THE FREE RADICAL BRO MINA TION OF ETHYL PYRIDAZINES: THEORETICAL STUDIES
Keyword(s):
Theoretical studies on free radical bromination by N-bromosuccinimide were carried out on a range of ethyl-3-methoxy-pyridazine derivatives. The investigations of these reactions performed, in order to develop a convenient and rapid theoretical means of predicting selectivity. The geometry optimizations of the total energies of the reactants and the products were calculated using Semi-empirical; AMI, MNDO, PM3 e Hartree Fock, HF3- 21 G computational methods. The calculation performed using PM3 Hamiltonian gave the best qualitative predictions, thus providing a rapid method for the selectivity of the reactions used in the synthesis of novel heterocyclic analogs of neurotransmitters.
1996 ◽
Vol 368
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pp. 235-243
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2003 ◽
Vol 58
(5-6)
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pp. 363-372
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2013 ◽
Vol 25
(7)
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pp. 4107-4108
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1990 ◽
Vol 112
(14)
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pp. 5557-5562
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2009 ◽
Vol 910
(1-3)
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pp. 61-68
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2014 ◽
Vol 16
(28)
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pp. 14368-14377
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