Functional analysis of the odorant receptor coreceptor in odor detection in Grapholita molesta (lepidoptera: Tortricidae)

2021 ◽  
Author(s):  
Xiu‐Lin Chen ◽  
Bo‐Liao Li ◽  
Yu‐Xin Chen ◽  
Guang‐Wei Li ◽  
Jun‐Xiang Wu
Keyword(s):  
Functional Analysis ◽  
Odorant Receptor ◽  
Grapholita Molesta ◽  
Odor Detection

scholarly journals Functional Analysis of the Chemosensory Protein GmolCSP8 From the Oriental Fruit Moth, Grapholita molesta (Busck) (Lepidoptera: Tortricidae)

2019 ◽  
Vol 10 ◽  
Author(s):  
Guang-Wei Li ◽  
Xiu-Lin Chen ◽  
Li-Hui Chen ◽  
Wen-Qiang Wang ◽  
Jun-Xiang Wu
Keyword(s):  
Functional Analysis ◽  
Oriental Fruit Moth ◽  
Grapholita Molesta ◽  
Chemosensory Protein

scholarly journals Single olfactory receptors set odor detection thresholds

2018 ◽  
Author(s):  
Adam Dewan ◽  
Annika Cichy ◽  
Jingji Zhang ◽  
Kayla Miguel ◽  
Paul Feinstein ◽  
...  
Keyword(s):  
Sensory Neurons ◽  
Odorant Receptor ◽  
Olfactory Receptors ◽  
Detection Thresholds ◽  
Behavioral Threshold ◽  
Odor Detection ◽  
Biologically Relevant ◽  
Species Survival ◽  
Highly Sensitive ◽  
Behavioral Sensitivity

ABSTRACTIn many species, survival depends on olfaction, yet the mechanisms that underlie olfactory sensitivity are not well understood. Here, we examine how a conserved subset of olfactory receptors, the trace amine-associated receptors (TAARs) determine odor detection thresholds of mice to amines. We find that deleting all TAARs, or even single TAARs, results in significant odor detection deficits. This finding is not limited to TAARs, as the deletion of a canonical odorant receptor reduced behavioral sensitivity to its preferred ligand. Remarkably, behavioral threshold is set solely by the most sensitive receptor, with no contribution from other highly sensitive receptors. In addition, increasing the number of sensory neurons (and glomeruli) expressing a threshold-determining TAAR does not improve detection, indicating that sensitivity is not limited by the typical complement of sensory neurons. Our findings demonstrate that olfactory thresholds are set by the single highest affinity receptor, and suggest that TAARs are evolutionarily conserved because they determine the sensitivity to a class of biologically relevant chemicals.

scholarly journals Odor coding in the mammalian olfactory epithelium

2021 ◽  
Author(s):  
Smija M. Kurian ◽  
Rafaella G. Naressi ◽  
Diogo Manoel ◽  
Ann-Sophie Barwich ◽  
Bettina Malnic ◽  
...  
Keyword(s):  
Sensory Neurons ◽  
Olfactory Epithelium ◽  
New Technologies ◽  
Odorant Receptor ◽  
Olfactory Mucosa ◽  
Odorant Receptors ◽  
Odor Coding ◽  
New Era ◽  
Odor Detection ◽  
Receptor Interactions

AbstractNoses are extremely sophisticated chemical detectors allowing animals to use scents to interpret and navigate their environments. Odor detection starts with the activation of odorant receptors (ORs), expressed in mature olfactory sensory neurons (OSNs) populating the olfactory mucosa. Different odorants, or different concentrations of the same odorant, activate unique ensembles of ORs. This mechanism of combinatorial receptor coding provided a possible explanation as to why different odorants are perceived as having distinct odors. Aided by new technologies, several recent studies have found that antagonist interactions also play an important role in the formation of the combinatorial receptor code. These findings mark the start of a new era in the study of odorant-receptor interactions and add a new level of complexity to odor coding in mammals.

scholarly journals Odor Coding in the Mammalian Olfactory Epithelium

2020 ◽  
Author(s):  
Smija M. Kurian ◽  
Rafaella G. Naressi ◽  
Diogo Manoel ◽  
Ann-Sophie Barwich ◽  
Bettina Malnic ◽  
...  
Keyword(s):  
Sensory Neurons ◽  
Olfactory Epithelium ◽  
New Technologies ◽  
Odorant Receptor ◽  
Olfactory Mucosa ◽  
Odorant Receptors ◽  
Odor Coding ◽  
New Era ◽  
Odor Detection ◽  
Receptor Interactions

Noses are extremely sophisticated chemical detectors allowing animals to use scents to interpret and navigate their environments. Odor detection starts with the activation of odorant receptors (ORs), expressed in mature olfactory sensory neurons (OSNs) populating the olfactory mucosa. Different odorants, or different concentrations of the same odorant, activate unique ensembles of ORs. This mechanism of combinatorial receptor coding provided a possible explanation as to why different odorants are perceived as having distinct odors. Aided by new technologies, several recent studies have found that antagonist interactions also play an important role in the formation of the combinatorial receptor code. These findings mark the start of a new era in the study of odorant-receptor interactions and add a new level of complexity to odor coding in mammals.

scholarly journals Functional analysis of a mammalian odorant receptor subfamily

2006 ◽  
Vol 97 (5) ◽  
pp. 1506-1518 ◽  
Author(s):  
Tatjana Abaffy ◽  
Hiroaki Matsunami ◽  
Charles W. Luetje
Keyword(s):  
Functional Analysis ◽  
Odorant Receptor

The general odorant receptor GmolOR9 from Grapholita molesta (Lepidoptera: Tortricidae) is mainly tuned to eight host‐plant volatiles

2019 ◽  
Vol 27 (6) ◽  
pp. 1233-1243 ◽  
Author(s):  
Li‐Hui Chen ◽  
Ke Tian ◽  
Gui‐Rong Wang ◽  
Xiang‐Li Xu ◽  
Ke‐Hang He ◽  
...  
Keyword(s):  
Host Plant ◽  
Plant Volatiles ◽  
Odorant Receptor ◽  
Host Plant Volatiles ◽  
Grapholita Molesta
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