Functional coronary angiography for coronary microvascular function: the time has come!

2021 ◽  
Vol 98 (5) ◽  
pp. 836-837
Author(s):  
Odayme Quesada ◽  
Timothy D. Henry
Keyword(s):  
Coronary Angiography ◽  
Microvascular Function ◽  
Coronary Microvascular Function

Impact of Obesity on Coronary Microvascular Function in the Zucker Rat

2006 ◽  
Vol 13 (5) ◽  
pp. 389-396 ◽  
Author(s):  
RAJAN PRAKASH ◽  
JAMES D. MINTZ ◽  
DAVID W. STEPP
Keyword(s):  
Microvascular Function ◽  
Zucker Rat ◽  
Coronary Microvascular Function

Coronary microvascular function is impaired in diabetes

2000 ◽  
Vol 9 (3) ◽  
pp. A162
Author(s):  
R.A.P. Skyrme-Jones ◽  
H.M.O. Farouque ◽  
J.L. Kealey ◽  
M.J. Zhang ◽  
I.T. Meredith
Keyword(s):  
Microvascular Function ◽  
Coronary Microvascular Function

Peripheral Arterial Function and Coronary Microvascular Function in Patients with Variant Angina

Cardiology ◽  
2014 ◽  
Vol 129 (1) ◽  
pp. 20-24 ◽  
Author(s):  
Rossella Parrinello ◽  
Alfonso Sestito ◽  
Antonino Di Franco ◽  
Giulio Russo ◽  
Angelo Villano ◽  
...  
Keyword(s):  
Microvascular Function ◽  
Variant Angina ◽  
Arterial Function ◽  
Peripheral Arterial ◽  
Coronary Microvascular Function

Methods to Assess Coronary Microvascular Function

2013 ◽  
pp. 49-72
Author(s):  
Filippo Crea ◽  
Gaetano A. Lanza ◽  
Paolo G. Camici
Keyword(s):  
Microvascular Function ◽  
Coronary Microvascular Function

Microvascular Resistance Reserve for Assessment of Coronary Microvascular Function

2021 ◽  
Vol 78 (15) ◽  
pp. 1541-1549
Author(s):  
Bernard De Bruyne ◽  
Nico H.J. Pijls ◽  
Emanuele Gallinoro ◽  
Alessandro Candreva ◽  
Stephane Fournier ◽  
...  
Keyword(s):  
Microvascular Function ◽  
Microvascular Resistance ◽  
Coronary Microvascular Function

Abstract 14283: Coronary Microvascular Function is Correlated With Peak Exercise Capacity in Patients With Unexplained Cardiac Exertion Symptoms and Non-obstructive Coronary Artery Disease

Circulation ◽  
2020 ◽  
Vol 142 (Suppl_3) ◽  
Author(s):  
Ali Ahmad ◽  
Michel Corban ◽  
Takumi Toya ◽  
Frederik H Verbrugge ◽  
Jaskanwal D Sara ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Cardiac Output ◽  
Coronary Artery ◽  
Exercise Capacity ◽  
Obstructive Coronary Artery Disease ◽  
Microvascular Function ◽  
Peak Exercise ◽  
Artery Disease ◽  
Response To Exercise ◽  
Coronary Microvascular Function

Introduction: Coronary microvascular dysfunction (CMD) is prevalent in symptomatic patients with no obstructive coronary artery disease. We postulated that exercise capacity and cardiac output augmentation in response to exercise are linked to coronary microvascular function in this patient population. Methods: Fifty-one consecutive patients with unexplained cardiac exertion symptoms, non-obstructive coronary artery disease on angiography (<50% stenosis), and normal left ventricular ejection fraction (>50%) who underwent concurrent clinically indicated coronary reactivity testing and invasive cardiopulmonary exercise testing (CPEX) were included. Microvascular function was assessed by coronary flow reserve (CFR; hyperemic/resting flow) in response to intracoronary adenosine injection. Cardiac output (CO) was calculated at rest and peak exercise using Fick’s formula. CO limitation was defined as a measured (peak CO - resting CO) <80% than the expected [6*absolute ΔVO 2 (Peak VO 2 -Rest VO 2 ) increase in CO in L/min]. The relationship between CFR, maximal exercise capacity, and CO augmentation at peak exercise was explored. Results: Patients were 56.6±10.5 years old and 73% were females. CFR had a modest positive correlation with measured increase in CO (r=0.42; P=0.003) ( Fig 1A ), and with maximal ergometric exercise capacity [in Watts/Kg] (Pearson’s r=0.33, P=0.02) ( Fig 1B ). Patients with, vs. without impaired cardiac limitations during exercise, had significantly lower CFR levels (2.6±0.5 vs 3.1±0.7; P=0.01) ( Fig 2 ). Conclusion: Impaired coronary microvascular function is associated with lower peak exercise capacity and reduced cardiac output augmentation in response to exercise, underscoring the functional ramification of CMD in symptomatic patients.

Imaging of microvascular disease

2021 ◽  
pp. 481-494
Author(s):  
Paolo G. Camici ◽  
Ornella Rimoldi
Keyword(s):  
Myocardial Ischaemia ◽  
Imaging Techniques ◽  
Microvascular Disease ◽  
Microvascular Dysfunction ◽  
Microvascular Function ◽  
Coronary Microvascular Dysfunction ◽  
Maximal Increase ◽  
Asymptomatic Subjects ◽  
Coronary Microvascular Function

Beside obstructive disease of the epicardial coronary arteries dysfunction of the coronary microvasculature has emerged in the past 20 years as an additional mechanism of myocardial ischaemia. The coronary microvasculature cannot be directly visualized in vivo, therefore, both invasive and non-invasive techniques, have been developed to assess parameters that depend directly on coronary microvascular function. Studies at the microcirculatory level entail the use of vasodilators to obtain near-maximal vasodilation. The ratio of the maximal increase of blood flow above its resting value the coronary flow reserve (CFR) allows to gain an insight into the integrated circulatory function. The diagnostic accuracy of imaging techniques can be exploited to detect impairments of myocardial perfusion in asymptomatic subjects with cardiovascular risk factors. The assessment of the coronary microvascular function has provided novel details on the pathophysiological role of coronary microvascular dysfunction in the development of myocardial ischaemia bearing also important prognostic implications.

A simple, novel catheter-based method to evaluate endothelium-dependent coronary microvascular function in a porcine model

2008 ◽  
Vol 9 (3) ◽  
pp. 211
Author(s):  
T. Shinke ◽  
J. Li ◽  
L. Pendyala ◽  
J.P. Chen ◽  
T.J. Brinton ◽  
...  
Keyword(s):  
Porcine Model ◽  
Microvascular Function ◽  
Coronary Microvascular Function
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