Predicting the expression of recombinant monoclonal antibodies in Chinese hamster ovary cells based on sequence features of the CDR3 domain

Biotechnology Progress ◽

10.1002/btpr.1839 ◽

2013 ◽

Vol 30 (1) ◽

pp. 188-197 ◽

Author(s):

Leon P. Pybus ◽

David C. James ◽

Greg Dean ◽

Tim Slidel ◽

Colin Hardman ◽

...

Keyword(s):

Monoclonal Antibodies ◽

Chinese Hamster Ovary ◽

Chinese Hamster Ovary Cells ◽

Chinese Hamster ◽

Ovary Cells ◽

Sequence Features

Download Full-text

Understanding the effect of increased cell specific productivity on galactosylation of monoclonal antibodies produced using Chinese hamster ovary cells

Journal of Biotechnology ◽

10.1016/j.jbiotec.2021.01.023 ◽

2021 ◽

Vol 329 ◽

pp. 92-103

Author(s):

Sri R. Madabhushi ◽

Alexei A. Podtelezhnikov ◽

Nicholas Murgolo ◽

Sen Xu ◽

Henry Lin

Keyword(s):

Monoclonal Antibodies ◽

Chinese Hamster Ovary ◽

Chinese Hamster Ovary Cells ◽

Chinese Hamster ◽

Specific Productivity ◽

Download Full-text

The Less the Better: How Suppressed Base Addition Boosts Production of Monoclonal Antibodies With Chinese Hamster Ovary Cells

Frontiers in Bioengineering and Biotechnology ◽

10.3389/fbioe.2019.00076 ◽

2019 ◽

Vol 7 ◽

Author(s):

Max Becker ◽

Lisa Junghans ◽

Attila Teleki ◽

Jan Bechmann ◽

Ralf Takors

Keyword(s):

Monoclonal Antibodies ◽

Chinese Hamster Ovary ◽

Chinese Hamster Ovary Cells ◽

Chinese Hamster ◽

Download Full-text

Epitope Mapping of the Nonspecific Cross-Reacting Antigen Using Various Related Recombinant Proteins Expressed in Chinese Hamster Ovary Cells and Eight Distinct Monoclonal Antibodies

Immunological Investigations ◽

10.3109/08820139209066185 ◽

1992 ◽

Vol 21 (2) ◽

pp. 143-158 ◽

Author(s):

Masahide Kuroki ◽

Masatora Haruno ◽

Masaaki Murakami ◽

Mamie Wakisaka ◽

Shinzo Oikawa ◽

...

Keyword(s):

Monoclonal Antibodies ◽

Recombinant Proteins ◽

Chinese Hamster Ovary ◽

Epitope Mapping ◽

Chinese Hamster Ovary Cells ◽

Chinese Hamster ◽

Download Full-text

PDADMAC flocculation of Chinese hamster ovary cells: Enabling a centrifuge-less harvest process for monoclonal antibodies

mAbs ◽

10.1080/19420862.2015.1007824 ◽

2015 ◽

Vol 7 (2) ◽

pp. 413-427 ◽

Author(s):

Thomas McNerney ◽

Anne Thomas ◽

Anna Senczuk ◽

Krista Petty ◽

Xiaoyang Zhao ◽

...

Keyword(s):

Monoclonal Antibodies ◽

Chinese Hamster Ovary ◽

Chinese Hamster Ovary Cells ◽

Chinese Hamster ◽

Download Full-text

Activation of recombinant αIIbβ3 expressed in Chinese hamster ovary cells exposes different binding sites for fibrinogen or von Willebrand factor: evidence using monoclonal antibodies to αIIbβ3

British Journal of Haematology ◽

10.1046/j.0007-1048.2001.03332.x ◽

2002 ◽

Vol 116 (3) ◽

pp. 636-644 ◽

Author(s):

Médina Mekrache ◽

Nelly Kieffer ◽

Dominique Baruch

Keyword(s):

