtained.

Silica sulfuric acid magnetic nanoparticle: an efficient and ecofriendly catalyst for synthesis of spiro[2-amino-4H-pyran-oxindole]s

Canadian Journal of Chemistry ◽

10.1139/cjc-2014-0345 ◽

2015 ◽

Vol 93 (5) ◽

pp. 546-549 ◽

Cited By ~ 10

Author(s):

Ali Reza Karimi ◽

Meysam Sourinia ◽

Zeinab Dalirnasab ◽

Marzie Karimi

Keyword(s):

Sulfuric Acid ◽

Magnetic Nanoparticle ◽

Ultrasound Irradiation ◽

Significant Loss ◽

Silica Sulfuric Acid ◽

One Pot ◽

External Magnet ◽

The One ◽

Silica sulfuric acid magnetic nanoparticles efficiently catalyze the one-pot, three-component reaction of isatins and malononitrile with dimedone, 1,3-dimethylbarbituric acid or 4-hydroxycoumarin in EtOH–H2O to afford the corresponding spiro[2-amino-4H-pyran-oxindole] derivatives in high yields under ultrasound irradiation at 60 °C. The heterogeneous nanocatalyst could be recovered easily from the reaction mixture using an external magnet and reused many times without significant loss of its catalytic activity.

A Facile Synthesis of Polysubstituted Pyrroles by One-Pot Three-Component Reaction

E-Journal of Chemistry ◽

10.1155/2012/915861 ◽

2012 ◽

Vol 9 (4) ◽

pp. 2239-2244 ◽

Cited By ~ 5

Author(s):

Hossein Anaraki-Ardakani ◽

Maziar Noei ◽

Mina Karbalaei-Harofteh ◽

Shahab Zomorodbakhsh

Keyword(s):

Room Temperature ◽

Facile Synthesis ◽

One Pot ◽

Pyrrole Derivatives ◽

Dialkyl Acetylenedicarboxylates ◽

One Pot Synthesis ◽

High Yields ◽

Neutral Conditions

A new and efficient one-pot synthesis of polysubstituted pyrrole derivatives by three-component reaction between dialkyl acetylenedicarboxylates, triphenylphosphine, 2-aminopyridin derivatives in the presence of arylglyoxals is described. The reactions were performed in dichloromethane at room temperature and neutral conditions and afforded high yields of products.

Synthesis of novel N-functionalized 4-aryl-tetrahydrobiquinoline-2,5-(1H,3H)-diones via one-pot three-component reaction: a joint experimental and computational study

Canadian Journal of Chemistry ◽

10.1139/cjc-2017-0564 ◽

2018 ◽

Vol 96 (12) ◽

pp. 1071-1078

Author(s):

Vahideh Zadsirjan ◽

Sayyed Jalil Mahdizadeh ◽

Majid M. Heravi ◽

Masumeh Heydari

Keyword(s):

Density Functional Theory ◽

Density Functional ◽

Computational Study ◽

Reaction Pathway ◽

Deep Insight ◽

One Pot ◽

Functional Theory ◽

High Yields ◽

Mechanism Of The Reaction

A novel series of N-functionalized 4-aryl-tetrahydrobiquinoline-2,5-(1H,3H)-diones were synthesized in high yields by a one-pot three-component reaction involving 2-chloroquinoline-3-carbaldehydes, Meldrum’s acid, and enaminones (dimedone-based enaminones) in the presence of K2CO3 in CH3CN under reflux condition. To gain a deep insight on the mechanism of the reaction, an extensive series of quantum mechanics calculations in the framework of density functional theory (DFT) were carried out for supporting the suggested reaction pathway.

A Copper(I)-Mediated Tandem Three-Component Synthesis of 5-Allyl-1,2,3-triazoles

Synthesis ◽

10.1055/s-0039-1691506 ◽

2019 ◽

Vol 52 (05) ◽

pp. 744-754

Author(s):

Yoona Song ◽

Soyun Lee ◽

Palash Dutta ◽

Jae-Sang Ryu

Keyword(s):

Room Temperature ◽

Reaction Conditions ◽

One Pot ◽

A copper(I)-mediated tandem three-component reaction using alkynes, azides, allyl iodides, CuI and NaNH2 is developed. The reactions proceed smoothly at room temperature to afford 5-allyl-1,2,3-triazoles, which can be further converted into 1,2,3-triazole-fused tricyclic scaffolds. This method features an efficient one-pot cascade route using commercial alkynes and affords the corresponding 5-allyl-1,2,3-triazoles with high yields and good selectivity under mild reaction conditions.