Cardiac neural crest contribution to the pulmonary artery and sixth aortic arch artery complex in chick embryos aged 6 to 18 days

1993 ◽  
Vol 237 (3) ◽  
pp. 385-399 ◽  
Author(s):  
Karen L. Waldo ◽  
Margaret L. Kirby
Keyword(s):  
Pulmonary Artery ◽  
Neural Crest ◽  
Aortic Arch ◽  
Chick Embryos ◽  
Cardiac Neural Crest

Abnormal histology of the aortic arch in coarctation of the aorta

1993 ◽  
Vol 3 (4) ◽  
pp. 412-416 ◽  
Author(s):  
Derk W. Wolterbeek ◽  
Arie P. Kappetein ◽  
Adriana C. Gittenberger–de Groot
Keyword(s):  
Neural Crest ◽  
Aortic Arch ◽  
Aortic Coarctation ◽  
Coarctation Of The Aorta ◽  
Lower Number ◽  
Descending Aorta ◽  
Aortic Isthmus ◽  
Cardiac Neural Crest ◽  
The Media

SummaryWe examined the number of elastic lamellae in the wall of the proximal aortic arch, aortic isthmus and descending aorta in patients with coarctation of the aorta. In the proximal aortic arch, the number of elastic lamellae was significantly lower in patients with coarctation compared to those with normal hearts without aortic anomalies and those with intracardiac defects but without aortic anomalies. The isthmus also showed a significantly lower number of elastic lamellae in the presence of preductal coarctation. In the descending aorta, the number of elastic lamellae was not significantly different between the different groups. There is doubt about the etiology of coarctation. Recent investigations showed that cells from the cardiac neural crest contribute to the formation of the arch arteries and the media of the arch. A developmental error of the neural crest might be responsible for the abnormal mural structures found in patients with aortic coarctation.

Transient cranial hemorrhage does not cause depressed contractility in cardiac neural crest-ablated chick embryos

Teratology ◽  
1997 ◽  
Vol 56 (5) ◽  
pp. 300-304 ◽  
Author(s):  
Amy D. Kirby ◽  
Raymond R. Wolfe ◽  
Maribeth Johnson ◽  
Linda Leatherbury ◽  
Margaret L. Kirby
Keyword(s):  
Neural Crest ◽  
Chick Embryos ◽  
Cardiac Neural Crest

scholarly journals Proteins Associated with Cardiac Neural Crest in the Pharyngeal Region of Early Chick Embryos

1993 ◽  
Vol 33 (1) ◽  
pp. 43-47 ◽  
Author(s):  
Ra-Id Abdulla ◽  
Edwin F Slott ◽  
Margaret L Kirby
Keyword(s):  
Neural Crest ◽  
Chick Embryos ◽  
Cardiac Neural Crest ◽  
Pharyngeal Region

Cardiac neural crest ablation inhibits compaction and electrical function of conduction system bundles

2007 ◽  
Vol 292 (3) ◽  
pp. H1291-H1300 ◽  
Author(s):  
Abhijit Gurjarpadhye ◽  
Kenneth W. Hewett ◽  
Charles Justus ◽  
Xuejun Wen ◽  
Harriett Stadt ◽  
...  
Keyword(s):  
Neural Crest ◽  
Conduction System ◽  
Lineage Tracing ◽  
Chick Embryos ◽  
Myocardial Cells ◽  
Cardiac Neural Crest ◽  
His Bundle ◽  
Electrical Connections ◽  
Migration Of Cells ◽  
Ventricular Conduction

Retroviral and transgenic lineage-tracing studies have shown that neural crest cells associate with the developing bundles of the ventricular conduction system. Whereas this migration of cells does not provide progenitors for the myocardial cells of the conduction system, the question of whether neural crest affects the differentiation and/or function of cardiac specialized tissues continues to be of interest. Using optical mapping of voltage-sensitive dye, we determined that ventricles from chick embryos in which the cardiac neural crest had been laser ablated did not progress to apex-to-base activation by the expected stage [i.e., Hamburger and Hamilton (HH) 35] but instead maintained basal breakthroughs of epicardial activation consistent with immature function of the conduction system. In direct studies of activation, waves of depolarization originating from the His bundle were found to be uncommon in control hearts from HH34 and HH35 embryos. However, activations propagating from septal base, at or near the His bundle, occurred frequently in hearts from HH34 and HH35 neural crest-ablated embryos. Consistent with His bundle cells maintaining electrical connections with adjacent working myocytes, histological analyses of hearts from neural crest-ablated embryos revealed His bundles that had not differentiated a lamellar organization or undergone a process of compaction and separation from surrounding myocardium observed in controls. Furthermore, measurements on histological sections from optically mapped hearts indicated that, whereas His bundle diameter in control embryos thinned by almost one-half between HH30 and HH34, the His bundle in ablated embryos underwent no such compaction in diameter, maintaining a thickness at HH30, HH32, and HH34 similar to that observed in HH30 controls. We conclude that the cardiac neural crest is required in a novel function involving lamellar compaction and electrical isolation of the basally located His bundle from surrounding myocardium.

