Diabetic Basement Membrane Thickening Does Not Occur in Myocardial Capillaries of Transgenic Mice When Metallothionein is Overexpressed in Cardiac Myocytes

2013 ◽  
Vol 296 (3) ◽  
pp. 480-487 ◽  
Author(s):  
ANA Velic ◽  
Donna Laturnus ◽  
Jennifer Chhoun ◽  
Shirong Zheng ◽  
Paul Epstein ◽  
...  
Keyword(s):  
Basement Membrane ◽  
Transgenic Mice ◽  
Cardiac Myocytes ◽  
Basement Membrane Thickening

Basement membrane thickening in cardiac myocytes and capillaries in chronic Chagas' disease

1988 ◽  
Vol 61 (13) ◽  
pp. 1137-1140 ◽  
Author(s):  
Victor J. Ferrans ◽  
Jose Milei ◽  
Yoshifumi Tomita ◽  
Ruben A. Storino
Keyword(s):  
Basement Membrane ◽  
Cardiac Myocytes ◽  
Chagas Disease ◽  
Basement Membrane Thickening ◽  
Chronic Chagas Disease

Cardiac myocytes cultured on a basement membrane extract of the ehs tumor

1986 ◽  
Vol 44 ◽  
pp. 270-271
Author(s):  
L. Terracio ◽  
A. Dewey ◽  
K. Rubin ◽  
T.K. Borg
Keyword(s):  
Extracellular Matrix ◽  
Basement Membrane ◽  
Cardiac Myocytes ◽  
Normal Tissue ◽  
Cell Spreading ◽  
Collagen Iv ◽  
Basement Membrane Extract ◽  
Membrane Extract ◽  
Growth Development ◽  
Multicellular Organisms

The recognition and interaction of cells with the extracellular matrix (ECM) effects the normal physiology as well as the pathology of all multicellular organisms. These interactions have been shown to influence the growth, development, and maintenance of normal tissue function. In previous studies, we have shown that neonatal cardiac myocytes specifically interacts with a variety of ECM components including fibronectin, laminin, and collagens I, III and IV. Culturing neonatal myocytes on laminin and collagen IV induces an increased rate of both cell spreading and sarcomerogenesis.

scholarly journals Apoptosis of Cardiac Myocytes in Gsα Transgenic Mice

1999 ◽  
Vol 84 (1) ◽  
pp. 34-42 ◽  
Author(s):  
Yong-Jian Geng ◽  
Yoshihiro Ishikawa ◽  
Dorothy E. Vatner ◽  
Thomas E. Wagner ◽  
Sanford P. Bishop ◽  
...  
Keyword(s):  
Transgenic Mice ◽  
Cardiac Myocytes

Microalbuminuria and Capillary Basement Membrane Thickening in Diabetic Peripheral Neuropathy

1986 ◽  
Vol 70 (s13) ◽  
pp. 73P-73P
Author(s):  
P.E. Jennings ◽  
N. Lawson ◽  
P. Hoffman ◽  
J.R. Williamson ◽  
A.H. Barnett
Keyword(s):  
Peripheral Neuropathy ◽  
Basement Membrane ◽  
Diabetic Peripheral Neuropathy ◽  
Capillary Basement Membrane ◽  
Basement Membrane Thickening

Basement Membrane Thickening in Latent Diabetes

1973 ◽  
pp. 393-399 ◽  
Author(s):  
Stefan S. Fajans ◽  
Joseph R. Williamson ◽  
Peter N. Weissman ◽  
Nancy J. Vogler ◽  
Charles Kilo ◽  
...  
Keyword(s):  
Basement Membrane ◽  
Latent Diabetes ◽  
Basement Membrane Thickening

C-myc protooncogene modulates cardiac hypertrophic growth in transgenic mice

1992 ◽  
Vol 262 (2) ◽  
pp. H590-H597 ◽  
Author(s):  
R. J. Robbins ◽  
J. L. Swain
Keyword(s):  
Transgenic Mice ◽  
Cardiac Myocytes ◽  
Cardiac Myocyte ◽  
Fold Increase ◽  
Cardiac Mass ◽  
Hypertrophic Growth ◽  
Basal Expression ◽  
Pharmacological Stimulation ◽  
Beta Adrenergic Agonist

Protooncogenes such as c-myc have been implicated in the transduction of growth signals in the cardiac myocyte. We examined whether increases in c-myc expression occur in murine heart in vivo as a generalized response to the pharmacological stimulation of myocyte growth. Both triiodothyronine (T3) and the beta-adrenergic agonist isoproterenol were demonstrated to induce a rapid and transient increase in cardiac c-myc mRNA abundance, which preceded an increase in cardiac mass. We then examined whether myocyte growth could be modulated by selectively altering cardiac c-myc expression. The model system used was a strain of transgenic mice exhibiting a 20-fold increase in cardiac c-myc expression. Although in nontransgenic mice the administration of T3 and isoproterenol resulted in similar increases in cardiac mass, in transgenic mice the degree of myocardial growth induced with T3 was significantly greater than that induced with isoproterenol (P less than 0.001). This study demonstrates that increasing the basal expression of c-myc in cardiac myocytes alters the growth response of the heart in vivo to certain hypertrophic stimuli and implicates the c-myc protooncogene in the transduction of selective hypertrophic growth signals in differentiated cardiac myocytes.

scholarly journals Enalapril retards glomerular basement membrane thickening and albuminuria in the diabetic rat

Diabetologia ◽  
1989 ◽  
Vol 32 (5) ◽  
pp. 326-328 ◽  
Author(s):  
M. E. Cooper ◽  
T. J. Allen ◽  
P. A. Macmillan ◽  
B. E. Clarke ◽  
G. Jerums ◽  
...  
Keyword(s):  
Basement Membrane ◽  
Glomerular Basement Membrane ◽  
Diabetic Rat ◽  
Basement Membrane Thickening ◽  
Glomerular Basement Membrane Thickening
Sign in / Sign up

Export Citation Format

Share Document