Understanding the effect of increased cell specific productivity on galactosylation of monoclonal antibodies produced using Chinese hamster ovary cells

2021 ◽  
Vol 329 ◽  
pp. 92-103
Author(s):  
Sri R. Madabhushi ◽  
Alexei A. Podtelezhnikov ◽  
Nicholas Murgolo ◽  
Sen Xu ◽  
Henry Lin
Keyword(s):  
Monoclonal Antibodies ◽  
Chinese Hamster Ovary ◽  
Chinese Hamster Ovary Cells ◽  
Chinese Hamster ◽  
Specific Productivity ◽  
Ovary Cells

Review of the current methods of Chinese Hamster Ovary (CHO) cells cultivation for production of therapeutic protein

2020 ◽  
Vol 17 ◽  
Author(s):  
Shazid Md. Sharker ◽  
Md. Atiqur Rahman
Keyword(s):  
Chinese Hamster Ovary ◽  
Cho Cells ◽  
Mass Production ◽  
Chinese Hamster Ovary Cells ◽  
Chinese Hamster ◽  
Therapeutic Protein ◽  
Specific Productivity ◽  
Ovary Cells ◽  
Further Development ◽  
Interesting Area

Most of clinical approved protein-based drugs or under in clinical trial have a profound impact in the treatment of critical diseases. The mammalian eukaryotic cells culture approaches, particularly the CHO (Chinese Hamster Ovary) cells are mainly used in the biopharmaceutical industry for the mass-production of therapeutic protein. Recent advances in CHO cell bioprocessing to yield recombinant proteins and monoclonal antibodies have enabled the expression of quality protein. The developments of cell lines are possible to upgrade specific productivity. As a result, it holds an interesting area for academic as well as industrial researchers around the world. This review will concentrate on the recent progress of the mammalian CHO cells culture technology and the future scope of further development for the mass-production of protein therapeutics.

Predicting the expression of recombinant monoclonal antibodies in Chinese hamster ovary cells based on sequence features of the CDR3 domain

2013 ◽  
Vol 30 (1) ◽  
pp. 188-197 ◽  
Author(s):  
Leon P. Pybus ◽  
David C. James ◽  
Greg Dean ◽  
Tim Slidel ◽  
Colin Hardman ◽  
...  
Keyword(s):  
Monoclonal Antibodies ◽  
Chinese Hamster Ovary ◽  
Chinese Hamster Ovary Cells ◽  
Chinese Hamster ◽  
Ovary Cells ◽  
Sequence Features

scholarly journals PDADMAC flocculation of Chinese hamster ovary cells: Enabling a centrifuge-less harvest process for monoclonal antibodies

mAbs ◽  
2015 ◽  
Vol 7 (2) ◽  
pp. 413-427 ◽  
Author(s):  
Thomas McNerney ◽  
Anne Thomas ◽  
Anna Senczuk ◽  
Krista Petty ◽  
Xiaoyang Zhao ◽  
...  
Keyword(s):  
Monoclonal Antibodies ◽  
Chinese Hamster Ovary ◽  
Chinese Hamster Ovary Cells ◽  
Chinese Hamster ◽  
Ovary Cells
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