Effective temperature shift strategy development and scale confirmation for simultaneous optimization of protein productivity and quality in Chinese hamster ovary cells

2020 ◽  
Vol 36 (3) ◽  
Author(s):  
Kyle P. McHugh ◽  
Jianlin Xu ◽  
Kathryn L. Aron ◽  
Michael C. Borys ◽  
Zheng Jian Li
Keyword(s):  
Effective Temperature ◽  
Chinese Hamster Ovary ◽  
Chinese Hamster Ovary Cells ◽  
Chinese Hamster ◽  
Temperature Shift ◽  
Simultaneous Optimization ◽  
Strategy Development ◽  
Ovary Cells ◽  
Shift Strategy ◽  
Protein Productivity

Differential Phosphoproteomic Analysis of Recombinant Chinese Hamster Ovary Cells Following Temperature Shift

2017 ◽  
Vol 16 (7) ◽  
pp. 2339-2358 ◽  
Author(s):  
Michael Henry ◽  
Martin Power ◽  
Prashant Kaushik ◽  
Orla Coleman ◽  
Martin Clynes ◽  
...  
Keyword(s):  
Chinese Hamster Ovary ◽  
Chinese Hamster Ovary Cells ◽  
Chinese Hamster ◽  
Temperature Shift ◽  
Ovary Cells

scholarly journals Versatile microscale screening platform for improving recombinant protein productivity in Chinese hamster ovary cells

2015 ◽  
Vol 5 (1) ◽  
Author(s):  
Henning Gram Hansen ◽  
Claes Nymand Nilsson ◽  
Anne Mathilde Lund ◽  
Stefan Kol ◽  
Lise Marie Grav ◽  
...  
Keyword(s):  
Recombinant Protein ◽  
Chinese Hamster Ovary ◽  
Chinese Hamster Ovary Cells ◽  
Chinese Hamster ◽  
Ovary Cells ◽  
Recombinant Protein Productivity ◽  
Protein Productivity ◽  
Screening Platform

scholarly journals Systematic development of temperature shift strategies for Chinese hamster ovary cells based on short duration cultures and kinetic modeling

mAbs ◽  
2018 ◽  
Vol 11 (1) ◽  
pp. 191-204 ◽  
Author(s):  
Jianlin Xu ◽  
Peifeng Tang ◽  
Andrew Yongky ◽  
Barry Drew ◽  
Michael C. Borys ◽  
...  
Keyword(s):  
Short Duration ◽  
Kinetic Modeling ◽  
Chinese Hamster Ovary ◽  
Chinese Hamster Ovary Cells ◽  
Chinese Hamster ◽  
Temperature Shift ◽  
Ovary Cells ◽  
Systematic Development
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