Monoclonal Antibodies ◽

Von Willebrand Factor ◽

Chinese Hamster Ovary ◽

Binding Sites ◽

Chinese Hamster Ovary Cells ◽

Chinese Hamster ◽

Ovary Cells ◽

Von Willebrand ◽

Willebrand Factor

Download Full-text

Bcl-xL mediates increased production of humanized monoclonal antibodies in Chinese hamster ovary cells

Biotechnology and Bioengineering ◽

10.1002/bit.20551 ◽

2005 ◽

Vol 91 (7) ◽

pp. 779-792 ◽

Author(s):

Gisela G. Chiang ◽

William P. Sisk

Keyword(s):

Monoclonal Antibodies ◽

Chinese Hamster Ovary ◽

Chinese Hamster Ovary Cells ◽

Chinese Hamster ◽

Ovary Cells ◽

Humanized Monoclonal Antibodies

Download Full-text

Characterization of murine monoclonal antibodies that recognize defined epitopes of pertussis toxin and neutralize its toxic effect on Chinese hamster ovary cells.

Infection and Immunity ◽

10.1128/iai.59.11.4249-4251.1991 ◽

1991 ◽

Vol 59 (11) ◽

pp. 4249-4251 ◽

Author(s):

M J Walker ◽

J Wehland ◽

K N Timmis ◽

B Raupach ◽

M A Schmidt

Keyword(s):

Monoclonal Antibodies ◽

Toxic Effect ◽

Pertussis Toxin ◽

Chinese Hamster Ovary ◽

Chinese Hamster Ovary Cells ◽

Chinese Hamster ◽

Ovary Cells ◽

Murine Monoclonal Antibodies

Download Full-text

Loss of a Newly Discovered microRNA in Chinese Hamster Ovary Cells Leads to Upregulation of NGNA Sialylation on Monoclonal Antibodies

Biotechnology and Bioengineering ◽

10.1002/bit.28015 ◽

2021 ◽

Author(s):

Simon Fischer ◽

Sven Mathias ◽

Anna Stadermann ◽

Shumin Yang ◽

Valerie Schmieder ◽

...

Keyword(s):

Monoclonal Antibodies ◽

Chinese Hamster Ovary ◽

Chinese Hamster Ovary Cells ◽

Chinese Hamster ◽

Download Full-text

A rapid method for simultaneous evaluation of free light chain content and aggregate content in culture media of Chinese hamster ovary cells expressing monoclonal antibodies for cell line screening

Journal of Bioscience and Bioengineering ◽

10.1016/j.jbiosc.2015.08.002 ◽

2016 ◽

Vol 121 (4) ◽

pp. 464-470 ◽

Author(s):

Yoichi Ishii ◽

Masayoshi Tsukahara ◽

Kaori Wakamatsu

Keyword(s):

Monoclonal Antibodies ◽

Cell Line ◽

Light Chain ◽

Chinese Hamster Ovary ◽

Culture Media ◽

Chinese Hamster Ovary Cells ◽

Chinese Hamster ◽

Ovary Cells ◽

Aggregate Content ◽

Simultaneous Evaluation

Download Full-text

Epitope mapping of the carcinoembryonic antigen with various related recombinant proteins expressed in chinese hamster ovary cells and 25 distinct monoclonal antibodies

Molecular Immunology ◽

10.1016/0161-5890(92)90104-6 ◽

1992 ◽

Vol 29 (2) ◽

pp. 229-240 ◽

Author(s):

Ikeda Shoichi ◽

Kuroki Masahide ◽

Haruno Masatora ◽

Oikawa Shinzo ◽

Nakazato Hiroshi ◽

...

Keyword(s):

Monoclonal Antibodies ◽

Carcinoembryonic Antigen ◽

Recombinant Proteins ◽

Chinese Hamster Ovary ◽

Epitope Mapping ◽

Chinese Hamster Ovary Cells ◽

Chinese Hamster ◽

Download Full-text