Application of a lanthanide composite nanoparticle-sensitized luminescence method for the determination of salicylic acid in pharmaceutical formulations and human plasma

Luminescence ◽  
2008 ◽  
Vol 23 (6) ◽  
pp. 417-423 ◽  
Author(s):  
Mohammad Mainul Karim ◽  
Seikh Mafiz Alam ◽  
Sang Hak Lee
Keyword(s):  
Salicylic Acid ◽  
Human Plasma ◽  
Pharmaceutical Formulations ◽  
Luminescence Method ◽  
Sensitized Luminescence ◽  
Composite Nanoparticle

Sensitive enantioseparation and determination of isoprenaline in human plasma and pharmaceutical formulations

2019 ◽  
pp. e4550 ◽  
Author(s):  
Vinod Kumar Vashistha ◽  
Ravi Bhushan
Keyword(s):  
Human Plasma ◽  
Pharmaceutical Formulations

scholarly journals Spectrofluorometric Determination of Verapamil Hydrochloride in Pharmaceutical Preparations and Human Plasma Using Organized Media: Application to Stability Studies

2006 ◽  
Vol 89 (6) ◽  
pp. 1565-1572 ◽  
Author(s):  
Mohamed Walash ◽  
Fathalla Belal ◽  
Nahed El-Enany ◽  
Amina Abdelsalam
Keyword(s):  
Human Plasma ◽  
Biological Fluids ◽  
Sodium Dodecyl ◽  
Pharmaceutical Preparations ◽  
Pharmaceutical Formulations ◽  
Official Method ◽  
Stability Studies ◽  
Verapamil Hydrochloride ◽  
Spiked Human Plasma

Abstract A highly sensitive spectrofluorometric method was developed for the determination of verapamil hydrochloride (VP HCl) in pharmaceutical formulations and biological fluids. The proposed method is based on investigation of the fluorescence spectral behavior of VP HCl in micellar systems, such as sodium dodecyl sulfate (SDS) and β-cyclodextrin (β-CD). In aqueous solutions of borate buffer of pH 9 and 8.5, VP HCl was well incorporated into SDS and β-CD, respectively, with enhancement of its native fluorescence. The fluorescence was measured at 318 nm after excitation at 231 nm. The fluorescence intensity enhancements were 183 and 107% in SDS and in β-CD, respectively. The fluorescence-concentration plots were rectilinear over the range of 0.020.2 and 0.020.25 μg/mL, with lower detection limits of 5.58 × 103 and 3.62 × 103 μg/mL in SDS and β-CD, respectively. The method was successfully applied to the analysis of commercial tablets and the results were in good agreement with those obtained with the official method. The method was further applied to the determination of VP HCl in real and spiked human plasma. The mean % recoveries in the case of spiked human plasma (n 4) was 92.59 3.11 and 88.35 2.55 using SDS and β-CD, respectively, while that in real human plasma (n 3) was 90.17 6.93 and 89.17 6.50 using SDS and β-CD, respectively. The application of the method was extended to the stability studies of VP HCl after exposureto ultraviolet radiation and upon oxidation with hydrogen peroxide.

scholarly journals Terbium sensitized luminescence for the determination of fexofenadine in pharmaceutical formulations

2019 ◽  
Vol 12 (8) ◽  
pp. 2457-2463 ◽  
Author(s):  
Salma M.Z. Al-Kindy ◽  
Khadija Al-Shamalani ◽  
FakhrEldin O. Suliman ◽  
Haidar A.J. Al-Lawati
Keyword(s):  
Pharmaceutical Formulations ◽  
Sensitized Luminescence

Determination of Pantoprazole in Pharmaceutical Formulations and Human Plasma by Square‐Wave Voltammetry

2005 ◽  
Vol 38 (9) ◽  
pp. 1389-1404 ◽  
Author(s):  
Sacide Altınöz ◽  
Incilay Süslü
Keyword(s):  
Human Plasma ◽  
Square Wave Voltammetry ◽  
Pharmaceutical Formulations ◽  
Square Wave ◽  
Wave Voltammetry

scholarly journals A Terbium Sensitized Luminescence Method for the Assay of Flubiprofen in Pharmaceutical Formulations

2014 ◽  
Vol 19 (1) ◽  
pp. 54
Author(s):  
Salma M.Z. Al-Kindy ◽  
Arwa Al-Ghazali ◽  
Fakhr Eldin O. Suliman ◽  
Haidar A.J. Al-Lawati
Keyword(s):  
Limit Of Detection ◽  
Tap Water ◽  
Pharmaceutical Formulations ◽  
Aqueous System ◽  
Tween 20 ◽  
Luminescence Method ◽  
Time Resolved ◽  
Relative Standard ◽  
Excellent Reproducibility

A sensitive time-resolved luminescence method for the determination of flubiprofen (FLP) in methanol and in aqueous solution is described. The method is based on the luminescence sensitization of terbium (Tb3+ ) by the formation of a ternary complex with FLP in the presence of 4,7 diphenyl 1,10 phenanthroline (DPP) as co-ligand, and Tween-20 as surfactant. The signal for Tb-FLP-DPP was monitored at λex  = 285 nm and λem  = 552 nm. Optimum conditions for the formation of the complex in an aqueous system were TRIS buffer, pH 8.0, DPP (2.5Å~10−7  M), Tween-20 (0.30%) and 4Å~10-5  mol L-1  of Tb3+  which allowed the determination of 20–1000 ng mL-1  of FLP with a limit of detection (LOD) of 10 ng mL-1 . The relative standard deviations of the method ranged between 0.6 and 1.4% indicating excellent reproducibility of the method. The proposed method was successfully applied for the assays of FLP in pharmaceutical formulations and spiked tap water samples with average recoveries of 87% – 95%. 

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