A Validated LC‐MS/MS Method for Simultaneous Quantification of Simvastatin and Simvastatin Acid in Beagle Plasma: Application to an Absolute Bioavailability Study

2021 ◽  
Author(s):  
Yu Zhang ◽  
Jian He ◽  
Xiao Tang ◽  
Zunjian Zhang ◽  
Yuan Tian
Keyword(s):  
Absolute Bioavailability ◽  
Simultaneous Quantification ◽  
Simvastatin Acid ◽  
Bioavailability Study

scholarly journals Oral vinorelbine pharmacokinetics and absolute bioavailability study in patients with solid tumors

2001 ◽  
Vol 12 (11) ◽  
pp. 1643-1649 ◽  
Author(s):  
M. Marty ◽  
P. Fumoleau ◽  
A. Adenis ◽  
Y. Rousseau ◽  
Y. Merrouche ◽  
...  
Keyword(s):  
Solid Tumors ◽  
Absolute Bioavailability ◽  
Oral Vinorelbine ◽  
Bioavailability Study

scholarly journals Pharmacokinetic and Absolute Bioavailability Study of Total Panax Notoginsenoside, a Typical Multiple Constituent Traditional Chinese Medicine (TCM) in Rats

2007 ◽  
Vol 30 (5) ◽  
pp. 847-851 ◽  
Author(s):  
Xiaoyu Li ◽  
Guangji Wang ◽  
Jianguo Sun ◽  
Haiping Hao ◽  
Yuqing Xiong ◽  
...  
Keyword(s):  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Absolute Bioavailability ◽  
Bioavailability Study

scholarly journals ABSOLUTE AND RELATIVE BIOAVAILABILITY STUDY FOR THE NEWLY DEVELOPED NASAL NANOEMULSION IN SITU GEL OF ONDANSETRON HCl IN COMPARISON TO CONVENTIONALLY PREPARED IN SITU GEL AND INTRAVENOUS DOSAGES FORMS

2018 ◽  
Vol 10 (5) ◽  
pp. 105
Author(s):  
Nidhal K. Maraie ◽  
Yasser Q. Almajidi ◽  
Ahmed Alshadher
Keyword(s):  
Relative Bioavailability ◽  
The Body ◽  
Absolute Bioavailability ◽  
Pharmacokinetic Studies ◽  
Bioavailability Enhancement ◽  
In Situ Gel ◽  
Bioavailability Study ◽  
The Absolute

Objective: The aim of the work was to study the absolute and relative bioavailability (using rabbits) of ondansetron HCl (ONH)from our newly prepared intranasal mucoadhesive nanoemulsion in situ gel (NIG) in comparison to intranasal mucoadhesive in situ gel (IG) prepared by the conventional method and intravenous injection.Methods: Six male rabbits weighing 2.5-3 kg were used in this study, where the dose of ondansetron HCl (ONH) was calculated based on the body surface area (BSA) which is equivalent to 140μl (containing 10 mg/ml) of NIG and IG and 700μl of intravenous Zofran® injection (containing 2 mg/ml) were given to the rabbits, separated with one week washout period. Serial blood samples were withdrawn and analyzed for simultaneous determination of the drug using HPLC (Knaure; 150 ×4.6 mm; 5 μm particle size; 25 cm length) supported by guard column C18-4 mm diameter.Results: The pharmacokinetics parameters for NIG; Cmax, Tmax, AUC0-t, AUC0-∞were found to be greater than conventional in situ gel (IG). In vivo pharmacokinetic studies in rabbits showed a significant increase in Cmax and AUC 0-α(P<0.001) with shorter Tmaxusing NIG compared to IG containing the same NIG excipients, while the absolute bioavailability for NIG and IG (was 80.541 and 51.068 respectively).Conclusion: The present studies ratify the bioavailability enhancement potential of NE used to prepare NIG for the drug and significantly high absolute bioavailability to be used as a successful alternative route to the IV injection and improve patient compliance.

An improved and fully validated LC–MS/MS method for the simultaneous quantification of simvastatin and simvastatin acid in human plasma

2008 ◽  
Vol 46 (4) ◽  
pp. 771-779 ◽  
Author(s):  
Constantinos Apostolou ◽  
Constantinos Kousoulos ◽  
Yannis Dotsikas ◽  
Georgios-Stefanos Soumelas ◽  
Filomila Kolocouri ◽  
...  
Keyword(s):  
Human Plasma ◽  
Simultaneous Quantification ◽  
Simvastatin Acid

Overcoming bioanalytical challenges in an Onglyza®intravenous [14C]microdose absolute bioavailability study with accelerator MS

Bioanalysis ◽  
2012 ◽  
Vol 4 (15) ◽  
pp. 1855-1870 ◽  
Author(s):  
Xiaohui (Sophia) Xu ◽  
Stephen R Dueker ◽  
Lisa J Christopher ◽  
Pete N Lohstroh ◽  
Chi Fung (Anther) Keung ◽  
...  
Keyword(s):  
Absolute Bioavailability ◽  
Bioavailability Study

A convenient strategy to overcome interference in LC-MS/MS analysis: Application in a microdose absolute bioavailability study

2019 ◽  
Vol 165 ◽  
pp. 198-206 ◽  
Author(s):  
Long Yuan ◽  
Christine Huang ◽  
Peggy Liu-Kreyche ◽  
Kimberly Voronin ◽  
R. Marcus Fancher ◽  
...  
Keyword(s):  
Absolute Bioavailability ◽  
Ms Analysis ◽  
Bioavailability Study ◽  
Analysis Application

scholarly journals A new sensitive UPLC-MS/MS method for the determination of cucurbitacin B in rat plasma: application to an absolute bioavailability study

RSC Advances ◽  
2018 ◽  
Vol 8 (54) ◽  
pp. 30978-30985
Author(s):  
Ya Xiao ◽  
Qiang Zhao ◽  
Qian Wu ◽  
Jinhua Chang ◽  
Hefei Xue ◽  
...  
Keyword(s):  
Internal Standard ◽  
Rat Plasma ◽  
Absolute Bioavailability ◽  
Cucurbitacin B ◽  
Bioavailability Study

A method was developed for the determination of CuB in plasma using UPLC-MS/MS with estrone as an internal standard, and the pharmacokinetics and absolute bioavailability of CuB in rats were examined.

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