ChemInform Abstract: BRIDGED POLYCYCLIC COMPOUNDS PART 79, STERIC ACCELERATION IN FREE-RADICAL BROMINATION REACTIONS

From intermolecular and intramolecular competition experiments, it has been established that, by comparison with an N-methyl substituent, an N-acetyl group deactivates glycine residues in piperazine-2,5-diones towards free-radical bromination. Combined with the ease of introduction and removal of N-acetyl substituents, the deactivating effect provides a method for regiocontrolled functionalization of these compounds.

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ChemInform Abstract: Free-Radical Bromination of Selected Organic Compounds in Water.

ChemInform ◽

10.1002/chin.199723067 ◽

2010 ◽

Vol 28 (23) ◽

pp. no-no

Author(s):

H. SHAW ◽

H. D. PERLMUTTER ◽

C. GU ◽

S. D. ARCO ◽

T. O. QUIBUYEN

Keyword(s):

Free Radical ◽

Organic Compounds ◽

Radical Bromination

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Estimation of H2O2 Content in Free Radical Bromination and Oxidation Reactions by the H2O2-HBr System Generated Effluent Samples by Iodometry Method

Asian Journal of Chemistry ◽

10.14233/ajchem.2013.13739 ◽

2013 ◽

Vol 25 (7) ◽

pp. 4107-4108 ◽

Cited By ~ 1

Author(s):

K. Tirumala L. Vaikunta Rao ◽

Y.V. Mohan ◽

Naveen ◽

L. Vaikunta Rao

Keyword(s):

Free Radical ◽

Oxidation Reactions ◽

H2o2 Content ◽

Radical Bromination

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Stereoelectronic effects on chemoselectivity in the free radical bromination of arylcyclopropanes

Journal of the American Chemical Society ◽

10.1021/ja00170a021 ◽

1990 ◽

Vol 112 (14) ◽

pp. 5557-5562 ◽

Cited By ~ 11

Author(s):

James M. Tanko ◽

Rosemal H. Mas ◽

N. Kamrudin Suleman

Keyword(s):

Free Radical ◽

Stereoelectronic Effects ◽

Radical Bromination

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THE FREE RADICAL BRO MINA TION OF ETHYL PYRIDAZINES: THEORETICAL STUDIES

Southern Brazilian Journal of Chemistry - Southern Brazilian Journal of Chemistry, Volume 28, No. 28, 2020 ◽

10.48141/sbjchem.v22.n22.2014.56_revista2014.pdf ◽

2014 ◽

Vol 22 (22) ◽

pp. 53-60

Author(s):

I. A. ADEJORO ◽

R. O. Ogede ◽

C. U. Ibeji ◽

O. O. Adeboye

Keyword(s):

Free Radical ◽

Rapid Method ◽

Computational Methods ◽

Theoretical Studies ◽

Hartree Fock ◽

Radical Bromination ◽

Total Energies ◽

Pyridazine Derivatives ◽

Semi Empirical

Theoretical studies on free radical bromination by N-bromosuccinimide were carried out on a range of ethyl-3-methoxy-pyridazine derivatives. The investigations of these reactions performed, in order to develop a convenient and rapid theoretical means of predicting selectivity. The geometry optimizations of the total energies of the reactants and the products were calculated using Semi-empirical; AMI, MNDO, PM3 e Hartree Fock, HF3- 21 G computational methods. The calculation performed using PM3 Hamiltonian gave the best qualitative predictions, thus providing a rapid method for the selectivity of the reactions used in the synthesis of novel heterocyclic analogs of neurotransmitters.

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