A rapid and simple RP-HPLC method for quantification of kirenol in rat plasma after oral administration and its application to pharmacokinetic study

2010 ◽  
Vol 25 (5) ◽  
pp. 542-546 ◽  
Author(s):  
Xiao-Li Song ◽  
Qing-Ying Zhang ◽  
Zhe-Ming Wang ◽  
Hong-Zheng Fu ◽  
Rui-Qin Qian
Keyword(s):  
Oral Administration ◽  
Pharmacokinetic Study ◽  
Rat Plasma ◽  
Hplc Method ◽  
Rp Hplc

scholarly journals Simultaneous Determination and Pharmacokinetic Comparisons of Multi-Ingredients after Oral Administration ofRadix Salviae MiltiorrhizaeExtract, Hawthorn Extract, and a Combination of Both Extracts to Rats

2014 ◽  
Vol 2014 ◽  
pp. 1-9 ◽  
Author(s):  
Yu-Qiang Liu ◽  
Qian Cai ◽  
Chang Liu ◽  
Feng-Wei Bao ◽  
Zhen-Qiu Zhang
Keyword(s):  
Oral Administration ◽  
Simultaneous Determination ◽  
Pharmacokinetic Study ◽  
Rosmarinic Acid ◽  
Rat Plasma ◽  
Hplc Method ◽  
Radix Salviae Miltiorrhizae ◽  
Salviae Miltiorrhizae ◽  
Hawthorn Extract

A simple and sensitive HPLC method was developed for simultaneous determination of danshensu (DSS), rosmarinic acid (RA), lithospermic acid (LA), salvianolic acid B (SAB), and hyperoside (HP) in rat plasma. This method validated was successfully applied to the pharmacokinetic study of the main active ingredients after oral administration ofRadix Salviae Miltiorrhizaeextract (SME), hawthorn extract (HTE), and a combination of both extracts (2.5 : 1) to rats. The results indicated that there have been great differences in pharmacokinetics between a single extract and a combination of both extracts. A combination of both extracts can enhance their bioavailabilities and delay the elimination of SAB and DSS in rats.

Development and validation of an RP-HPLC method for the quantitation of Orteronel (TAK-700), a CYP17A1 enzyme inhibitor, in rat plasma and its application to a pharmacokinetic study

2013 ◽  
Vol 27 (12) ◽  
pp. 1590-1594 ◽  
Author(s):  
Avinash Kumar ◽  
Vijay Kumar S ◽  
Sandip Gurav ◽  
Mohd Zainuddin ◽  
Purushottam Dewang ◽  
...  
Keyword(s):  
Pharmacokinetic Study ◽  
Enzyme Inhibitor ◽  
Rat Plasma ◽  
Hplc Method ◽  
Rp Hplc ◽  
Development And Validation

A simplified and sensitive validated RP-HPLC method for determination of temozolomide in rat plasma and its application to a pharmacokinetic study

2018 ◽  
Vol 41 (10) ◽  
pp. 692-697 ◽  
Author(s):  
Archana Khosa ◽  
Kowthavarapu V. Krishna ◽  
Ranendra N. Saha ◽  
Sunil K. Dubey ◽  
Satish Reddi
Keyword(s):  
Pharmacokinetic Study ◽  
Rat Plasma ◽  
Hplc Method ◽  
Rp Hplc

Determination and pharmacokinetic study of nodakenin in rat plasma by RP‐HPLC method

2008 ◽  
Vol 22 (7) ◽  
pp. 758-762 ◽  
Author(s):  
Peng Zhang ◽  
Fei Li ◽  
Xiu‐Wei Yang
Keyword(s):  
Pharmacokinetic Study ◽  
Rat Plasma ◽  
Hplc Method ◽  
Rp Hplc

Development and validation of a RP-HPLC method for the quantitation of tofacitinib in rat plasma and its application to a pharmacokinetic study

2015 ◽  
Vol 29 (9) ◽  
pp. 1325-1329 ◽  
Author(s):  
Vijay Kumar S ◽  
Vinay Dhiman ◽  
Kalpesh Kumar Giri ◽  
Kuldeep Sharma ◽  
Mohd Zainuddin ◽  
...  
Keyword(s):  
Pharmacokinetic Study ◽  
Rat Plasma ◽  
Hplc Method ◽  
Rp Hplc ◽  
Development And Validation
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