Characterization of the G-quadruplex structure of a catalytic DNA with peroxidase activity

Biopolymers ◽  
2009 ◽  
Vol 91 (5) ◽  
pp. 331-339 ◽  
Author(s):  
De-Ming Kong ◽  
Li-Li Cai ◽  
Jun-Hong Guo ◽  
Jing Wu ◽  
Han-Xi Shen
Keyword(s):  
Peroxidase Activity ◽  
Quadruplex Structure ◽  
G Quadruplex ◽  
Catalytic Dna

scholarly journals In Silico Screening and Binding Characterization of Small Molecules toward a G-Quadruplex Structure Formed in the Promoter Region ofc-MYCOncogene

ACS Omega ◽  
2017 ◽  
Vol 2 (8) ◽  
pp. 4382-4397 ◽  
Author(s):  
Jyotsna Bhat ◽  
Soma Mondal ◽  
Pallabi Sengupta ◽  
Subhrangsu Chatterjee
Keyword(s):  
Small Molecules ◽  
In Silico ◽  
Promoter Region ◽  
In Silico Screening ◽  
Quadruplex Structure ◽  
G Quadruplex

Characterization of intermolecular G-quadruplex formation over intramolecular G-triplex for DNA containing three G-tracts

The Analyst ◽  
2020 ◽  
Vol 145 (12) ◽  
pp. 4254-4259
Author(s):  
Qingqing Zhang ◽  
Tong Yang ◽  
Guoxiang Zheng ◽  
Heng Gao ◽  
Chenxiao Yan ◽  
...  
Keyword(s):  
Quadruplex Structure ◽  
G Quadruplex ◽  
Quadruplex Formation

A guanine-rich sequence containing three G-tracts adopts a tetramolecular G-quadruplex structure (4erG4) rather than G-triplex (G3) folding.

Characterization of Insulin Ilpr Sequences for Their Ability to Adopt a G-Quadruplex Structure

2010 ◽  
Vol 29 (2) ◽  
pp. 81-90 ◽  
Author(s):  
Hanumantharao Paritala ◽  
Steven M. Firestine
Keyword(s):  
Quadruplex Structure ◽  
G Quadruplex

scholarly journals Radical cation transfer in a guanine pair: an insight to the G-quadruplex structure role using constrained DFT/MM

2021 ◽  
Vol 140 (7) ◽  
Author(s):  
Ranjitha Ravindranath ◽  
Padmabati Mondal ◽  
Natacha Gillet
Keyword(s):  
Radical Cation ◽  
Quadruplex Structure ◽  
G Quadruplex

scholarly journals DNA G-quadruplexes for native mass spectrometry in potassium: a database of validated structures in electrospray-compatible conditions

2021 ◽  
Author(s):  
Anirban Ghosh ◽  
Eric Largy ◽  
Valérie Gabelica
Keyword(s):  
Mass Spectrometry ◽  
Drug Targets ◽  
Native Mass Spectrometry ◽  
Drug Binding ◽  
Quadruplex Dna ◽  
Dna Structures ◽  
Nmr Structures ◽  
G Quadruplex ◽  
Screening Assays

Abstract G-quadruplex DNA structures have become attractive drug targets, and native mass spectrometry can provide detailed characterization of drug binding stoichiometry and affinity, potentially at high throughput. However, the G-quadruplex DNA polymorphism poses problems for interpreting ligand screening assays. In order to establish standardized MS-based screening assays, we studied 28 sequences with documented NMR structures in (usually ∼100 mM) potassium, and report here their circular dichroism (CD), melting temperature (Tm), NMR spectra and electrospray mass spectra in 1 mM KCl/100 mM trimethylammonium acetate. Based on these results, we make a short-list of sequences that adopt the same structure in the MS assay as reported by NMR, and provide recommendations on using them for MS-based assays. We also built an R-based open-source application to build and consult a database, wherein further sequences can be incorporated in the future. The application handles automatically most of the data processing, and allows generating custom figures and reports. The database is included in the g4dbr package (https://github.com/EricLarG4/g4dbr) and can be explored online (https://ericlarg4.github.io/G4_database.html).

scholarly journals Characterization of a stellate cell activation-associated protein (STAP) with peroxidase activity found in rat hepatic stellate cells.

2001 ◽  
Vol 276 (50) ◽  
pp. 47744
Author(s):  
Norifumi Kawada ◽  
Dan Bach Kristensen ◽  
Kinji Asahina ◽  
Kazuki Nakatani ◽  
Yukiko Minamiyama ◽  
...  
Keyword(s):  
Peroxidase Activity ◽  
Hepatic Stellate Cells ◽  
Cell Activation ◽  
Stellate Cell ◽  
Stellate Cells

Characterization of Heme–DNA Complexes Composed of Some Chemically Modified Hemes and Parallel G-Quadruplex DNAs

Biochemistry ◽  
2015 ◽  
Vol 54 (49) ◽  
pp. 7168-7177 ◽  
Author(s):  
Yasuhiko Yamamoto ◽  
Masashi Kinoshita ◽  
Yuya Katahira ◽  
Haruna Shimizu ◽  
Yue Di ◽  
...  
Keyword(s):  
Dna Complexes ◽  
Chemically Modified ◽  
G Quadruplex
Sign in / Sign up

Export Citation Format

Share Document