Dilatation of the entire thoracic aorta in patients with bicuspid aortic valve: a magnetic resonance angiography study

VASA ◽  
2005 ◽  
Vol 34 (3) ◽  
pp. 181-185 ◽  
Author(s):  
Westhoff-Bleck ◽  
Meyer ◽  
Lotz ◽  
Tutarel ◽  
Weiss ◽  
...  
Keyword(s):  
Magnetic Resonance ◽  
Magnetic Resonance Angiography ◽  
Aortic Valve ◽  
Pulmonary Artery ◽  
Aortic Arch ◽  
Thoracic Aorta ◽  
Aortic Root ◽  
Ascending Aorta ◽  
Descending Aorta ◽  
Severe Aortic Regurgitation

Background: The presence of a bicuspid aortic valve (BAV) might be associated with a progressive dilatation of the aortic root and ascending aorta. However, involvement of the aortic arch and descending aorta has not yet been elucidated. Patients and methods: Magnetic resonance angiography (MRA) was used to assess the diameter of the ascending aorta, aortic arch, and descending aorta in 28 patients with bicuspid aortic valves (mean age 30 ± 9 years). Results: Patients with BAV, but without significant aortic stenosis or regurgitation (n = 10, mean age 27 ± 8 years, n.s. versus control) were compared with controls (n = 13, mean age 33 ± 10 years). In the BAV-patients, aortic root diameter was 35.1 ± 4.9 mm versus 28.9 ± 4.8 mm in the control group (p < 0.01). The diameter of the ascending aorta was also significantly increased at the level of the pulmonary artery (35.5 ± 5.6 mm versus 27.0 ± 4.8 mm, p < 0.001). BAV-patients with moderate or severe aortic regurgitation (n = 18, mean age 32 ± 9 years, n.s. versus control) had a significant dilatation of the aortic root, ascending aorta at the level of the pulmonary artery (41.7 ± 4.8 mm versus 27.0 ± 4.8 mm in control patients, p < 0.001) and, furthermore, significantly increased diameters of the aortic arch (27.1 ± 5.6 mm versus 21.5 ± 1.8 mm, p < 0.01) and descending aorta (21.8 ± 5.6 mm versus 17.0 ± 5.6 mm, p < 0.01). Conclusions: The whole thoracic aorta is abnormally dilated in patients with BAV, particularly in patients with moderate/severe aortic regurgitation. The maximum dilatation occurs in the ascending aorta at the level of the pulmonary artery. Thus, we suggest evaluation of the entire thoracic aorta in patients with BAV.

scholarly journals Salvage surgery for stage IVa thymic carcinoma combined with aortic arch resection – case report

2020 ◽  
Vol 15 (1) ◽  
Author(s):  
Hiroyuki Yamato ◽  
Soichiro Funaki ◽  
Kazuo Shimamura ◽  
Keiwa Kin ◽  
Toru Kuratani ◽  
...  
Keyword(s):  
Pulmonary Artery ◽  
Aortic Arch ◽  
Thymic Carcinoma ◽  
Salvage Surgery ◽  
Radical Resection ◽  
Left Pulmonary Artery ◽  
Aortic Arch Replacement ◽  
Extended Surgery ◽  
Malignant Pericardial Effusion ◽  
Increased Risk

Abstract Background Although complete surgical resection of thymic carcinoma is a prognostic factor, extended surgery combined with a major blood vessel procedure remains controversial because of the increased risk of mortality. We report a case of Stage IVa thymic carcinoma successfully resected with a pneumonectomy along with aortic arch replacement after chemotherapy. Case presentation A 45-year-old male was diagnosed with thymic carcinoma invasion to the aortic arch and left pulmonary artery. Malignant pericardial effusion was also noted, though disappeared after chemotherapy, thus surgical options were considered. A radical resection procedure including left pneumonectomy, aortic arch replacement with total rerouting of the supra-arch vessels, and right pulmonary artery plication was performed. The postoperative course was uneventful and the patient has been disease-free for 3 years. Conclusion Extended salvage surgery might be a valuable option for advanced thymic carcinoma.

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