Background:
Post-transplant Lymphopoliferative disorders(PTLD) are a well known late complication after solid organ
transplantation including renal transplant. Among others, graft failure due to reactivation of BK polyoma virus in the grafted kidney is
also a well recognized complication but tends to present early in the first several months after transplant.
Case:
Here we present the case of PTLD Burkitt's lymphoma(BL-PTLD) in a renal transplant patient who was successfully treated
with multiagent chemo-immunotherapy but later developed BK polyoma virus nephropathy(BKVN) with graft failure only after completion of her systemic therapy for lymphoma and 7 years after transplant. Relevant literature is reviewed.
Conclusion:
In this case, reactivation and progression of BKVN was most likely associated with immunosuppression from chemoimmunotherapy for her BL–PTLD unlike early graft failures associated with BKVN.
