Technology Leadership In Malaysian Schools- The Way Forward To Education 4.0

Education 4.0 is the answer to the global needs for the advanced integration of humans and technology. Leading school’s technology utilization can be the way forward to support education 4.0 realization. This study aims to investigate the effects and roles of principals’ technology leadership towards teachers’ ICT utilization and students’ academic performance in secondary schools in Selangor, Malaysia. This empirical study uses a set of questionnaires to gather information from respondents who are in the teaching profession. A total of 310 questionnaires were completed and analyzed. The findings have shown significant positive impacts between the effects of the technology leadership roles of principals on teachers’ effective ICT utilization and students’ academic performance. The integration of ICT and technological tools in schools has a great challenge towards the new era of the Education 4.0 system. This suggests that principals who embrace technology will effectively lead their schools to acquire educational resources to enhance student engagement and learning.

Perkembangan Ekspor dan Impor Sumatera Utara pada Tatanan Hidup Baru

The level of a province can be seen from its economic growth, seen from the aspect of the value of exports and imports which have an influence on a trade between provinces. After the occurrence of covid-19 which had a major impact on Indonesian trade and the global economy. As a result of the pandemic, there have been major changes in world trade patterns, such as the lockdown system implemented in Indonesia. This study aims to determine the development of exports and imports of North Sumatra Province through indicators of export and import values. The data analysis technique in this research is descriptive data analysis. The source of data in this study is secondary data taken in (2016/2020) which is downloaded via www.bps.go.id, especially export and import data during the development of a new economic life order in North Sumatra Province. The results show that there is an increase that can be seen from the increase in the volume and value of imports and exports in a province, a decrease in the volume and value of imports and exports of imports, the development of a new economic order of life. With good economic growth, it will increase national income, the community will be prosperous in terms of the economy. In the last decade, exports continued to increase in 2021 to reach Rp. 13 trillion. Many studies have stated that in the past year, export-import cases have fluctuated during the COVID-19 period. And this pandemic has taught us the need to encourage export and import diversification, diversification of supplying countries and product destinations. produced in order to develop in a new life order. Keywords: Export, Import, New Era, Economic Growth

The New Voice for the New Era of Thalassemia Reports

The recent transfer of Thalassemia Reports, the only journal fully dedicated on Thalassemia, from PagePress to MDPI was great news for those who contributed to the spread of the journal [...]

Proteomics: a new era in pediatric acute myeloid leukemia research

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Research on a Good Life and Coordinated Development Based on Intelligent Communication and k-Means Algorithm

Due to the rapid development of society and economy, people have more and more urgent needs for a better life and coordinated development between regions. However, research on people’s good life and coordinated development based on new era technologies such as intelligent communication is not sufficient. The future of smart communications technology will be all over the place, from television to mobile phones and the Internet, and ICT is making the world look new, helping hundreds of millions of people to live, work, and play in the most creative ways. At the same time, ICT is managing cities in innovative ways, especially in an increasingly integrated information society, exchanging information knowledge and communicating on the move. In order to understand the impact of intelligent communication on people’s good life and coordinated development research, this paper uses intelligent communication and k-means algorithm-based methods to study people’s good life and coordinated development and conducts questionnaire surveys and constructs corresponding evaluation indicators analysis. The results showed that 36% of the respondents were satisfied with the housing environment, 24% were relatively satisfied, 76% were satisfied with the greening environment, and 13% were relatively satisfied. 41% of people are satisfied with their health, and 32% are satisfied with their work status. This shows that people’s good life and coordinated development are inseparable from rapid economic development, but rapid economic development alone is far from enough because rapid economic development can improve people’s material living conditions, but not necessarily promote people’s life coordination in the spiritual world. Therefore, for people’s good life and coordinated development, the improvement of material economy and the construction of spiritual level are indispensable.

Potential Application of Bionanoparticles to Treat Severe Acute Respiratory Syndrome Coronavirus-2 Infection

Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is a contagious virus that spreads exponentially across the world, resulting in serious viral pneumonia. Several companies and researchers have put their tremendous effort into developing novel vaccines or drugs for the complete eradication of COVID-19 caused by SARS-CoV-2. Bionanotechnology plays a vital role in designing functionalized biocompatible nanoparticulate systems with higher antiviral capabilities. Thus, several nanocarriers have been explored in designing and delivering drugs and vaccines. This problem can be overcome with the intervention of biomaterials or bionanoparticles. The present review describes the comparative analysis of SARS infection and its associated etiological agents. This review also highlighted some nanoparticles that have been explored in the treatment of COVID-19. However, these carriers elicit several problems once they come in contact with biological systems. Often, the body’s immune system treats these nanocarriers as foreign particles and antigens. In contrast, some bionanoparticles are highlighted here with their potential application in SARS-CoV-2. However, bionanoparticles have demonstrated some drawbacks discussed here with the possible outcomes. The scope of bioinspired nanoparticles is also discussed in detail to explore the new era of research. It is highly essential for the effective delivery of these nanoparticles to the target site. For effective management of SARS-CoV-2, different delivery patterns are also discussed here.

The crystal structure of vaccinia virus protein E2 and perspectives on the prediction of novel viral protein folds

The morphogenesis of vaccinia virus (VACV, family Poxviridae), the smallpox vaccine, is a complex process involving multiple distinct cellular membranes and resulting in multiple different forms of infectious virion. Efficient release of enveloped virions, which promote systemic spread of infection within hosts, requires the VACV protein E2 but the molecular basis of E2 function remains unclear and E2 lacks sequence homology to any well-characterised family of proteins. We solved the crystal structure of VACV E2 to 2.3 Å resolution, revealing that it comprises two domains with novel folds: an N-terminal annular (ring) domain and a C-terminal globular (head) domain. The C-terminal head domain displays weak structural homology with cellular (pseudo)kinases but lacks conserved surface residues or kinase features, suggesting that it is not enzymatically active, and possesses a large surface basic patch that might interact with phosphoinositide lipid headgroups. Recent deep learning methods have revolutionised our ability to predict the three-dimensional structures of proteins from primary sequence alone. VACV E2 is an exemplar ‘difficult’ viral protein target for structure prediction, being comprised of multiple novel domains and lacking sequence homologues outside Poxviridae. AlphaFold2 nonetheless succeeds in predicting the structures of the head and ring domains with high and moderate accuracy, respectively, allowing accurate inference of multiple structural properties. The advent of highly accurate virus structure prediction marks a step-change in structural virology and beckons a new era of structurally-informed molecular virology.