The Twisted Side Chain of Antillatoxin is Important for Potent Toxicity: Total Synthesis and Biological Evaluation of Antillatoxin and Analogues

2009 ◽  
Vol 122 (2) ◽  
pp. 339-342 ◽  
Author(s):  
Ken Okura ◽  
Shigeru Matsuoka ◽  
Ryosuke Goto ◽  
Masayuki Inoue
Keyword(s):  
Total Synthesis ◽  
Biological Evaluation ◽  
Side Chain ◽  
Synthesis And Biological Evaluation

scholarly journals Xylochemical Synthesis and Biological Evaluation of Shancigusin C and Bletistrin G

Molecules ◽  
2021 ◽  
Vol 26 (11) ◽  
pp. 3224
Author(s):  
Leander Geske ◽  
Ulrich Kauhl ◽  
Mohamed E. M. Saeed ◽  
Anja Schüffler ◽  
Eckhard Thines ◽  
...  
Keyword(s):  
Total Synthesis ◽  
Biological Activities ◽  
Biological Evaluation ◽  
Aromatic Substitution ◽  
Substitution Reactions ◽  
Total Syntheses ◽  
Wittig Olefination ◽  
Starting Point ◽  
Perkin Reaction ◽  
Synthesis And Biological Evaluation

The biological activities of shancigusin C (1) and bletistrin G (2), natural products isolated from orchids, are reported along with their first total syntheses. The total synthesis of shancigusin C (1) was conducted by employing the Perkin reaction to forge the central stilbene core, whereas the synthesis of bletistrin G (2) was achieved by the Wittig olefination followed by several regioselective aromatic substitution reactions. Both syntheses were completed by applying only renewable starting materials according to the principles of xylochemistry. The cytotoxic properties of shancigusin C (1) and bletistrin G (2) against tumor cells suggest suitability as a starting point for further structural variation.

Total synthesis and biological evaluation of Wewakazole

2017 ◽  
Vol 33 (6) ◽  
pp. 890-894 ◽  
Author(s):  
Bohua Long ◽  
Jingzhao Zhang ◽  
Xueyan Wang ◽  
Xudong Tang ◽  
Zhengzhi Wu
Keyword(s):  
Total Synthesis ◽  
Biological Evaluation ◽  
Synthesis And Biological Evaluation

Total Synthesis and Biological Evaluation of Cortistatins A and J and Analogues Thereof

2009 ◽  
Vol 131 (30) ◽  
pp. 10587-10597 ◽  
Author(s):  
K. C. Nicolaou ◽  
Xiao-Shui Peng ◽  
Ya-Ping Sun ◽  
Damien Polet ◽  
Bin Zou ◽  
...  
Keyword(s):  
Total Synthesis ◽  
Biological Evaluation ◽  
Synthesis And Biological Evaluation

Identification of 2-arylquinazolines with alkyl-polyamine motifs as potent antileishmanial agents: Synthesis and biological evaluation studies

2022 ◽  
Author(s):  
Anjila Kumari ◽  
Tara Jaiswal ◽  
Vinay Kumar ◽  
Neha Hura ◽  
Gulshan Kumar ◽  
...  
Keyword(s):  
Evaluation Studies ◽  
Biological Evaluation ◽  
Side Chain ◽  
Chain Ring ◽  
Synthesis And Biological Evaluation

2-Arylquinazolines with a range of alkyl polyamines as side chain/ring functional motifs at 4th-position were considered for antileishmanial study with the rationale that related heterocyclic scaffolds and the polyamine functionalities...

scholarly journals Total Synthesis and Biological Evaluation of the Glycosylated Macrocyclic Antibiotic Mangrolide A

2018 ◽  
Vol 57 (34) ◽  
pp. 11020-11024 ◽  
Author(s):  
Hiromu Hattori ◽  
Joel Roesslein ◽  
Patrick Caspers ◽  
Katja Zerbe ◽  
Hideki Miyatake-Ondozabal ◽  
...  
Keyword(s):  
Total Synthesis ◽  
Biological Evaluation ◽  
Macrocyclic Antibiotic ◽  
Synthesis And Biological Evaluation

Total Synthesis and Biological Evaluation of (+)-Neopeltolide and Its Analogues

2009 ◽  
Vol 15 (46) ◽  
pp. 12807-12818 ◽  
Author(s):  
Haruhiko Fuwa ◽  
Asami Saito ◽  
Shinya Naito ◽  
Keiichi Konoki ◽  
Mari Yotsu-Yamashita ◽  
...  
Keyword(s):  
Total Synthesis ◽  
Biological Evaluation ◽  
Synthesis And Biological Evaluation
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