Optical coherence tomography assessment of calcified plaque modification after rotational atherectomy

2011 ◽  
Vol 81 (3) ◽  
pp. 558-561 ◽  
Author(s):  
Guilherme F. Attizzani ◽  
Lino Patrício ◽  
Hiram G. Bezerra
2015 ◽  
Vol 11 (3) ◽  
pp. e1-e1 ◽  
Author(s):  
Terumasa Koyama ◽  
Hiroyuki Okura ◽  
Teruyoshi Kume ◽  
Kenzo Fukuhara ◽  
Yoji Neishi ◽  
...  

Author(s):  
Rayyan Hemetsberger ◽  
Tommaso Gori ◽  
Ralph Toelg ◽  
Robert Byrne ◽  
Abdelhakim Allali ◽  
...  

Background: Percutaneous intervention of calcified coronary lesions often requires lesion preparation with either balloon dilatation or atherectomy. We sought to evaluate the impact of lesion preparation strategy on stent expansion following preparation of severely calcified coronary lesions with modified (cutting/scoring) balloons (MB) versus rotational atherectomy (RA) and to evaluate the impact of calcium burden as assessed by optical coherence tomography (OCT) on acute stent performance. Methods: In the PREPARE-CALC trial (Comparison of Strategies to Prepare Severely Calcified Coronary Lesions), 200 patients with severely calcified coronary lesions were randomly assigned to receive either lesion preparation with MB or RA. In 122 patients, OCT was performed before lesion preparation and at the end of the procedure. The principal end point of this OCT sub-analysis was stent expansion as assessed by OCT. The key secondary end points included stent asymmetry and eccentricity. Results: The maximal calcific arc (257.5±96.7° versus 248.7±82.1°, P =0.59), thickness (1.34±0.29 versus 1.32±0.27 mm, P =0.76), and length of calcification (21.1±9.7 versus 24.0±10.9 mm, P =0.12) did not differ between the MB versus RA group. Lesion preparation with MB versus RA lead to comparable stent expansion (73.5±13.3% versus 73.1±12.2%, respectively, P =0.85). The use of RA did not have a significant impact on stent asymmetry or eccentricity compared with the use of MB. Length of calcified plaque appeared to be increased in patients with stent underexpansion, while thickness of calcified plaque was increased in patients with stent asymmetry. Target lesion revascularization at 9 months was 3.3% when MB was used and 1.6% when RA was performed ( P =0.62). Conclusions: In this OCT sub-analysis from the PREPARE-CALC trial, calcified plaque length was increased in patients with stent underexpansion, while its thickness was higher in patients with stent asymmetry, with no impact of the lesion preparation strategy. Registration: URL: https://www.clinicaltrials.gov ; Unique identifier: NCT02502851.


2017 ◽  
Vol 10 (24) ◽  
pp. 2584-2586 ◽  
Author(s):  
Myong Hwa Yamamoto ◽  
Akiko Maehara ◽  
Keyvan Karimi Galougahi ◽  
Gary S. Mintz ◽  
Yasir Parviz ◽  
...  

2014 ◽  
Vol 171 (2) ◽  
pp. 281-283 ◽  
Author(s):  
Yusuke Fujino ◽  
Guilherme F. Attizzani ◽  
Satoko Tahara ◽  
Kensuke Takagi ◽  
Hiram G. Bezerra ◽  
...  

2021 ◽  
Author(s):  
Cheng-fu CAO ◽  
Yu-liang MA ◽  
Qi LI ◽  
Jian LIU ◽  
Hong ZHAO ◽  
...  

Abstract Purpose Rotational atherectomy (RA) has improved percutaneous treatment of severe coronary calcified lesions, but the "no-reflow" phenomenon remains a serious complication. Platelet activation by RA may contribute to the no-reflow, we use optical coherence tomography (OCT) to test the effect of RA on white thrombosis that could confirm platelet activation indirectly. Methods We analyzed 53 consecutive patients with coronary angiographic severe calcified lesions. All the patients were examined by OCT. Twenty patients received RA and OCT imaging performed before and after RA and stent implantation. The remaining patients were as a control group and OCT imaging performed before balloon dilatation and after stent implantation. Results The patients were older and higher incidence of Diabetes mellitus in the RA group. In the control group, there was no thrombogenesis during the procedure, but in the RA group, all the target vessels had white thrombosis on OCT after RA. The average number of white thrombus per lesion after RA was 7.23 ± 4.4, and the average length of every white thrombus was 0.51 ± 0.33mm. In Pearson Correlation Analysis, Thrombotic load was related with burr size (r = 0.575, P = 0.040) and rotation number (r = 0.599, P = 0.031). Conclusions White thrombosis during RA is proved by OCT in vivo. Treating calcified lesions with RA may enhance thrombogenesis. These data suggest using a proper therapy to avoid no-reflow during RA.


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