A simplified and sensitive validated RP-HPLC method for determination of temozolomide in rat plasma and its application to a pharmacokinetic study

2018 ◽  
Vol 41 (10) ◽  
pp. 692-697 ◽  
Author(s):  
Archana Khosa ◽  
Kowthavarapu V. Krishna ◽  
Ranendra N. Saha ◽  
Sunil K. Dubey ◽  
Satish Reddi
Keyword(s):  
Pharmacokinetic Study ◽  
Rat Plasma ◽  
Hplc Method ◽  
Rp Hplc

scholarly journals Simultaneous Determination and Pharmacokinetic Comparisons of Multi-Ingredients after Oral Administration ofRadix Salviae MiltiorrhizaeExtract, Hawthorn Extract, and a Combination of Both Extracts to Rats

2014 ◽  
Vol 2014 ◽  
pp. 1-9 ◽  
Author(s):  
Yu-Qiang Liu ◽  
Qian Cai ◽  
Chang Liu ◽  
Feng-Wei Bao ◽  
Zhen-Qiu Zhang
Keyword(s):  
Oral Administration ◽  
Simultaneous Determination ◽  
Pharmacokinetic Study ◽  
Rosmarinic Acid ◽  
Rat Plasma ◽  
Hplc Method ◽  
Radix Salviae Miltiorrhizae ◽  
Salviae Miltiorrhizae ◽  
Hawthorn Extract

A simple and sensitive HPLC method was developed for simultaneous determination of danshensu (DSS), rosmarinic acid (RA), lithospermic acid (LA), salvianolic acid B (SAB), and hyperoside (HP) in rat plasma. This method validated was successfully applied to the pharmacokinetic study of the main active ingredients after oral administration ofRadix Salviae Miltiorrhizaeextract (SME), hawthorn extract (HTE), and a combination of both extracts (2.5 : 1) to rats. The results indicated that there have been great differences in pharmacokinetics between a single extract and a combination of both extracts. A combination of both extracts can enhance their bioavailabilities and delay the elimination of SAB and DSS in rats.

Ecofriendly chromatographic methods for determination of co-prescribed drugs, olanzapine and metformin, in rat plasma

Bioanalysis ◽  
2020 ◽  
Vol 12 (9) ◽  
pp. 597-613
Author(s):  
Aml A Emam ◽  
Neven M Habib ◽  
Hamada M Mahmoud ◽  
Nada S Abdelwhab ◽  
Maha M Abdelrahman
Keyword(s):  
Pharmaceutical Preparation ◽  
Rat Plasma ◽  
Reversed Phase ◽  
Hplc Method ◽  
Hypoglycemic Agent ◽  
Chromatographic Methods ◽  
Rp Hplc ◽  
Development And Validation ◽  
Developing System

Background: Olanzapine (OLZ) is one of most recommended drugs for the treatment of schizophrenia while metformin (MET) is the most commonly used hypoglycemic agent. Aim: Development and validation of two green, sensitive and accurate chromatographic methods for the simultaneous determination of OLZ along with the co-prescribed, MET. Materials & methods: TLC-densitometric method with a developing system consisting of methylene chloride:methanol:ethyl acetate:triethylamine (4:4:5:0.1, by volume) and a reversed-phase (RP)-HPLC method where the chromatographic separation was performed using ethanol:water mixture (50: 50, v/v) as a mobile phase. Results: TLC-densitometric method had linearity over concentration ranges of 160–4000 ng/band for OLZ and 150–4500 ng/band for MET, while RP-HPLC method was linear and validated over concentration range of 300–20000 ng/ml for OLZ and MET. Conclusion: Pharmacokinetic study was successfully performed and suggested the possibility of co-administration of MET with OLZ and their further formulation in one pharmaceutical preparation to enhance patient’s compliance.

Development and validation of an RP-HPLC method for the quantitation of Orteronel (TAK-700), a CYP17A1 enzyme inhibitor, in rat plasma and its application to a pharmacokinetic study

2013 ◽  
Vol 27 (12) ◽  
pp. 1590-1594 ◽  
Author(s):  
Avinash Kumar ◽  
Vijay Kumar S ◽  
Sandip Gurav ◽  
Mohd Zainuddin ◽  
Purushottam Dewang ◽  
...  
Keyword(s):  
Pharmacokinetic Study ◽  
Enzyme Inhibitor ◽  
Rat Plasma ◽  
Hplc Method ◽  
Rp Hplc ◽  
Development And Validation

A rapid and simple RP-HPLC method for quantification of kirenol in rat plasma after oral administration and its application to pharmacokinetic study

2010 ◽  
Vol 25 (5) ◽  
pp. 542-546 ◽  
Author(s):  
Xiao-Li Song ◽  
Qing-Ying Zhang ◽  
Zhe-Ming Wang ◽  
Hong-Zheng Fu ◽  
Rui-Qin Qian
Keyword(s):  
Oral Administration ◽  
Pharmacokinetic Study ◽  
Rat Plasma ◽  
Hplc Method ◽  
Rp Hplc

scholarly journals Development of HPLC Method for the Determination of Buspirone in Rat Plasma Using Fluorescence Detection and Its Application to a Pharmacokinetic Study

2016 ◽  
Vol 64 (11) ◽  
pp. 1582-1588 ◽  
Author(s):  
Ki Taek Kim ◽  
Jae-Young Lee ◽  
Ju-Hwan Park ◽  
Min Hwan Kim ◽  
Ji-Su Kim ◽  
...  
Keyword(s):  
Fluorescence Detection ◽  
Pharmacokinetic Study ◽  
Rat Plasma ◽  
Hplc Method

Sensitive and precise HPLC method with back-extraction clean-up step for the determination of sildenafil in rat plasma and its application to a pharmacokinetic study

2015 ◽  
Vol 29 (10) ◽  
pp. 1559-1566 ◽  
Author(s):  
Beata Strach ◽  
Elżbieta Wyska ◽  
Krzysztof Pociecha ◽  
Anna Krupa ◽  
Renata Jachowicz
Keyword(s):  
Pharmacokinetic Study ◽  
Rat Plasma ◽  
Hplc Method ◽  
Back Extraction
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