No developmental toxicity observed with dolutegravir in rat whole embryo culture

2021 ◽  
Author(s):  
Lorraine M. Posobiec ◽  
Sharon P. Chapman ◽  
Stacia F. Murzyn ◽  
Joyce E. Rendemonti ◽  
Dinesh J. Stanislaus ◽  
...  
Keyword(s):  
Embryo Culture ◽  
Developmental Toxicity ◽  
Whole Embryo Culture

Developmental toxicity of formate and formic acid in whole embryo culture: A comparative study with mouse and rat embryos

Teratology ◽  
1995 ◽  
Vol 51 (4) ◽  
pp. 243-251 ◽  
Author(s):  
James E. Andrews ◽  
Marian Ebron-McCoy ◽  
Robert J. Kavlock ◽  
John M. Rogers
Keyword(s):  
Comparative Study ◽  
Formic Acid ◽  
Embryo Culture ◽  
Developmental Toxicity ◽  
Whole Embryo Culture ◽  
Rat Embryos

Developmental toxicity of methanol: Pathogenesis in CD-1 and C57BL/6J mice exposed in whole embryo culture

2004 ◽  
Vol 70 (4) ◽  
pp. 179-184 ◽  
Author(s):  
Sigmund J. Degitz ◽  
John M. Rogers ◽  
Robert M. Zucker ◽  
E. Sidney Hunter
Keyword(s):  
Embryo Culture ◽  
Developmental Toxicity ◽  
Whole Embryo Culture

scholarly journals Exogenous Nucleotides Antagonize the Developmental Toxicity of EthanolIn Vitro

2013 ◽  
Vol 2013 ◽  
pp. 1-8
Author(s):  
Jie Zhao ◽  
Jia-Xi Zhao ◽  
Ya-Jun Xu
Keyword(s):  
Birth Defects ◽  
Embryo Culture ◽  
Culture System ◽  
Growth Parameters ◽  
Developmental Toxicity ◽  
Micromass Culture ◽  
Protective Effects ◽  
Whole Embryo Culture ◽  
Proliferation And Differentiation

The objective of this study was to assess whether nucleotides supplementationin vitrocould suppress ethanol-induced developmental toxicity in mouse. The models of whole embryo culture (WEC) and midbrain (MB) cell micromass culture were used in this study. In WEC system, exposure to 4.0 mg/mL ethanol for 48 h yielded various developmental malformations of the mice embryos. Nucleotides supplementation (0.16, 0.80, 4.00, 20.00, and 100.00 mg/L) improved the growth parameters to some extent, and the protective effects peaked at 4.00 mg/L. In MB cell micromass culture system, exposure to 4.0 mg/mL ethanol for 5 days resulted in suppression of proliferation and differentiation. Supplementation of nucleotides (0.16, 0.80, 4.00, 20.00, and 100.00 mg/L) showed some protective effects, which peaked at 4.00 mg/L, too. The present research indicated that nucleotides supplementation might be of some benefit in the prevention of ethanol-induced birth defects; however, appropriate dosage requires attention.

Identification of molecular biomarkers for screening the mechanism of azoles’ developmental toxicity in the rat Whole Embryo Culture

2016 ◽  
Vol 64 ◽  
pp. 19
Author(s):  
Myrto Dimopoulou ◽  
Aart Verhoef ◽  
Bennard van Ravenzwaay ◽  
Ivonne M.C.M. Rietjens ◽  
Aldert H. Piersma
Keyword(s):  
Embryo Culture ◽  
Developmental Toxicity ◽  
Molecular Biomarkers ◽  
Whole Embryo Culture

Evaluation of the developmental toxicity of citrinin using Hydra attenuata and postimplantation rat whole embryo culture

Toxicology ◽  
1993 ◽  
Vol 85 (2-3) ◽  
pp. 179-198 ◽  
Author(s):  
Yung Gung Yang ◽  
Kittane Mayura ◽  
Charles Barton Spainhour ◽  
John Francis Edwards ◽  
Timothy Dukes Phillips
Keyword(s):  
Embryo Culture ◽  
Developmental Toxicity ◽  
Whole Embryo Culture ◽  
Hydra Attenuata
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